GlyCosmos Portal

Annotation

Keyword

Alternative splicing
Cytoplasm
Endocytosis
Hydrolase
Lipid metabolism
Membrane
Methylation
Phosphoprotein
RNA-binding
Reference proteome
Repeat

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q62910	Synaptic inositol 1,4,5-trisphosphate 5-phosphatase 1
A6JLD7

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 15 in total

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GO Term	Evidence Code	PMID
positive regulation of endosome organization	IEA ISO
positive regulation of gliogenesis	IMP	19282871
postsynaptic neurotransmitter receptor internalization	ISO
learning	IEA ISO
synaptic vesicle transport	ISO

GO Hierarchy

biological process

metabolic process [inference]

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process

phosphatidylinositol dephosphorylation

dephosphorylation [inference]

phospholipid dephosphorylation [inference]

phosphatidylinositol dephosphorylation

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process

phosphatidylinositol dephosphorylation

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process

phosphatidylinositol dephosphorylation

lipid modification [inference]

phospholipid dephosphorylation [inference]

phosphatidylinositol dephosphorylation

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process

phosphatidylinositol dephosphorylation

primary metabolic process [inference]

lipid metabolic process [inference]

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process

phosphatidylinositol dephosphorylation

lipid modification [inference]

phospholipid dephosphorylation [inference]

phosphatidylinositol dephosphorylation

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process

phosphatidylinositol dephosphorylation

organic substance metabolic process [inference]

lipid metabolic process [inference]

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process

phosphatidylinositol dephosphorylation

lipid modification [inference]

phospholipid dephosphorylation [inference]

phosphatidylinositol dephosphorylation

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process

phosphatidylinositol dephosphorylation

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process

phosphatidylinositol dephosphorylation

cellular process [inference]

vesicle-mediated transport [inference]

endocytosis [inference]

receptor-mediated endocytosis [inference]

receptor internalization [inference]

neurotransmitter receptor internalization [inference]

postsynaptic neurotransmitter receptor internalization

presynaptic endocytosis [inference]

synaptic vesicle endocytosis

postsynaptic endocytosis [inference]

postsynaptic neurotransmitter receptor internalization

vesicle-mediated transport in synapse [inference]

presynaptic endocytosis [inference]

synaptic vesicle endocytosis

postsynaptic endocytosis [inference]

postsynaptic neurotransmitter receptor internalization

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process

phosphatidylinositol dephosphorylation

dephosphorylation [inference]

phospholipid dephosphorylation [inference]

phosphatidylinositol dephosphorylation

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process

phosphatidylinositol dephosphorylation

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process

phosphatidylinositol dephosphorylation

lipid modification [inference]

phospholipid dephosphorylation [inference]

phosphatidylinositol dephosphorylation

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process

phosphatidylinositol dephosphorylation

synaptic vesicle transport

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component disassembly [inference]

protein-containing complex disassembly [inference]

protein depolymerization [inference]

vesicle uncoating [inference]

clathrin coat disassembly [inference]

synaptic vesicle uncoating

cellular component assembly [inference]

protein-containing complex assembly [inference]

synaptic vesicle priming

protein-containing complex organization [inference]

protein-containing complex disassembly [inference]

protein depolymerization [inference]

vesicle uncoating [inference]

clathrin coat disassembly [inference]

synaptic vesicle uncoating

protein-containing complex assembly [inference]

synaptic vesicle priming

exocytic process [inference]

synaptic vesicle priming

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

cognition [inference]

learning or memory [inference]

learning

behavior [inference]

learning or memory [inference]

learning

response to stimulus [inference]

response to chemical [inference]

response to organic substance [inference]

response to lipid [inference]

response to retinoic acid

response to cytokine

response to oxygen-containing compound [inference]

response to retinoic acid

localization [inference]

protein-containing complex localization [inference]

neurotransmitter receptor internalization [inference]

postsynaptic neurotransmitter receptor internalization

establishment of localization [inference]

transport [inference]

neurotransmitter transport

vesicle-mediated transport [inference]

endocytosis [inference]

receptor-mediated endocytosis [inference]

receptor internalization [inference]

neurotransmitter receptor internalization [inference]

postsynaptic neurotransmitter receptor internalization

presynaptic endocytosis [inference]

synaptic vesicle endocytosis

postsynaptic endocytosis [inference]

postsynaptic neurotransmitter receptor internalization

vesicle-mediated transport in synapse [inference]

presynaptic endocytosis [inference]

synaptic vesicle endocytosis

postsynaptic endocytosis [inference]

postsynaptic neurotransmitter receptor internalization

synaptic vesicle transport

import into cell [inference]

endocytosis [inference]

receptor-mediated endocytosis [inference]

receptor internalization [inference]

neurotransmitter receptor internalization [inference]

postsynaptic neurotransmitter receptor internalization

presynaptic endocytosis [inference]

synaptic vesicle endocytosis

postsynaptic endocytosis [inference]

postsynaptic neurotransmitter receptor internalization

establishment of localization in cell [inference]

establishment of vesicle localization [inference]

synaptic vesicle transport

presynaptic endocytosis [inference]

synaptic vesicle endocytosis

postsynaptic endocytosis [inference]

postsynaptic neurotransmitter receptor internalization

establishment of organelle localization [inference]

establishment of vesicle localization [inference]

synaptic vesicle transport

organelle localization [inference]

vesicle localization [inference]

establishment of vesicle localization [inference]

synaptic vesicle transport

synaptic vesicle localization [inference]

synaptic vesicle transport

establishment of organelle localization [inference]

establishment of vesicle localization [inference]

synaptic vesicle transport

biological regulation [inference]

regulation of biological process [inference]

regulation of localization [inference]

regulation of transport [inference]

positive regulation of transport [inference]

positive regulation of endocytosis [inference]

positive regulation of receptor-mediated endocytosis

regulation of vesicle-mediated transport [inference]

regulation of endocytosis [inference]

positive regulation of endocytosis [inference]

positive regulation of receptor-mediated endocytosis

regulation of receptor-mediated endocytosis [inference]

regulation of receptor internalization [inference]

regulation of postsynaptic neurotransmitter receptor internalization

positive regulation of receptor-mediated endocytosis

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis [inference]

positive regulation of gliogenesis

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of endosome organization

positive regulation of endocytosis [inference]

positive regulation of receptor-mediated endocytosis

positive regulation of transport [inference]

positive regulation of endocytosis [inference]

positive regulation of receptor-mediated endocytosis

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis [inference]

positive regulation of gliogenesis

positive regulation of nervous system development [inference]

positive regulation of neurogenesis [inference]

positive regulation of gliogenesis

positive regulation of multicellular organismal process [inference]

positive regulation of nervous system development [inference]

positive regulation of neurogenesis [inference]

positive regulation of gliogenesis

regulation of developmental process [inference]

regulation of cell differentiation [inference]

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis [inference]

positive regulation of gliogenesis

regulation of cell development [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis [inference]

positive regulation of gliogenesis

regulation of neurogenesis [inference]

regulation of gliogenesis [inference]

positive regulation of gliogenesis

positive regulation of neurogenesis [inference]

positive regulation of gliogenesis

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis [inference]

positive regulation of gliogenesis

positive regulation of nervous system development [inference]

positive regulation of neurogenesis [inference]

positive regulation of gliogenesis

regulation of multicellular organismal development [inference]

regulation of nervous system development [inference]

regulation of neurogenesis [inference]

regulation of gliogenesis [inference]

positive regulation of gliogenesis

positive regulation of neurogenesis [inference]

positive regulation of gliogenesis

positive regulation of nervous system development [inference]

positive regulation of neurogenesis [inference]

positive regulation of gliogenesis

regulation of cellular process [inference]

regulation of cell differentiation [inference]

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis [inference]

positive regulation of gliogenesis

regulation of cell development [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis [inference]

positive regulation of gliogenesis

regulation of neurogenesis [inference]

regulation of gliogenesis [inference]

positive regulation of gliogenesis

positive regulation of neurogenesis [inference]

positive regulation of gliogenesis

positive regulation of cellular process [inference]

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis [inference]

positive regulation of gliogenesis

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of endosome organization

positive regulation of endocytosis [inference]

positive regulation of receptor-mediated endocytosis

regulation of cellular component organization [inference]

regulation of endocytosis [inference]

positive regulation of endocytosis [inference]

positive regulation of receptor-mediated endocytosis

regulation of receptor-mediated endocytosis [inference]

regulation of receptor internalization [inference]

regulation of postsynaptic neurotransmitter receptor internalization

positive regulation of receptor-mediated endocytosis

regulation of organelle organization [inference]

positive regulation of organelle organization [inference]

positive regulation of endosome organization

regulation of endosome organization [inference]

positive regulation of endosome organization

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of endosome organization

positive regulation of endocytosis [inference]

positive regulation of receptor-mediated endocytosis

regulation of vesicle-mediated transport [inference]

regulation of endocytosis [inference]

positive regulation of endocytosis [inference]

positive regulation of receptor-mediated endocytosis

regulation of receptor-mediated endocytosis [inference]

regulation of receptor internalization [inference]

regulation of postsynaptic neurotransmitter receptor internalization

positive regulation of receptor-mediated endocytosis

regulation of multicellular organismal process [inference]

positive regulation of multicellular organismal process [inference]

positive regulation of nervous system development [inference]

positive regulation of neurogenesis [inference]

positive regulation of gliogenesis

regulation of multicellular organismal development [inference]

regulation of nervous system development [inference]

regulation of neurogenesis [inference]

regulation of gliogenesis [inference]

positive regulation of gliogenesis

positive regulation of neurogenesis [inference]

positive regulation of gliogenesis

positive regulation of nervous system development [inference]

positive regulation of neurogenesis [inference]

positive regulation of gliogenesis

regulation of biological quality [inference]

regulation of postsynaptic membrane neurotransmitter receptor levels [inference]

postsynaptic neurotransmitter receptor internalization

regulation of postsynaptic neurotransmitter receptor internalization

Displaying entries **11 - 15** of 15 in total

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GO Term	Evidence Code	PMID
membrane coat	ISO
synaptic membrane	IDA	9079704 9428629
perinuclear region of cytoplasm	IBA ISS
cytoplasm	IBA
glutamatergic synapse	ISO

GO Hierarchy

cellular component

protein-containing complex

membrane protein complex [inference]

membrane coat

clathrin coat [inference]

clathrin coat of coated pit

plasma membrane protein complex [inference]

clathrin coat of coated pit

cellular anatomical entity [inference]

cytoplasm

membrane

organelle membrane [inference]

vesicle membrane

plasma membrane region [inference]

synaptic membrane

cell junction [inference]

synapse [inference]

excitatory synapse [inference]

parallel fiber to Purkinje cell synapse

perinuclear region of cytoplasm

presynapse

terminal bouton

postsynapse

supramolecular complex [inference]

supramolecular polymer [inference]

supramolecular fiber [inference]

polymeric cytoskeletal fiber [inference]

microtubule

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
phosphatidylinositol phosphate phosphatase activity	IEA
protein binding	IPI	10764144 11518713 17257598 20427313 9238017 9341169 9950691
EH domain binding	IDA	9428629
SH3 domain binding	IDA IPI	11498538 17097615 8552192
protein-containing complex binding	IDA	17257598

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

phosphoric ester hydrolase activity [inference]

phosphatase activity [inference]

inositol phosphate phosphatase activity

inositol trisphosphate phosphatase activity [inference]

inositol-1,4,5-trisphosphate 5-phosphatase activity

phosphatidylinositol phosphate phosphatase activity

phosphatidylinositol bisphosphate phosphatase activity [inference]

phosphatidylinositol-4,5-bisphosphate phosphatase activity [inference]

phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity

phosphatidylinositol phosphate 5-phosphatase activity

phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity

phosphatidylinositol phosphate 4-phosphatase activity [inference]

phosphatidylinositol-4-phosphate phosphatase activity

phosphatidylinositol monophosphate phosphatase activity [inference]

binding [inference]

protein binding

protein domain specific binding [inference]

protein-containing complex binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

RNA binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

synaptojanin-1

Functional Category

J: Translation, ribosomal structure and biogenesis
K: Transcription
X: Mobilome: prophages, transposons

Displaying **all 3** entries
Gene Ontology
SH3 domain binding
lipid metabolic process
phosphatidylinositol phosphate phosphatase activity

Displaying **all 9** entries
InterPro
Endonuclease/exonuclease/phosphatase superfamily
Inositol 5-phosphatase
Inositol polyphosphate-related phosphatase
Nucleotide-binding alpha-beta plait domain superfamily
RNA recognition motif domain
RNA-binding domain superfamily
SAC domain
Synaptojanin-1, RNA recognition motif
Synaptojanin-1/2, RNA recognition motif

Alliance of Genome Resources

Expression

Displaying **all 2** entries
Location	References
protein-containing complex	PMID:17257598
synaptic membrane	PMID:9079704

Rhea

RHEA:22764

H₂O + a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate)

phosphate + a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate)

Enzyme

3.1.3.36

PMID

Disease

Disease Ontology

Displaying **all 5** entries
DO ID	Disease Name	Source
DOID:0060894	early-onset Parkinson's disease	Alliance of Genome Resources
DOID:0060898	Parkinson's disease 20	Alliance of Genome Resources
DOID:0080464	developmental and epileptic encephalopathy 53	Alliance of Genome Resources
DOID:14250	Down syndrome	Alliance of Genome Resources
DOID:14330	Parkinson's disease	Alliance of Genome Resources

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP012821
Gene Name: synaptojanin 1

Ortholog

Displaying entries **1 - 10** of **112** in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	8867		HGNC:11503	HUMAN58315
Drosophila melanogaster	37517		FB:FBgn0034691
Mus musculus	104015	10090_1:004ae7	MGI:1354961	MOUSE17591
Caenorhabditis elegans	178284		WB:WBGene00006763
Danio rerio	337236		ZFIN:ZDB-GENE-030131-9180	DANRE00491
Pan troglodytes	473959			PANTR25563
Canis lupus familiaris	478403			CANLF12816
Macaca mulatta	707829			MACMU30812
Saccharomyces cerevisiae S288C	854276		SGD:S000005635
Saccharomyces cerevisiae S288C	854815		SGD:S000001264

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Summary

External Links

Annotation

OrthoDB (Group)

LIPID MAPS Gene / Proteome Database

International Collaboration

Acknowledgements