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glutathione-disulfide reductase GLR1

Summary

Gene Symbol

GLR1

Organism

Saccharomyces cerevisiae S288C

External Links

NCBI Gene

856014

PubChem

856014

Alliance of Genome Resources

SGD:S000006012

Annotation

Keyword

3D-structure
Acetylation
Alternative initiation
Cytoplasm
FAD
Glycoprotein
NADP
Oxidoreductase
Redox-active center
Reference proteome

Proteins

Displaying 1 entry
UniProt	Protein Name
P41921

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
cell redox homeostasis	IBA IEA IMP	23242256
cellular response to oxidative stress	IBA IMP	8951820
protein glutathionylation	IGI	20074363
cellular oxidant detoxification	IEA
glutathione metabolic process	IBA IEA IMP	23242256

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glutathionylation

primary metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glutathionylation

organic substance metabolic process [inference]

glutathione metabolic process

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glutathionylation

macromolecule modification [inference]

protein modification process [inference]

protein glutathionylation

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glutathionylation

cellular process [inference]

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress

cellular response to chemical stimulus [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress

cellular detoxification [inference]

cellular oxidant detoxification

homeostatic process [inference]

cellular homeostasis [inference]

cell redox homeostasis

response to stimulus [inference]

response to stress [inference]

response to oxidative stress [inference]

cellular response to oxidative stress

cellular response to stress [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress

response to chemical [inference]

cellular response to chemical stimulus [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress

cellular response to chemical stimulus [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress

detoxification [inference]

cellular detoxification [inference]

cellular oxidant detoxification

Displaying **all 5** entries
GO Term	Evidence Code	PMID
peroxisome	IDA	36164978
mitochondrion	HDA IBA	14562095 14576278 16823961 24769239
nucleus	HDA IDA	14562095 23613772
cytosol	IBA IDA	23613772
cytoplasm	HDA IEA	14562095

GO Hierarchy

cellular component

cellular anatomical entity [inference]

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

microbody [inference]

peroxisome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

microbody [inference]

peroxisome

Displaying **all 4** entries
GO Term	Evidence Code	PMID
NADP binding	IEA
oxidoreductase activity	IEA
glutathione-disulfide reductase (NADP) activity	IBA IDA IEA	19049979 7737505
flavin adenine dinucleotide binding	IBA IEA

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity

oxidoreductase activity, acting on a sulfur group of donors [inference]

disulfide oxidoreductase activity [inference]

glutathione disulfide oxidoreductase activity [inference]

glutathione-disulfide reductase (NADP) activity

oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor [inference]

glutathione-disulfide reductase (NADP) activity

binding [inference]

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

NADP binding

flavin adenine dinucleotide binding

ion binding [inference]

anion binding [inference]

flavin adenine dinucleotide binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

NADP binding

flavin adenine dinucleotide binding

antioxidant activity [inference]

glutathione-disulfide reductase (NADP) activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Glutathione

Functional Category

E: Amino acid transport and metabolism
I: Lipid transport and metabolism
T: Signal transduction mechanisms

Displaying **all 7** entries
Gene Ontology
cellular oxidant detoxification
cellular response to oxidative stress
flavin adenine dinucleotide binding
glutathione metabolic process
glutathione-disulfide reductase (NADP) activity
nucleotide binding
oxidoreductase activity

Displaying **all 7** entries
InterPro
FAD/NAD(P)-binding domain superfamily
FAD/NAD(P)-binding domain
FAD/NAD-linked reductase, dimerisation domain superfamily
Glutathione reductase/thioredoxin reductase-like
Pyridine nucleotide-disulphide oxidoreductase, class I, active site
Pyridine nucleotide-disulphide oxidoreductase, class I
Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain

Alliance of Genome Resources

Expression

Displaying **all 5** entries
Location	References
mitochondrion	PMID:14562095 PMID:14576278 PMID:16823961 PMID:24769239
cytoplasm	PMID:14562095
cytosol	PMID:23613772
peroxisome	PMID:36164978
nucleus	PMID:14562095 PMID:23613772

Disease

Disease Ontology

Displaying entries **1 - 10** of 35 in total

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DO ID	Disease Name	Source
DOID:0050859	hemorrhagic cystitis	Alliance of Genome Resources
DOID:0080108	myoglobinuria	Alliance of Genome Resources
DOID:0080208	metabolic dysfunction-associated steatotic liver disease	Alliance of Genome Resources
DOID:0080855	Parkinsonism	Alliance of Genome Resources
DOID:0111363	Heinz body anemia	Alliance of Genome Resources
DOID:1037	lymphoid leukemia	Alliance of Genome Resources
DOID:10652	Alzheimer's disease	Alliance of Genome Resources
DOID:10763	hypertension	Alliance of Genome Resources
DOID:11476	osteoporosis	Alliance of Genome Resources
DOID:11713	diabetic angiopathy	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 31 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources
Homo sapiens	2936		HGNC:4623
Mus musculus	14782		MGI:95804
Drosophila melanogaster	31760		FB:FBgn0020653
Drosophila melanogaster	40475		FB:FBgn0037170
Rattus norvegicus	116686		RGD:621747
Caenorhabditis elegans	175467		WB:WBGene00008117
Danio rerio	553575		ZFIN:ZDB-GENE-050522-116
Kluyveromyces lactis	2894346	28985_0:000e83
Eremothecium gossypii ATCC 10895	4623164	284811_0:00127e
Vanderwaltozyma polyspora DSM 70294	5543201	436907_0:00035a

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Summary

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Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements