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ribonuclease T2

Summary

Gene Symbol

RNY1

Organism

Saccharomyces cerevisiae S288C

External Links

NCBI Gene

855980

PubChem

855980

Alliance of Genome Resources

SGD:S000006044

Annotation

Keyword

Cytoplasm
Disulfide bond
Endonuclease
Glycoprotein
Lyase
Reference proteome
Signal
Vacuole

Proteins

Displaying 1 entry
UniProt	Protein Name
Q02933

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 4** entries
GO Term	Evidence Code	PMID
cell morphogenesis	IMP	11158587
mRNA catabolic process	IMP	33875662
apoptotic process	IGI	19332891
RNA catabolic process	IBA IMP	19332891

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound catabolic process [inference]

RNA catabolic process

mRNA catabolic process

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA catabolic process

mRNA catabolic process

mRNA metabolic process [inference]

mRNA catabolic process

cellular nitrogen compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

RNA catabolic process

mRNA catabolic process

catabolic process [inference]

cellular catabolic process [inference]

aromatic compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

RNA catabolic process

mRNA catabolic process

cellular nitrogen compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

RNA catabolic process

mRNA catabolic process

heterocycle catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

RNA catabolic process

mRNA catabolic process

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

RNA catabolic process

mRNA catabolic process

organic cyclic compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

RNA catabolic process

mRNA catabolic process

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound catabolic process [inference]

RNA catabolic process

mRNA catabolic process

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA catabolic process

mRNA catabolic process

mRNA metabolic process [inference]

mRNA catabolic process

aromatic compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

RNA catabolic process

mRNA catabolic process

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound catabolic process [inference]

RNA catabolic process

mRNA catabolic process

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA catabolic process

mRNA catabolic process

mRNA metabolic process [inference]

mRNA catabolic process

cellular nitrogen compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

RNA catabolic process

mRNA catabolic process

cellular catabolic process [inference]

aromatic compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

RNA catabolic process

mRNA catabolic process

cellular nitrogen compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

RNA catabolic process

mRNA catabolic process

heterocycle catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

RNA catabolic process

mRNA catabolic process

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound catabolic process [inference]

RNA catabolic process

mRNA catabolic process

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA catabolic process

mRNA catabolic process

mRNA metabolic process [inference]

mRNA catabolic process

heterocycle catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

RNA catabolic process

mRNA catabolic process

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound catabolic process [inference]

RNA catabolic process

mRNA catabolic process

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA catabolic process

mRNA catabolic process

mRNA metabolic process [inference]

mRNA catabolic process

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

macromolecule catabolic process [inference]

RNA catabolic process

mRNA catabolic process

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA catabolic process

mRNA catabolic process

mRNA metabolic process [inference]

mRNA catabolic process

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound catabolic process [inference]

RNA catabolic process

mRNA catabolic process

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA catabolic process

mRNA catabolic process

mRNA metabolic process [inference]

mRNA catabolic process

organic cyclic compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

RNA catabolic process

mRNA catabolic process

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

RNA catabolic process

mRNA catabolic process

organic cyclic compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

RNA catabolic process

mRNA catabolic process

cellular process [inference]

cell death [inference]

programmed cell death [inference]

apoptotic process

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound catabolic process [inference]

RNA catabolic process

mRNA catabolic process

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA catabolic process

mRNA catabolic process

mRNA metabolic process [inference]

mRNA catabolic process

aromatic compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

RNA catabolic process

mRNA catabolic process

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound catabolic process [inference]

RNA catabolic process

mRNA catabolic process

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA catabolic process

mRNA catabolic process

mRNA metabolic process [inference]

mRNA catabolic process

cellular nitrogen compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

RNA catabolic process

mRNA catabolic process

cellular catabolic process [inference]

aromatic compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

RNA catabolic process

mRNA catabolic process

cellular nitrogen compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

RNA catabolic process

mRNA catabolic process

heterocycle catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

RNA catabolic process

mRNA catabolic process

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound catabolic process [inference]

RNA catabolic process

mRNA catabolic process

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA catabolic process

mRNA catabolic process

mRNA metabolic process [inference]

mRNA catabolic process

heterocycle catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

RNA catabolic process

mRNA catabolic process

developmental process [inference]

anatomical structure morphogenesis [inference]

cell morphogenesis

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

mRNA catabolic process

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

negative regulation of gene expression [inference]

mRNA catabolic process

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

mRNA catabolic process

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

mRNA catabolic process

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

mRNA catabolic process

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

mRNA catabolic process

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

mRNA catabolic process

regulation of cellular metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

mRNA catabolic process

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

negative regulation of gene expression [inference]

mRNA catabolic process

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

mRNA catabolic process

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

mRNA catabolic process

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

negative regulation of gene expression [inference]

mRNA catabolic process

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

mRNA catabolic process

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

mRNA catabolic process

negative regulation of biological process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

mRNA catabolic process

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

mRNA catabolic process

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

mRNA catabolic process

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

mRNA catabolic process

regulation of cellular process [inference]

regulation of cellular metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

mRNA catabolic process

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

negative regulation of gene expression [inference]

mRNA catabolic process

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

mRNA catabolic process

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

mRNA catabolic process

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

mRNA catabolic process

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
fungal-type vacuole	IDA	24102742
extracellular region	IBA IDA	11158587
vacuolar lumen	IEA
vacuole	IDA IEA	19332891
cytosol	HDA IDA	19332891 26928762

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

vacuolar lumen

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

storage vacuole [inference]

fungal-type vacuole

lytic vacuole [inference]

fungal-type vacuole

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

storage vacuole [inference]

fungal-type vacuole

lytic vacuole [inference]

fungal-type vacuole

Displaying **all 5** entries
GO Term	Evidence Code	PMID
lyase activity	IEA
endonuclease activity	IEA
ribonuclease T2 activity	IEA
RNA binding	IEA
RNA endonuclease activity	IBA IDA IMP	11158587 19332891

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

nuclease activity [inference]

endonuclease activity

RNA endonuclease activity

ribonuclease T2 activity

RNA nuclease activity [inference]

RNA endonuclease activity

ribonuclease T2 activity

phosphorus-oxygen lyase activity [inference]

ribonuclease T2 activity

catalytic activity, acting on a nucleic acid [inference]

catalytic activity, acting on RNA [inference]

RNA nuclease activity [inference]

RNA endonuclease activity

ribonuclease T2 activity

binding [inference]

organic cyclic compound binding [inference]

nucleic acid binding [inference]

RNA binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Ribonuclease

Functional Category

J: Translation, ribosomal structure and biogenesis
K: Transcription
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
RNA catabolic process
RNA endonuclease activity
ribonuclease T2 activity

Displaying **all 5** entries
InterPro
Ribonuclease T2, His active site 1
Ribonuclease T2, His active site 2
Ribonuclease T2, eukaryotic
Ribonuclease T2-like superfamily
Ribonuclease T2-like

Alliance of Genome Resources

Expression

Displaying **all 4** entries
Location	References
vacuole	PMID:19332891
cytosol	PMID:19332891 PMID:26928762
extracellular region	PMID:11158587
fungal-type vacuole	PMID:24102742

Disease

Disease Ontology

Displaying **all 9** entries
DO ID	Disease Name	Source
DOID:0050861	colorectal adenocarcinoma	Alliance of Genome Resources
DOID:0081007	RNASET2-deficient cystic leukoencephalopathy	Alliance of Genome Resources
DOID:0112182	mismatch repair cancer syndrome	Alliance of Genome Resources
DOID:1324	lung cancer	Alliance of Genome Resources
DOID:1909	melanoma	Alliance of Genome Resources
DOID:234	colon adenocarcinoma	Alliance of Genome Resources
DOID:3717	gastric adenocarcinoma	Alliance of Genome Resources
DOID:3883	Lynch syndrome	Alliance of Genome Resources
DOID:5410	pulmonary neuroendocrine tumor	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 32 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	8635		HGNC:21686
Drosophila melanogaster	38885		FB:FBgn0010406
Mus musculus	68195		MGI:3702087
Caenorhabditis elegans	190096		WB:WBGene00019624
Rattus norvegicus	292306		RGD:1309918
Danio rerio	553485		ZFIN:ZDB-GENE-090819-2
Xenopus tropicalis	780173		Xenbase:XB-GENE-944135
Danio rerio	791890		ZFIN:ZDB-GENE-030131-2513
Kluyveromyces lactis	2893049	28985_0:00098a
Eremothecium gossypii ATCC 10895	4619690	284811_0:000520

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Last updated: December 9, 2024