GlyCosmos Portal

Annotation

Keyword

3D-structure
Helicase
Nucleus
Phosphoprotein
RNA-binding
Reference proteome
Ribosome biogenesis
rRNA processing

Proteins

Displaying 1 entry
UniProt	Protein Name
Q03532	Helicase associated with SET1 protein 1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 8 in total

1

2

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GO Term	Evidence Code	PMID
ribosomal small subunit biogenesis	IMP	15049817 23788678
RNA processing	IEA
snoRNA release from pre-rRNA	IMP	16908538
maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	IMP	15049817
ribosomal large subunit biogenesis	IMP	15049817 23788678

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing

ncRNA processing [inference]

rRNA processing

maturation of LSU-rRNA [inference]

maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

maturation of SSU-rRNA [inference]

maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

snoRNA release from pre-rRNA

ncRNA metabolic process [inference]

rRNA metabolic process [inference]

rRNA processing

maturation of LSU-rRNA [inference]

maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

maturation of SSU-rRNA [inference]

maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

snoRNA release from pre-rRNA

sno(s)RNA metabolic process [inference]

snoRNA release from pre-rRNA

ncRNA processing [inference]

rRNA processing

maturation of LSU-rRNA [inference]

maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

maturation of SSU-rRNA [inference]

maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

snoRNA release from pre-rRNA

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing

ncRNA processing [inference]

rRNA processing

maturation of LSU-rRNA [inference]

maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

maturation of SSU-rRNA [inference]

maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

snoRNA release from pre-rRNA

ncRNA metabolic process [inference]

rRNA metabolic process [inference]

rRNA processing

maturation of LSU-rRNA [inference]

maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

maturation of SSU-rRNA [inference]

maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

snoRNA release from pre-rRNA

sno(s)RNA metabolic process [inference]

snoRNA release from pre-rRNA

ncRNA processing [inference]

rRNA processing

maturation of LSU-rRNA [inference]

maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

maturation of SSU-rRNA [inference]

maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

snoRNA release from pre-rRNA

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing

ncRNA processing [inference]

rRNA processing

maturation of LSU-rRNA [inference]

maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

maturation of SSU-rRNA [inference]

maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

snoRNA release from pre-rRNA

ncRNA metabolic process [inference]

rRNA metabolic process [inference]

rRNA processing

maturation of LSU-rRNA [inference]

maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

maturation of SSU-rRNA [inference]

maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

snoRNA release from pre-rRNA

sno(s)RNA metabolic process [inference]

snoRNA release from pre-rRNA

ncRNA processing [inference]

rRNA processing

maturation of LSU-rRNA [inference]

maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

maturation of SSU-rRNA [inference]

maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

snoRNA release from pre-rRNA

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing

ncRNA processing [inference]

rRNA processing

maturation of LSU-rRNA [inference]

maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

maturation of SSU-rRNA [inference]

maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

snoRNA release from pre-rRNA

ncRNA metabolic process [inference]

rRNA metabolic process [inference]

rRNA processing

maturation of LSU-rRNA [inference]

maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

maturation of SSU-rRNA [inference]

maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

snoRNA release from pre-rRNA

sno(s)RNA metabolic process [inference]

snoRNA release from pre-rRNA

ncRNA processing [inference]

rRNA processing

maturation of LSU-rRNA [inference]

maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

maturation of SSU-rRNA [inference]

maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

snoRNA release from pre-rRNA

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing

ncRNA processing [inference]

rRNA processing

maturation of LSU-rRNA [inference]

maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

maturation of SSU-rRNA [inference]

maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

snoRNA release from pre-rRNA

ncRNA metabolic process [inference]

rRNA metabolic process [inference]

rRNA processing

maturation of LSU-rRNA [inference]

maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

maturation of SSU-rRNA [inference]

maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

snoRNA release from pre-rRNA

sno(s)RNA metabolic process [inference]

snoRNA release from pre-rRNA

ncRNA processing [inference]

rRNA processing

maturation of LSU-rRNA [inference]

maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

maturation of SSU-rRNA [inference]

maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

snoRNA release from pre-rRNA

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing

ncRNA processing [inference]

rRNA processing

maturation of LSU-rRNA [inference]

maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

maturation of SSU-rRNA [inference]

maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

snoRNA release from pre-rRNA

ncRNA metabolic process [inference]

rRNA metabolic process [inference]

rRNA processing

maturation of LSU-rRNA [inference]

maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

maturation of SSU-rRNA [inference]

maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

snoRNA release from pre-rRNA

sno(s)RNA metabolic process [inference]

snoRNA release from pre-rRNA

ncRNA processing [inference]

rRNA processing

maturation of LSU-rRNA [inference]

maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

maturation of SSU-rRNA [inference]

maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

snoRNA release from pre-rRNA

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing

ncRNA processing [inference]

rRNA processing

maturation of LSU-rRNA [inference]

maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

maturation of SSU-rRNA [inference]

maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

snoRNA release from pre-rRNA

ncRNA metabolic process [inference]

rRNA metabolic process [inference]

rRNA processing

maturation of LSU-rRNA [inference]

maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

maturation of SSU-rRNA [inference]

maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

snoRNA release from pre-rRNA

sno(s)RNA metabolic process [inference]

snoRNA release from pre-rRNA

ncRNA processing [inference]

rRNA processing

maturation of LSU-rRNA [inference]

maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

maturation of SSU-rRNA [inference]

maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

snoRNA release from pre-rRNA

cellular process [inference]

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing

ncRNA processing [inference]

rRNA processing

maturation of LSU-rRNA [inference]

maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

maturation of SSU-rRNA [inference]

maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

snoRNA release from pre-rRNA

ncRNA metabolic process [inference]

rRNA metabolic process [inference]

rRNA processing

maturation of LSU-rRNA [inference]

maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

maturation of SSU-rRNA [inference]

maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

snoRNA release from pre-rRNA

sno(s)RNA metabolic process [inference]

snoRNA release from pre-rRNA

ncRNA processing [inference]

rRNA processing

maturation of LSU-rRNA [inference]

maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

maturation of SSU-rRNA [inference]

maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

snoRNA release from pre-rRNA

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing

ncRNA processing [inference]

rRNA processing

maturation of LSU-rRNA [inference]

maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

maturation of SSU-rRNA [inference]

maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

snoRNA release from pre-rRNA

ncRNA metabolic process [inference]

rRNA metabolic process [inference]

rRNA processing

maturation of LSU-rRNA [inference]

maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

maturation of SSU-rRNA [inference]

maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

snoRNA release from pre-rRNA

sno(s)RNA metabolic process [inference]

snoRNA release from pre-rRNA

ncRNA processing [inference]

rRNA processing

maturation of LSU-rRNA [inference]

maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

maturation of SSU-rRNA [inference]

maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

snoRNA release from pre-rRNA

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing

ncRNA processing [inference]

rRNA processing

maturation of LSU-rRNA [inference]

maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

maturation of SSU-rRNA [inference]

maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

snoRNA release from pre-rRNA

ncRNA metabolic process [inference]

rRNA metabolic process [inference]

rRNA processing

maturation of LSU-rRNA [inference]

maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

maturation of SSU-rRNA [inference]

maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

snoRNA release from pre-rRNA

sno(s)RNA metabolic process [inference]

snoRNA release from pre-rRNA

ncRNA processing [inference]

rRNA processing

maturation of LSU-rRNA [inference]

maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

maturation of SSU-rRNA [inference]

maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

snoRNA release from pre-rRNA

cellular component organization or biogenesis [inference]

cellular component biogenesis [inference]

ribonucleoprotein complex biogenesis [inference]

Displaying **all 5** entries
GO Term	Evidence Code	PMID
preribosome, large subunit precursor	HDA IDA	11583614 17443350
90S preribosome	HDA	12150911
nuclear envelope	IDA	10684247
nucleus	IEA
nucleolus	IBA IDA IEA	10684247 15049817

GO Hierarchy

cellular component

protein-containing complex [inference]

ribonucleoprotein complex [inference]

preribosome [inference]

cellular anatomical entity [inference]

envelope [inference]

organelle envelope [inference]

nuclear envelope

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

nucleolus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular non-membrane-bounded organelle [inference]

nucleolus

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
nucleic acid binding	IEA
ATP-dependent activity, acting on RNA	IDA	15718299
hydrolase activity	IEA
helicase activity	IEA
ATP hydrolysis activity	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity

hydrolase activity, acting on acid anhydrides [inference]

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [inference]

pyrophosphatase activity [inference]

ribonucleoside triphosphate phosphatase activity [inference]

ATP hydrolysis activity

catalytic activity, acting on a nucleic acid [inference]

helicase activity

RNA helicase activity

catalytic activity, acting on RNA [inference]

RNA helicase activity

binding [inference]

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

organic cyclic compound binding [inference]

nucleic acid binding

RNA binding

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ATP-dependent activity [inference]

helicase activity

RNA helicase activity

ATP-dependent activity, acting on RNA

RNA helicase activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

ATP-dependent RNA helicase HAS

Functional Category

K: Transcription
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
ATP binding
hydrolase activity
nucleotide binding

Displaying **all 7** entries
InterPro
ATP-dependent RNA helicase DEAD-box, conserved site
DEAD/DEAH box helicase domain
Domain of unknown function DUF4217
Helicase superfamily 1/2, ATP-binding domain
Helicase, C-terminal domain-like
P-loop containing nucleoside triphosphate hydrolase
RNA helicase, DEAD-box type, Q motif

KEGG BRITE Database

Orthology

K13179

Name

ATP-dependent RNA helicase DDX18/HAS1 [EC:3.6.4.13]

References

Alliance of Genome Resources

Expression

Displaying **all 4** entries
Location	References
nuclear envelope	PMID:10684247
nucleolus	PMID:10684247 PMID:15049817
90S preribosome	PMID:12150911
preribosome, large subunit precursor	PMID:11583614 PMID:17443350

Rhea

RHEA:13065

H₂O + ATP

H⁺ + phosphate + ADP

Enzyme

PMID

Ortholog

Displaying entries **1 - 10** of 29 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources
Homo sapiens	8886		HGNC:2741
Drosophila melanogaster	42595		FB:FBgn0266581
Mus musculus	66942		MGI:1914192
Caenorhabditis elegans	172954		WB:WBGene00015232
Rattus norvegicus	308490		RGD:1549712
Danio rerio	321127		ZFIN:ZDB-GENE-030131-9685
Xenopus tropicalis	549530		Xenbase:XB-GENE-6085268
Kluyveromyces lactis	2896371	28985_0:0000e6
Eremothecium gossypii ATCC 10895	4623302	284811_0:00106b
Vanderwaltozyma polyspora DSM 70294	5544652	436907_0:000893

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

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Summary

External Links

Annotation

OrthoDB (Group)

KEGG BRITE Database

International Collaboration

Acknowledgements