GlyCosmos Portal

Displaying **all 4** entries
GO Term	Evidence Code	PMID
isocitrate dehydrogenase complex (NAD+)	IDA	16884682
mitochondrial matrix	IDA	8626605
mitochondrion	HDA IBA IEA	16823961 24769239
mitochondrial nucleoid	IDA	15692048

GO Hierarchy

cellular component

protein-containing complex [inference]

catalytic complex [inference]

tricarboxylic acid cycle enzyme complex [inference]

isocitrate dehydrogenase complex (NAD+)

oxidoreductase complex [inference]

isocitrate dehydrogenase complex (NAD+)

cellular anatomical entity [inference]

nucleoid [inference]

mitochondrial nucleoid

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

mitochondrial matrix

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

mitochondrial nucleoid

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

intracellular non-membrane-bounded organelle [inference]

mitochondrial nucleoid

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
oxidoreductase activity	IEA
magnesium ion binding	IEA
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	IEA
isocitrate dehydrogenase (NAD+) activity	IEA
NAD binding	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity

oxidoreductase activity, acting on CH-OH group of donors [inference]

oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

isocitrate dehydrogenase [NAD(P)+] activity [inference]

isocitrate dehydrogenase (NAD+) activity

binding [inference]

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

NAD binding

ion binding [inference]

cation binding [inference]

metal ion binding

magnesium ion binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

RNA binding

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

NAD binding

Gene Ontology information from NCBI Gene and UniProt.

KEGG BRITE Database

Orthology

K00030

Name

isocitrate dehydrogenase (NAD+) [EC:1.1.1.41]

References

10601238

Alliance of Genome Resources

Expression

Displaying **all 4** entries
Location	References
mitochondrion	PMID:16823961 PMID:24769239
mitochondrial matrix	PMID:8626605
isocitrate dehydrogenase complex (NAD+)	PMID:16884682
mitochondrial nucleoid	PMID:15692048

Rhea

RHEA:23632

D-threo-isocitrate + NAD⁺

CO₂ + 2-oxoglutarate + NADH

Enzyme

PMID

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0050709	early infantile epileptic encephalopathy	Alliance of Genome Resources
DOID:0110409	retinitis pigmentosa 46	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 17 in total

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Species	Gene ID	Alliance of Genome Resources
Caenorhabditis elegans	172430	WB:WBGene00016266
Caenorhabditis elegans	175598	WB:WBGene00009440
Caenorhabditis elegans	181528	WB:WBGene00007993
Drosophila melanogaster	42586	FB:FBgn0038922
Drosophila melanogaster	43102	FB:FBgn0039358
Danio rerio	415247	ZFIN:ZDB-GENE-040625-174
Danio rerio	550579	ZFIN:ZDB-GENE-050417-435
Xenopus tropicalis	594985	Xenbase:XB-GENE-492840
Xenopus tropicalis	100144949	Xenbase:XB-GENE-5825105
Homo sapiens	3420	HGNC:5385

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

All Resources

Other Information

Tools

Search Tools

Summary

External Links

Annotation

KEGG BRITE Database

International Collaboration

Acknowledgements