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lysophospholipase

Summary

Gene Symbol

NTE1

Organism

Saccharomyces cerevisiae S288C

External Links

NCBI Gene

854943

PubChem

854943

Alliance of Genome Resources

SGD:S000004524

Annotation

Keyword

Endoplasmic reticulum
Hydrolase
Lipid degradation
Lipid droplet
Phosphoprotein
Reference proteome
Repeat
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q04958	Intracellular phospholipase B Neuropathy target esterase homolog

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
glycerolipid metabolic process	IEA
phosphatidylcholine metabolic process	IEA
phosphatidylcholine catabolic process	IMP	15044461
regulation of phospholipid biosynthetic process	IMP	19841481
lipid catabolic process	IEA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

phosphatidylcholine metabolic process

phosphatidylcholine catabolic process

organonitrogen compound catabolic process [inference]

phosphatidylcholine catabolic process

catabolic process [inference]

cellular catabolic process [inference]

cellular lipid catabolic process [inference]

phospholipid catabolic process [inference]

glycerophospholipid catabolic process [inference]

phosphatidylcholine catabolic process

glycerolipid catabolic process [inference]

glycerophospholipid catabolic process [inference]

phosphatidylcholine catabolic process

organic substance catabolic process [inference]

lipid catabolic process

cellular lipid catabolic process [inference]

phospholipid catabolic process [inference]

glycerophospholipid catabolic process [inference]

phosphatidylcholine catabolic process

glycerolipid catabolic process [inference]

glycerophospholipid catabolic process [inference]

phosphatidylcholine catabolic process

organophosphate catabolic process [inference]

phospholipid catabolic process [inference]

glycerophospholipid catabolic process [inference]

phosphatidylcholine catabolic process

organonitrogen compound catabolic process [inference]

phosphatidylcholine catabolic process

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylcholine metabolic process

phosphatidylcholine catabolic process

glycerophospholipid catabolic process [inference]

phosphatidylcholine catabolic process

phospholipid catabolic process [inference]

glycerophospholipid catabolic process [inference]

phosphatidylcholine catabolic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylcholine metabolic process

phosphatidylcholine catabolic process

glycerophospholipid catabolic process [inference]

phosphatidylcholine catabolic process

phospholipid catabolic process [inference]

glycerophospholipid catabolic process [inference]

phosphatidylcholine catabolic process

organophosphate catabolic process [inference]

phospholipid catabolic process [inference]

glycerophospholipid catabolic process [inference]

phosphatidylcholine catabolic process

cellular catabolic process [inference]

cellular lipid catabolic process [inference]

phospholipid catabolic process [inference]

glycerophospholipid catabolic process [inference]

phosphatidylcholine catabolic process

glycerolipid catabolic process [inference]

glycerophospholipid catabolic process [inference]

phosphatidylcholine catabolic process

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylcholine metabolic process

phosphatidylcholine catabolic process

glycerophospholipid catabolic process [inference]

phosphatidylcholine catabolic process

phospholipid catabolic process [inference]

glycerophospholipid catabolic process [inference]

phosphatidylcholine catabolic process

cellular lipid catabolic process [inference]

phospholipid catabolic process [inference]

glycerophospholipid catabolic process [inference]

phosphatidylcholine catabolic process

glycerolipid catabolic process [inference]

glycerophospholipid catabolic process [inference]

phosphatidylcholine catabolic process

glycerolipid metabolic process

glycerophospholipid metabolic process [inference]

phosphatidylcholine metabolic process

phosphatidylcholine catabolic process

glycerophospholipid catabolic process [inference]

phosphatidylcholine catabolic process

glycerolipid catabolic process [inference]

glycerophospholipid catabolic process [inference]

phosphatidylcholine catabolic process

primary metabolic process [inference]

lipid metabolic process [inference]

lipid catabolic process

cellular lipid catabolic process [inference]

phospholipid catabolic process [inference]

glycerophospholipid catabolic process [inference]

phosphatidylcholine catabolic process

glycerolipid catabolic process [inference]

glycerophospholipid catabolic process [inference]

phosphatidylcholine catabolic process

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylcholine metabolic process

phosphatidylcholine catabolic process

glycerophospholipid catabolic process [inference]

phosphatidylcholine catabolic process

phospholipid catabolic process [inference]

glycerophospholipid catabolic process [inference]

phosphatidylcholine catabolic process

cellular lipid catabolic process [inference]

phospholipid catabolic process [inference]

glycerophospholipid catabolic process [inference]

phosphatidylcholine catabolic process

glycerolipid catabolic process [inference]

glycerophospholipid catabolic process [inference]

phosphatidylcholine catabolic process

glycerolipid metabolic process

glycerophospholipid metabolic process [inference]

phosphatidylcholine metabolic process

phosphatidylcholine catabolic process

glycerophospholipid catabolic process [inference]

phosphatidylcholine catabolic process

glycerolipid catabolic process [inference]

glycerophospholipid catabolic process [inference]

phosphatidylcholine catabolic process

organic substance metabolic process [inference]

lipid metabolic process [inference]

lipid catabolic process

cellular lipid catabolic process [inference]

phospholipid catabolic process [inference]

glycerophospholipid catabolic process [inference]

phosphatidylcholine catabolic process

glycerolipid catabolic process [inference]

glycerophospholipid catabolic process [inference]

phosphatidylcholine catabolic process

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylcholine metabolic process

phosphatidylcholine catabolic process

glycerophospholipid catabolic process [inference]

phosphatidylcholine catabolic process

phospholipid catabolic process [inference]

glycerophospholipid catabolic process [inference]

phosphatidylcholine catabolic process

cellular lipid catabolic process [inference]

phospholipid catabolic process [inference]

glycerophospholipid catabolic process [inference]

phosphatidylcholine catabolic process

glycerolipid catabolic process [inference]

glycerophospholipid catabolic process [inference]

phosphatidylcholine catabolic process

glycerolipid metabolic process

glycerophospholipid metabolic process [inference]

phosphatidylcholine metabolic process

phosphatidylcholine catabolic process

glycerophospholipid catabolic process [inference]

phosphatidylcholine catabolic process

glycerolipid catabolic process [inference]

glycerophospholipid catabolic process [inference]

phosphatidylcholine catabolic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylcholine metabolic process

phosphatidylcholine catabolic process

glycerophospholipid catabolic process [inference]

phosphatidylcholine catabolic process

phospholipid catabolic process [inference]

glycerophospholipid catabolic process [inference]

phosphatidylcholine catabolic process

organophosphate catabolic process [inference]

phospholipid catabolic process [inference]

glycerophospholipid catabolic process [inference]

phosphatidylcholine catabolic process

organonitrogen compound metabolic process [inference]

phosphatidylcholine metabolic process

phosphatidylcholine catabolic process

organonitrogen compound catabolic process [inference]

phosphatidylcholine catabolic process

organic substance catabolic process [inference]

lipid catabolic process

cellular lipid catabolic process [inference]

phospholipid catabolic process [inference]

glycerophospholipid catabolic process [inference]

phosphatidylcholine catabolic process

glycerolipid catabolic process [inference]

glycerophospholipid catabolic process [inference]

phosphatidylcholine catabolic process

organophosphate catabolic process [inference]

phospholipid catabolic process [inference]

glycerophospholipid catabolic process [inference]

phosphatidylcholine catabolic process

organonitrogen compound catabolic process [inference]

phosphatidylcholine catabolic process

cellular process [inference]

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylcholine metabolic process

phosphatidylcholine catabolic process

glycerophospholipid catabolic process [inference]

phosphatidylcholine catabolic process

phospholipid catabolic process [inference]

glycerophospholipid catabolic process [inference]

phosphatidylcholine catabolic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylcholine metabolic process

phosphatidylcholine catabolic process

glycerophospholipid catabolic process [inference]

phosphatidylcholine catabolic process

phospholipid catabolic process [inference]

glycerophospholipid catabolic process [inference]

phosphatidylcholine catabolic process

organophosphate catabolic process [inference]

phospholipid catabolic process [inference]

glycerophospholipid catabolic process [inference]

phosphatidylcholine catabolic process

cellular catabolic process [inference]

cellular lipid catabolic process [inference]

phospholipid catabolic process [inference]

glycerophospholipid catabolic process [inference]

phosphatidylcholine catabolic process

glycerolipid catabolic process [inference]

glycerophospholipid catabolic process [inference]

phosphatidylcholine catabolic process

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylcholine metabolic process

phosphatidylcholine catabolic process

glycerophospholipid catabolic process [inference]

phosphatidylcholine catabolic process

phospholipid catabolic process [inference]

glycerophospholipid catabolic process [inference]

phosphatidylcholine catabolic process

cellular lipid catabolic process [inference]

phospholipid catabolic process [inference]

glycerophospholipid catabolic process [inference]

phosphatidylcholine catabolic process

glycerolipid catabolic process [inference]

glycerophospholipid catabolic process [inference]

phosphatidylcholine catabolic process

glycerolipid metabolic process

glycerophospholipid metabolic process [inference]

phosphatidylcholine metabolic process

phosphatidylcholine catabolic process

glycerophospholipid catabolic process [inference]

phosphatidylcholine catabolic process

glycerolipid catabolic process [inference]

glycerophospholipid catabolic process [inference]

phosphatidylcholine catabolic process

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

regulation of lipid biosynthetic process [inference]

regulation of phospholipid biosynthetic process

regulation of cellular metabolic process [inference]

regulation of phosphorus metabolic process [inference]

regulation of phosphate metabolic process [inference]

regulation of phospholipid metabolic process [inference]

regulation of phospholipid biosynthetic process

regulation of primary metabolic process [inference]

regulation of lipid metabolic process [inference]

regulation of lipid biosynthetic process [inference]

regulation of phospholipid biosynthetic process

regulation of phospholipid metabolic process [inference]

regulation of phospholipid biosynthetic process

regulation of cellular process [inference]

regulation of cellular metabolic process [inference]

regulation of phosphorus metabolic process [inference]

regulation of phosphate metabolic process [inference]

regulation of phospholipid metabolic process [inference]

regulation of phospholipid biosynthetic process

Displaying **all 4** entries
GO Term	Evidence Code	PMID
membrane	IEA
endoplasmic reticulum membrane	IEA
endoplasmic reticulum	HDA IBA IDA IEA	14562095 15044461 26928762
lipid droplet	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

organelle membrane [inference]

endoplasmic reticulum membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

lipid droplet

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular non-membrane-bounded organelle [inference]

lipid droplet

Displaying **all 2** entries
GO Term	Evidence Code	PMID
hydrolase activity	IEA
lysophospholipase activity	IBA IDA IEA	15044461

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity

hydrolase activity, acting on ester bonds [inference]

lipase activity [inference]

phospholipase activity [inference]

lysophospholipase activity

carboxylic ester hydrolase activity [inference]

lysophospholipase activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Patatin-like phospholipase domain-containing protein

Functional Category

E: Amino acid transport and metabolism
G: Carbohydrate transport and metabolism
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
hydrolase activity
lipid metabolic process
phosphatidylcholine metabolic process

Displaying **all 5** entries
InterPro
Acyl transferase/acyl hydrolase/lysophospholipase
Cyclic nucleotide-binding domain superfamily
Cyclic nucleotide-binding domain
Patatin-like phospholipase domain
RmlC-like jelly roll fold

Alliance of Genome Resources

Expression

Displaying 1 entry
Location	References
endoplasmic reticulum	PMID:14562095 PMID:15044461 PMID:26928762

Rhea

RHEA:15177

H₂O + a 1-acyl-sn-glycero-3-phosphocholine

H⁺ + sn-glycerol 3-phosphocholine + a fatty acid

Enzyme

3.1.1.5

PMID

Disease

Disease Ontology

Displaying **all 8** entries
DO ID	Disease Name	Source
DOID:0050753	cerebellar ataxia	Alliance of Genome Resources
DOID:0110790	hereditary spastic paraplegia 39	Alliance of Genome Resources
DOID:0111265	Boucher-Neuhauser syndrome	Alliance of Genome Resources
DOID:0111271	Oliver-McFarlane syndrome	Alliance of Genome Resources
DOID:1289	neurodegenerative disease	Alliance of Genome Resources
DOID:1432	blindness	Alliance of Genome Resources
DOID:1930	Laurence-Moon syndrome	Alliance of Genome Resources
DOID:2476	hereditary spastic paraplegia	Alliance of Genome Resources

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP007217
Gene Name: Nte1p

Ortholog

Displaying entries **1 - 10** of 33 in total

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Species	Gene ID	Alliance of Genome Resources
Homo sapiens	10908	HGNC:16268
Drosophila melanogaster	31716	FB:FBgn0003656
Mus musculus	50767	MGI:1354723
Danio rerio	84040	ZFIN:ZDB-GENE-010507-2
Caenorhabditis elegans	176225	WB:WBGene00022718
Caenorhabditis elegans	187474	WB:WBGene00010915
Mus musculus	241274	MGI:2385325
Rattus norvegicus	246246	RGD:708466
Rattus norvegicus	360753	RGD:1564611
Homo sapiens	375775	HGNC:24768

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Summary

External Links

Annotation

OrthoDB (Group)

LIPID MAPS Gene / Proteome Database

International Collaboration

Acknowledgements