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glutathione-disulfide reductase GLR1

Summary

Gene Symbol

GLR1

Organism

Saccharomyces cerevisiae S288C

External Links

NCBI Gene

856014

PubChem

856014

Alliance of Genome Resources

SGD:S000006012

Annotation

Keyword

3D-structure
Acetylation
Alternative initiation
Cytoplasm
FAD
Glycoprotein
NADP
Oxidoreductase
Redox-active center
Reference proteome

Proteins

Displaying 1 entry
UniProt	Protein Name
P41921

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
cell redox homeostasis	IBA IEA IMP	23242256
cellular response to oxidative stress	IBA IMP	8951820
protein glutathionylation	IGI	20074363
cellular oxidant detoxification	IEA
glutathione metabolic process	IBA IEA IMP	23242256

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glutathionylation

primary metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glutathionylation

organic substance metabolic process [inference]

glutathione metabolic process

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glutathionylation

macromolecule modification [inference]

protein modification process [inference]

protein glutathionylation

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glutathionylation

cellular process [inference]

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress

cellular response to chemical stimulus [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress

cellular detoxification [inference]

cellular oxidant detoxification

homeostatic process [inference]

cellular homeostasis [inference]

cell redox homeostasis

response to stimulus [inference]

response to stress [inference]

response to oxidative stress [inference]

cellular response to oxidative stress

cellular response to stress [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress

response to chemical [inference]

cellular response to chemical stimulus [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress

cellular response to chemical stimulus [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress

detoxification [inference]

cellular detoxification [inference]

cellular oxidant detoxification

Displaying **all 5** entries
GO Term	Evidence Code	PMID
peroxisome	IDA	36164978
mitochondrion	HDA IBA	14562095 14576278 16823961 24769239
nucleus	HDA IDA	14562095 23613772
cytosol	IBA IDA	23613772
cytoplasm	HDA IEA	14562095

GO Hierarchy

cellular component

cellular anatomical entity [inference]

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

microbody [inference]

peroxisome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

microbody [inference]

peroxisome

Displaying **all 4** entries
GO Term	Evidence Code	PMID
NADP binding	IEA
oxidoreductase activity	IEA
glutathione-disulfide reductase (NADP) activity	IBA IDA IEA	19049979 7737505
flavin adenine dinucleotide binding	IBA IEA

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity

oxidoreductase activity, acting on a sulfur group of donors [inference]

disulfide oxidoreductase activity [inference]

glutathione disulfide oxidoreductase activity [inference]

glutathione-disulfide reductase (NADP) activity

oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor [inference]

glutathione-disulfide reductase (NADP) activity

binding [inference]

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

NADP binding

flavin adenine dinucleotide binding

ion binding [inference]

anion binding [inference]

flavin adenine dinucleotide binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

NADP binding

flavin adenine dinucleotide binding

antioxidant activity [inference]

glutathione-disulfide reductase (NADP) activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Glutathione

Functional Category

E: Amino acid transport and metabolism
I: Lipid transport and metabolism
T: Signal transduction mechanisms

Displaying **all 7** entries
Gene Ontology
cellular oxidant detoxification
cellular response to oxidative stress
flavin adenine dinucleotide binding
glutathione metabolic process
glutathione-disulfide reductase (NADP) activity
nucleotide binding
oxidoreductase activity

Displaying **all 7** entries
InterPro
FAD/NAD(P)-binding domain superfamily
FAD/NAD(P)-binding domain
FAD/NAD-linked reductase, dimerisation domain superfamily
Glutathione reductase/thioredoxin reductase-like
Pyridine nucleotide-disulphide oxidoreductase, class I, active site
Pyridine nucleotide-disulphide oxidoreductase, class I
Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain

Alliance of Genome Resources

Expression

Displaying **all 5** entries
Location	References
mitochondrion	PMID:14562095 PMID:14576278 PMID:16823961 PMID:24769239
cytoplasm	PMID:14562095
cytosol	PMID:23613772
peroxisome	PMID:36164978
nucleus	PMID:14562095 PMID:23613772

Disease

Disease Ontology

Displaying entries **11 - 20** of 35 in total

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DO ID	Disease Name	Source
DOID:11724	limb-girdle muscular dystrophy	Alliance of Genome Resources
DOID:11758	iron deficiency anemia	Alliance of Genome Resources
DOID:12241	beta thalassemia	Alliance of Genome Resources
DOID:12556	acute kidney tubular necrosis	Alliance of Genome Resources
DOID:12858	Huntington's disease	Alliance of Genome Resources
DOID:1307	dementia	Alliance of Genome Resources
DOID:13328	diabetic cataract	Alliance of Genome Resources
DOID:224	transient cerebral ischemia	Alliance of Genome Resources
DOID:251	alcohol-induced mental disorder	Alliance of Genome Resources
DOID:3021	acute kidney failure	Alliance of Genome Resources

Ortholog

Displaying entries **21 - 30** of 31 in total

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Species	Gene ID	OrthoDB
Saccharomyces eubayanus	28934507	1080349_0:0013c9
Kazachstania naganishii CBS 8797	34523505	1071383_0:000156
Lachancea lanzarotensis	34685328	1245769_0:000898
Kluyveromyces marxianus DMKU3-1042	34714440	1003335_0:0001ce
Saccharomyces paradoxus	54634121	27291_0:001526
Zygotorulaspora mrakii	59238744	42260_0:001286
Torulaspora globosa	59323949	48254_0:0003ac
Kazachstania barnettii	64858855	61262_0:000fd9
Saccharomyces mikatae IFO 1815	80921713	226126_0:0014f2
Saccharomyces kudriavzevii IFO 1802	80927592	226230_0:0014ce

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements