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glutathione-disulfide reductase GLR1

Summary

Gene Symbol

GLR1

Organism

Saccharomyces cerevisiae S288C

External Links

NCBI Gene

856014

PubChem

856014

Alliance of Genome Resources

SGD:S000006012

Annotation

Keyword

3D-structure
Acetylation
Alternative initiation
Cytoplasm
Disulfide bond
FAD
Glycoprotein
Mitochondrion
NADP
Nucleus
Oxidoreductase
Peroxisome
Redox-active center
Reference proteome

Proteins

Displaying 1 entry
UniProt	Protein Name
P41921

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
glutathione metabolic process	IMP	23242256
glutathione metabolic process	IBA
glutathione metabolic process	IEA
protein glutathionylation	IGI	20074363
cellular response to oxidative stress	IMP	8951820

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glutathionylation

primary metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glutathionylation

organic substance metabolic process [inference]

glutathione metabolic process

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glutathionylation

macromolecule modification [inference]

protein modification process [inference]

protein glutathionylation

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glutathionylation

cellular process [inference]

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress

cellular response to chemical stimulus [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress

cellular detoxification [inference]

cellular oxidant detoxification

homeostatic process [inference]

cellular homeostasis [inference]

cell redox homeostasis

response to stimulus [inference]

response to stress [inference]

response to oxidative stress [inference]

cellular response to oxidative stress

cellular response to stress [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress

response to chemical [inference]

cellular response to chemical stimulus [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress

cellular response to chemical stimulus [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress

detoxification [inference]

cellular detoxification [inference]

cellular oxidant detoxification

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
nucleus	IDA	23613772
nucleus	HDA	14562095
cytoplasm	IEA
cytoplasm	HDA	14562095
mitochondrion	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

microbody [inference]

peroxisome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

microbody [inference]

peroxisome

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
glutathione-disulfide reductase (NADP) activity	IDA	19049979 7737505
glutathione-disulfide reductase (NADP) activity	IBA
glutathione-disulfide reductase (NADP) activity	IEA
oxidoreductase activity	IEA
flavin adenine dinucleotide binding	IBA

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity

oxidoreductase activity, acting on a sulfur group of donors [inference]

disulfide oxidoreductase activity [inference]

glutathione disulfide oxidoreductase activity [inference]

glutathione-disulfide reductase (NADP) activity

oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor [inference]

glutathione-disulfide reductase (NADP) activity

binding [inference]

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

NADP binding

flavin adenine dinucleotide binding

ion binding [inference]

anion binding [inference]

flavin adenine dinucleotide binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

NADP binding

flavin adenine dinucleotide binding

antioxidant activity [inference]

glutathione-disulfide reductase (NADP) activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Glutathione

Functional Category

C: Energy production and conversion
E: Amino acid transport and metabolism
T: Signal transduction mechanisms

Displaying **all 4** entries
Gene Ontology
cellular response to oxidative stress
flavin adenine dinucleotide binding
nucleotide binding
oxidoreductase activity

Displaying **all 6** entries
InterPro
FAD/NAD(P)-binding domain superfamily
FAD/NAD(P)-binding domain
FAD/NAD-linked reductase, dimerisation domain superfamily
Pyridine nucleotide-disulphide oxidoreductase, class I, active site
Pyridine nucleotide-disulphide oxidoreductase, class I
Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain

Alliance of Genome Resources

Expression

Displaying **all 5** entries
Location	References
cytoplasm	PMID:14562095
nucleus	PMID:14562095 PMID:23613772
peroxisome	PMID:36164978
mitochondrion	PMID:14562095 PMID:14576278 PMID:16823961 PMID:24769239
cytosol	PMID:23613772

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:11724	limb-girdle muscular dystrophy	Alliance of Genome Resources

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements