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serine/threonine protein kinase PRK1

Summary

Gene Symbol

PRK1

Organism

Saccharomyces cerevisiae S288C

External Links

NCBI Gene

854713

PubChem

854713

Alliance of Genome Resources

SGD:S000001357

Annotation

Keyword

ATP-binding
Cytoskeleton
Phosphoprotein
Reference proteome
Serine/threonine-protein kinase

Proteins

Displaying 1 entry
UniProt	Protein Name
P40494	p53-regulating kinase 1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
negative regulation of actin cortical patch assembly	IGI	9885245
protein phosphorylation	IEA
negative regulation of clathrin-dependent endocytosis	IGI IMP	12956961 13679512
phosphorylation	IEA
chromatin remodeling	IEA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phosphorylation

protein phosphorylation

primary metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation

macromolecule modification [inference]

protein modification process [inference]

protein phosphorylation

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation

cellular process [inference]

actin filament-based process [inference]

actin cytoskeleton organization [inference]

cortical actin cytoskeleton organization [inference]

actin cortical patch assembly

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phosphorylation

protein phosphorylation

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

cytoskeleton organization [inference]

actin cytoskeleton organization [inference]

cortical actin cytoskeleton organization [inference]

actin cortical patch assembly

cortical cytoskeleton organization [inference]

cortical actin cytoskeleton organization [inference]

actin cortical patch assembly

cellular component assembly [inference]

actin cortical patch assembly

protein-containing complex organization [inference]

protein-DNA complex organization [inference]

chromatin organization [inference]

chromatin remodeling

actin cortical patch organization [inference]

actin cortical patch assembly

supramolecular fiber organization [inference]

actin filament organization

biological regulation [inference]

regulation of biological process [inference]

regulation of localization [inference]

regulation of transport [inference]

negative regulation of transport [inference]

negative regulation of endocytosis [inference]

negative regulation of receptor-mediated endocytosis [inference]

negative regulation of clathrin-dependent endocytosis

regulation of vesicle-mediated transport [inference]

regulation of endocytosis [inference]

negative regulation of endocytosis [inference]

negative regulation of receptor-mediated endocytosis [inference]

negative regulation of clathrin-dependent endocytosis

regulation of receptor-mediated endocytosis [inference]

negative regulation of receptor-mediated endocytosis [inference]

negative regulation of clathrin-dependent endocytosis

regulation of clathrin-dependent endocytosis [inference]

negative regulation of clathrin-dependent endocytosis

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of cellular component organization [inference]

negative regulation of organelle organization [inference]

negative regulation of cytoskeleton organization [inference]

negative regulation of actin cortical patch assembly

negative regulation of protein-containing complex assembly

negative regulation of endocytosis [inference]

negative regulation of receptor-mediated endocytosis [inference]

negative regulation of clathrin-dependent endocytosis

negative regulation of transport [inference]

negative regulation of endocytosis [inference]

negative regulation of receptor-mediated endocytosis [inference]

negative regulation of clathrin-dependent endocytosis

regulation of cellular process [inference]

regulation of actin filament-based process [inference]

regulation of actin cytoskeleton organization [inference]

negative regulation of actin cortical patch assembly

regulation of cellular component biogenesis [inference]

regulation of protein-containing complex assembly [inference]

negative regulation of protein-containing complex assembly

negative regulation of actin cortical patch assembly

negative regulation of cellular process [inference]

negative regulation of cellular component organization [inference]

negative regulation of organelle organization [inference]

negative regulation of cytoskeleton organization [inference]

negative regulation of actin cortical patch assembly

negative regulation of protein-containing complex assembly

negative regulation of endocytosis [inference]

negative regulation of receptor-mediated endocytosis [inference]

negative regulation of clathrin-dependent endocytosis

regulation of cellular component organization [inference]

regulation of endocytosis [inference]

negative regulation of endocytosis [inference]

negative regulation of receptor-mediated endocytosis [inference]

negative regulation of clathrin-dependent endocytosis

regulation of receptor-mediated endocytosis [inference]

negative regulation of receptor-mediated endocytosis [inference]

negative regulation of clathrin-dependent endocytosis

regulation of clathrin-dependent endocytosis [inference]

negative regulation of clathrin-dependent endocytosis

regulation of organelle organization [inference]

negative regulation of organelle organization [inference]

negative regulation of cytoskeleton organization [inference]

negative regulation of actin cortical patch assembly

regulation of cytoskeleton organization [inference]

regulation of actin cytoskeleton organization [inference]

negative regulation of actin cortical patch assembly

negative regulation of cytoskeleton organization [inference]

negative regulation of actin cortical patch assembly

regulation of protein-containing complex assembly [inference]

negative regulation of protein-containing complex assembly

negative regulation of cellular component organization [inference]

negative regulation of organelle organization [inference]

negative regulation of cytoskeleton organization [inference]

negative regulation of actin cortical patch assembly

negative regulation of protein-containing complex assembly

negative regulation of endocytosis [inference]

negative regulation of receptor-mediated endocytosis [inference]

negative regulation of clathrin-dependent endocytosis

regulation of vesicle-mediated transport [inference]

regulation of endocytosis [inference]

negative regulation of endocytosis [inference]

negative regulation of receptor-mediated endocytosis [inference]

negative regulation of clathrin-dependent endocytosis

regulation of receptor-mediated endocytosis [inference]

negative regulation of receptor-mediated endocytosis [inference]

negative regulation of clathrin-dependent endocytosis

regulation of clathrin-dependent endocytosis [inference]

negative regulation of clathrin-dependent endocytosis

Displaying **all 4** entries
GO Term	Evidence Code	PMID
mating projection tip	HDA	19053807
actin cortical patch	IDA IEA	10087264 9885245
cytoskeleton	IEA
cytoplasm	IBA IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytoplasm

site of polarized growth [inference]

mating projection tip

organelle [inference]

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

cytoskeleton

intracellular organelle [inference]

intracellular non-membrane-bounded organelle [inference]

cytoskeleton

cell pole [inference]

cell tip [inference]

mating projection tip

endocytic patch [inference]

actin cortical patch

Displaying **all 5** entries
GO Term	Evidence Code	PMID
protein serine kinase activity	IEA
protein serine/threonine kinase activity	IBA IDA IEA	11739778 12956961 13679512 17978096 9885245
ATP binding	IEA
protein kinase activity	HDA IEA	16319894
histone H2AS1 kinase activity	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring phosphorus-containing groups [inference]

kinase activity [inference]

protein kinase activity

protein serine/threonine kinase activity

histone H2AS1 kinase activity

histone kinase activity [inference]

histone H2A kinase activity [inference]

histone H2AS1 kinase activity

protein serine kinase activity

phosphotransferase activity, alcohol group as acceptor [inference]

protein kinase activity

protein serine/threonine kinase activity

histone H2AS1 kinase activity

histone kinase activity [inference]

histone H2A kinase activity [inference]

histone H2AS1 kinase activity

protein serine kinase activity

catalytic activity, acting on a protein [inference]

protein kinase activity

protein serine/threonine kinase activity

histone H2AS1 kinase activity

histone kinase activity [inference]

histone H2A kinase activity [inference]

histone H2AS1 kinase activity

protein serine kinase activity

histone modifying activity [inference]

histone kinase activity [inference]

histone H2A kinase activity [inference]

histone H2AS1 kinase activity

binding [inference]

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

kinase

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 5** entries
Gene Ontology
AP-2 adaptor complex binding
ATP binding
actin cortical patch assembly
actin filament organization
regulation of clathrin-dependent endocytosis

Displaying **all 3** entries
InterPro
Protein kinase domain
Protein kinase-like domain superfamily
Serine/threonine-protein kinase, active site

Alliance of Genome Resources

Expression

Displaying **all 2** entries
Location	References
mating projection tip	PMID:19053807
actin cortical patch	PMID:10087264 PMID:9885245

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:14330	Parkinson's disease	Alliance of Genome Resources

Ortholog

Displaying entries **41 - 45** of 45 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources
Saccharomyces kudriavzevii IFO 1802	80924681	226230_0:000a7a
Saccharomyces kudriavzevii IFO 1802	80926780	226230_0:001191
Xenopus tropicalis	100135375		Xenbase:XB-GENE-986555
Xenopus tropicalis	100486326		Xenbase:XB-GENE-492403
Danio rerio	100534954		ZFIN:ZDB-GENE-091118-25