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folate hydrolase 1

Summary

Gene Symbol

Folh1

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

85309

PubChem

85309

Alliance of Genome Resources

RGD:70963

Annotation

Keyword

Alternative splicing
Calcium
Carboxypeptidase
Cell membrane
Dipeptidase
Glycoprotein
Metal-binding
Metalloprotease
Multifunctional enzyme
Phosphoprotein
Reference proteome
Signal-anchor
Transmembrane helix
Zinc

Proteins

Displaying 1 entry
UniProt	Protein Name
P70627	Folate hydrolase 1 Folylpoly-gamma-glutamate carboxypeptidase Glutamate carboxypeptidase II Membrane glutamate carboxypeptidase N-acetylated-alpha-linked acidic dipeptidase I Prostate-specific membrane antigen homolog Pteroylpoly-gamma-glutamate carboxypeptidase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
proteolysis	IEA ISO
folic acid-containing compound metabolic process	IEA ISO
protein catabolic process	IDA	9501243
C-terminal protein deglutamylation	ISO
positive regulation of apoptotic process	IMP	12876198

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

cellular modified amino acid metabolic process [inference]

folic acid-containing compound metabolic process

protein metabolic process [inference]

protein modification process [inference]

peptidyl-amino acid modification [inference]

peptidyl-glutamic acid modification [inference]

protein deglutamylation [inference]

C-terminal protein deglutamylation

post-translational protein modification [inference]

C-terminal protein amino acid modification [inference]

C-terminal protein deglutamylation

pteridine-containing compound metabolic process [inference]

folic acid-containing compound metabolic process

organonitrogen compound catabolic process [inference]

protein catabolic process

catabolic process [inference]

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process

organonitrogen compound catabolic process [inference]

protein catabolic process

cellular metabolic process [inference]

cellular modified amino acid metabolic process [inference]

folic acid-containing compound metabolic process

cellular aromatic compound metabolic process [inference]

pteridine-containing compound metabolic process [inference]

folic acid-containing compound metabolic process

heterocycle metabolic process [inference]

pteridine-containing compound metabolic process [inference]

folic acid-containing compound metabolic process

primary metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

peptidyl-amino acid modification [inference]

peptidyl-glutamic acid modification [inference]

protein deglutamylation [inference]

C-terminal protein deglutamylation

post-translational protein modification [inference]

C-terminal protein amino acid modification [inference]

C-terminal protein deglutamylation

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process

protein metabolic process [inference]

protein modification process [inference]

peptidyl-amino acid modification [inference]

peptidyl-glutamic acid modification [inference]

protein deglutamylation [inference]

C-terminal protein deglutamylation

post-translational protein modification [inference]

C-terminal protein amino acid modification [inference]

C-terminal protein deglutamylation

macromolecule modification [inference]

protein modification process [inference]

peptidyl-amino acid modification [inference]

peptidyl-glutamic acid modification [inference]

protein deglutamylation [inference]

C-terminal protein deglutamylation

post-translational protein modification [inference]

C-terminal protein amino acid modification [inference]

C-terminal protein deglutamylation

organic cyclic compound metabolic process [inference]

pteridine-containing compound metabolic process [inference]

folic acid-containing compound metabolic process

organonitrogen compound metabolic process [inference]

cellular modified amino acid metabolic process [inference]

folic acid-containing compound metabolic process

protein metabolic process [inference]

protein modification process [inference]

peptidyl-amino acid modification [inference]

peptidyl-glutamic acid modification [inference]

protein deglutamylation [inference]

C-terminal protein deglutamylation

post-translational protein modification [inference]

C-terminal protein amino acid modification [inference]

C-terminal protein deglutamylation

pteridine-containing compound metabolic process [inference]

folic acid-containing compound metabolic process

organonitrogen compound catabolic process [inference]

protein catabolic process

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process

organonitrogen compound catabolic process [inference]

protein catabolic process

cellular process [inference]

cellular metabolic process [inference]

cellular modified amino acid metabolic process [inference]

folic acid-containing compound metabolic process

cellular aromatic compound metabolic process [inference]

pteridine-containing compound metabolic process [inference]

folic acid-containing compound metabolic process

heterocycle metabolic process [inference]

pteridine-containing compound metabolic process [inference]

folic acid-containing compound metabolic process

biological regulation [inference]

regulation of biological process [inference]

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

regulation of cellular process [inference]

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

positive regulation of apoptotic process

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

positive regulation of cellular process [inference]

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

Displaying **all 3** entries
GO Term	Evidence Code	PMID
membrane	ISO
plasma membrane	IBA IEA ISO
cell surface	ISO

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cell surface

membrane

plasma membrane

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
tetrahydrofolyl-poly(glutamate) polymer binding	ISO
metal ion binding	IEA
dipeptidase activity	IEA ISO
metallopeptidase activity	IEA
metallocarboxypeptidase activity	ISO

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity

metallopeptidase activity

metalloexopeptidase activity [inference]

metallocarboxypeptidase activity

exopeptidase activity [inference]

carboxypeptidase activity

metallocarboxypeptidase activity

metalloexopeptidase activity [inference]

metallocarboxypeptidase activity

dipeptidase activity

catalytic activity, acting on a protein [inference]

peptidase activity

metallopeptidase activity

metalloexopeptidase activity [inference]

metallocarboxypeptidase activity

exopeptidase activity [inference]

carboxypeptidase activity

metallocarboxypeptidase activity

metalloexopeptidase activity [inference]

metallocarboxypeptidase activity

dipeptidase activity

binding [inference]

amide binding [inference]

peptide binding [inference]

oligopeptide binding [inference]

Ac-Asp-Glu binding

ion binding [inference]

anion binding [inference]

Ac-Asp-Glu binding

cation binding [inference]

metal ion binding

tetrahydrofolyl-poly(glutamate) polymer binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

N-acetylated-alpha-linked acidic dipeptidase 2

Functional Category

G: Carbohydrate transport and metabolism
K: Transcription
M: Cell wall/membrane/envelope biogenesis
O: Posttranslational modification, protein turnover, chaperones

Displaying 1 entry
Gene Ontology
carboxypeptidase activity

Displaying **all 6** entries
InterPro
PA domain superfamily
PA domain
Peptidase M28
Transferrin receptor protein 1/Glutamate carboxypeptidase 2-like
Transferrin receptor-like, dimerisation domain superfamily
Transferrin receptor-like, dimerisation domain

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:3526	cerebral infarction	Alliance of Genome Resources
DOID:7693	abdominal aortic aneurysm	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of **155** in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	2346		HGNC:3788	HUMAN05895
Mus musculus	53320	10090_1:002305	MGI:1858193	MOUSE52167
Mus musculus	72560	10090_1:002dba
Caenorhabditis elegans	180386		WB:WBGene00020082
Homo sapiens	219595		HGNC:13636
Danio rerio	393247		ZFIN:ZDB-GENE-040426-1025	DANRE09605
Sus scrofa	397677			PIGXX35163
Pan troglodytes	451185			PANTR04036
Pan troglodytes	451475			PANTR04036
Canis lupus familiaris	476775			CANLF08190

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements