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carbohydrate sulfotransferase 1

Summary

Gene Symbol

CHST1

Aliases

C6ST
KSGal6ST
Keratan sulfotransferase

Organism

Homo sapiens (human)

External Links

NCBI Gene

8534

GGDB ID

gg027

HGNC

1969

mRNA

NM_003654

map

11p11.2-p11.1

Protein

NP_003645

OMIM

603797

KEGG Gene ID

hsa:8534

PubChem

8534

Alliance of Genome Resources

HGNC:1969

Annotation

Keyword

Carbohydrate metabolism
Glycoprotein
Golgi apparatus
Inflammatory response
Reference proteome
Signal-anchor
Transferase
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
O43916	Galactose/N-acetylglucosamine/N-acetylglucosamine 6-O-sulfotransferase 1 Keratan sulfate Gal-6 sulfotransferase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
sulfur compound metabolic process	IDA	10330415
keratan sulfate metabolic process	IBA IDA	9405439
galactose metabolic process	IDA	10330415
keratan sulfate biosynthetic process	IDA TAS	17690104
inflammatory response	IEA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

aminoglycan metabolic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

keratan sulfate biosynthetic process

glycosaminoglycan metabolic process [inference]

glycosaminoglycan biosynthetic process [inference]

keratan sulfate biosynthetic process

mucopolysaccharide metabolic process [inference]

keratan sulfate metabolic process

keratan sulfate biosynthetic process

organonitrogen compound biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

keratan sulfate biosynthetic process

biosynthetic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

keratan sulfate biosynthetic process

sulfur compound biosynthetic process [inference]

keratan sulfate biosynthetic process

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

keratan sulfate biosynthetic process

carbohydrate derivative biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

keratan sulfate biosynthetic process

organonitrogen compound biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

keratan sulfate biosynthetic process

cellular metabolic process [inference]

sulfur compound metabolic process

keratan sulfate metabolic process

keratan sulfate biosynthetic process

sulfur compound biosynthetic process [inference]

keratan sulfate biosynthetic process

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

keratan sulfate biosynthetic process

sulfur compound biosynthetic process [inference]

keratan sulfate biosynthetic process

primary metabolic process [inference]

carbohydrate metabolic process [inference]

polysaccharide metabolic process

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

galactose metabolic process

small molecule metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

galactose metabolic process

organic substance metabolic process [inference]

carbohydrate metabolic process [inference]

polysaccharide metabolic process

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

galactose metabolic process

macromolecule metabolic process [inference]

polysaccharide metabolic process

aminoglycan metabolic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

keratan sulfate biosynthetic process

glycosaminoglycan metabolic process [inference]

glycosaminoglycan biosynthetic process [inference]

keratan sulfate biosynthetic process

mucopolysaccharide metabolic process [inference]

keratan sulfate metabolic process

keratan sulfate biosynthetic process

macromolecule biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

keratan sulfate biosynthetic process

carbohydrate derivative metabolic process [inference]

aminoglycan metabolic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

keratan sulfate biosynthetic process

glycosaminoglycan metabolic process [inference]

glycosaminoglycan biosynthetic process [inference]

keratan sulfate biosynthetic process

mucopolysaccharide metabolic process [inference]

keratan sulfate metabolic process

keratan sulfate biosynthetic process

amino sugar metabolic process [inference]

glucosamine-containing compound metabolic process [inference]

N-acetylglucosamine metabolic process

carbohydrate derivative biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

keratan sulfate biosynthetic process

organonitrogen compound metabolic process [inference]

aminoglycan metabolic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

keratan sulfate biosynthetic process

glycosaminoglycan metabolic process [inference]

glycosaminoglycan biosynthetic process [inference]

keratan sulfate biosynthetic process

mucopolysaccharide metabolic process [inference]

keratan sulfate metabolic process

keratan sulfate biosynthetic process

organonitrogen compound biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

keratan sulfate biosynthetic process

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

keratan sulfate biosynthetic process

carbohydrate derivative biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

keratan sulfate biosynthetic process

organonitrogen compound biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

keratan sulfate biosynthetic process

cellular process [inference]

cellular metabolic process [inference]

sulfur compound metabolic process

keratan sulfate metabolic process

keratan sulfate biosynthetic process

sulfur compound biosynthetic process [inference]

keratan sulfate biosynthetic process

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

keratan sulfate biosynthetic process

sulfur compound biosynthetic process [inference]

keratan sulfate biosynthetic process

response to stimulus [inference]

response to stress [inference]

defense response [inference]

inflammatory response

Displaying **all 3** entries
GO Term	Evidence Code	PMID
trans-Golgi network	IBA
membrane	NAS	9405439
Golgi membrane	TAS

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

organelle membrane [inference]

bounding membrane of organelle [inference]

Golgi membrane

organelle subcompartment [inference]

Golgi apparatus subcompartment [inference]

trans-Golgi network

Displaying **all 4** entries
GO Term	Evidence Code	PMID
keratan sulfotransferase activity	IBA IDA TAS	17690104 9405439
sulfotransferase activity	IDA	10330415
protein binding	IPI	32296183
N-acetylglucosamine 6-O-sulfotransferase activity	IBA

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring sulphur-containing groups [inference]

sulfotransferase activity

binding [inference]

protein binding

Gene Ontology information from NCBI Gene and UniProt.

GlycoGene Database (GGDB)

GGDB ID

gg027

Gene Symbol

CHST1

Reactions

Displaying 1 entry
Donor	Acceptor	Product	Reference
PAPS	G00065MO		10642612

Displaying **all 3** entries
Donor	Acceptor	Reference
PAPS	G31119YY	10642612
PAPS	G00058MO	10642612
PAPS	G00065MO	10642612

Displaying **all 2** entries
Donor	Acceptor	Product	Reference
PAPS	G00054MO		10642612
PAPS	G00055MO		10642612

Orthologous Gene

Displaying **all 2** entries
Species	Protein	mRNA
Rattus norvegicus	XP_230293	XM_230293
Mus musculus	NP_076339	NM_023850

KEGG BRITE Database

Orthology

K01022

Name

keratan sulfate 6-sulfotransferase 1 [EC:2.8.2.21]

References

9405439

Disease

Disease Ontology

Displaying **all 4** entries
DO ID	Disease Name	Source
DOID:12721	multiple epiphyseal dysplasia	DisGeNET
DOID:12804	mucopolysaccharidosis IV	DisGeNET
DOID:2256	osteochondrodysplasia	DisGeNET
DOID:83	cataract	DisGeNET

Ortholog

Displaying entries **1 - 10** of 92 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Drosophila melanogaster	33913	FB:FBgn0031826
Drosophila melanogaster	33914	FB:FBgn0051637
Latimeria chalumnae	102366374		LATCH19716
Danio rerio	445124	ZFIN:ZDB-GENE-040801-21	DANRE46659
Astyanax mexicanus	103023582		ASTMX22555
Astyanax mexicanus	103042358		ASTMX21470
Ictalurus punctatus	108264188		ICTPU27832
Ictalurus punctatus	108269117		ICTPU34351
Electrophorus electricus	113570891		ELEEL01808
Electrophorus electricus	113581797		ELEEL28372

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UniCarb-DR

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Other Information

Tools

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Summary

External Links

Annotation

GlycoGene Database (GGDB)

KEGG BRITE Database

International Collaboration

Acknowledgements