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glutathione-disulfide reductase GLR1

Summary

Gene Symbol

GLR1

Organism

Saccharomyces cerevisiae S288C

External Links

NCBI Gene

856014

PubChem

856014

Alliance of Genome Resources

SGD:S000006012

Annotation

Keyword

3D-structure
Acetylation
Alternative initiation
Cytoplasm
FAD
Glycoprotein
NADP
Oxidoreductase
Redox-active center
Reference proteome

Proteins

Displaying 1 entry
UniProt	Protein Name
P41921

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
cell redox homeostasis	IBA IEA IMP	23242256
cellular response to oxidative stress	IBA IMP	8951820
protein glutathionylation	IGI	20074363
cellular oxidant detoxification	IEA
glutathione metabolic process	IBA IEA IMP	23242256

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glutathionylation

primary metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glutathionylation

organic substance metabolic process [inference]

glutathione metabolic process

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glutathionylation

macromolecule modification [inference]

protein modification process [inference]

protein glutathionylation

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glutathionylation

cellular process [inference]

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress

cellular response to chemical stimulus [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress

cellular detoxification [inference]

cellular oxidant detoxification

homeostatic process [inference]

cellular homeostasis [inference]

cell redox homeostasis

response to stimulus [inference]

response to stress [inference]

response to oxidative stress [inference]

cellular response to oxidative stress

cellular response to stress [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress

response to chemical [inference]

cellular response to chemical stimulus [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress

cellular response to chemical stimulus [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress

detoxification [inference]

cellular detoxification [inference]

cellular oxidant detoxification

Displaying **all 5** entries
GO Term	Evidence Code	PMID
peroxisome	IDA	36164978
mitochondrion	HDA IBA	14562095 14576278 16823961 24769239
nucleus	HDA IDA	14562095 23613772
cytosol	IBA IDA	23613772
cytoplasm	HDA IEA	14562095

GO Hierarchy

cellular component

cellular anatomical entity [inference]

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

microbody [inference]

peroxisome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

microbody [inference]

peroxisome

Displaying **all 4** entries
GO Term	Evidence Code	PMID
NADP binding	IEA
oxidoreductase activity	IEA
glutathione-disulfide reductase (NADP) activity	IBA IDA IEA	19049979 7737505
flavin adenine dinucleotide binding	IBA IEA

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity

oxidoreductase activity, acting on a sulfur group of donors [inference]

disulfide oxidoreductase activity [inference]

glutathione disulfide oxidoreductase activity [inference]

glutathione-disulfide reductase (NADP) activity

oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor [inference]

glutathione-disulfide reductase (NADP) activity

binding [inference]

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

NADP binding

flavin adenine dinucleotide binding

ion binding [inference]

anion binding [inference]

flavin adenine dinucleotide binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

NADP binding

flavin adenine dinucleotide binding

antioxidant activity [inference]

glutathione-disulfide reductase (NADP) activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Glutathione

Functional Category

E: Amino acid transport and metabolism
I: Lipid transport and metabolism
T: Signal transduction mechanisms

Displaying **all 7** entries
Gene Ontology
cellular oxidant detoxification
cellular response to oxidative stress
flavin adenine dinucleotide binding
glutathione metabolic process
glutathione-disulfide reductase (NADP) activity
nucleotide binding
oxidoreductase activity

Displaying **all 7** entries
InterPro
FAD/NAD(P)-binding domain superfamily
FAD/NAD(P)-binding domain
FAD/NAD-linked reductase, dimerisation domain superfamily
Glutathione reductase/thioredoxin reductase-like
Pyridine nucleotide-disulphide oxidoreductase, class I, active site
Pyridine nucleotide-disulphide oxidoreductase, class I
Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain

Alliance of Genome Resources

Expression

Displaying **all 5** entries
Location	References
mitochondrion	PMID:14562095 PMID:14576278 PMID:16823961 PMID:24769239
cytoplasm	PMID:14562095
cytosol	PMID:23613772
peroxisome	PMID:36164978
nucleus	PMID:14562095 PMID:23613772

Disease

Disease Ontology

Displaying entries **31 - 35** of 35 in total

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DO ID	Disease Name	Source
DOID:8997	polycythemia vera	Alliance of Genome Resources
DOID:9119	acute myeloid leukemia	Alliance of Genome Resources
DOID:9351	diabetes mellitus	Alliance of Genome Resources
DOID:9669	senile cataract	Alliance of Genome Resources
DOID:9952	acute lymphoblastic leukemia	Alliance of Genome Resources

Ortholog

Displaying entries **11 - 20** of 31 in total

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Species	Gene ID	OrthoDB
Vanderwaltozyma polyspora DSM 70294	5546915	436907_0:0010b1
Lachancea thermotolerans CBS 6340	8292220	559295_0:000825
Eremothecium cymbalariae DBVPG#7215	11469304	931890_0:000e5b
Naumovozyma dairenensis CBS 421	11498663	1071378_0:000b39
Torulaspora delbrueckii	11503220	4950_0:0001c4
Naumovozyma castellii CBS 4309	11526373	1064592_0:0009dc
Tetrapisispora phaffii CBS 4417	11532265	1071381_0:0001f2
Kazachstania africana CBS 2517	13882732	1071382_0:000aed
Tetrapisispora blattae CBS 6284	14497816	1071380_0:001287
Eremothecium sinecaudum	28724093	45286_0:000711

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements