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bifunctional 4-alpha-glucanotransferase/amylo-alpha-1,6-glucosidase

Summary

Gene Symbol

GDB1

Organism

Saccharomyces cerevisiae S288C

External Links

NCBI Gene

856314

PubChem

856314

Alliance of Genome Resources

SGD:S000006388

Annotation

Keyword

Cytoplasm
Direct protein sequencing
Glycogen biosynthesis
Glycosidase
Glycosyltransferase
Mitochondrion
Multifunctional enzyme
Reference proteome

Proteins

Displaying 1 entry
UniProt	Protein Name
Q06625	Glycogen debrancher

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 2** entries
GO Term	Evidence Code	PMID
glycogen biosynthetic process	IEA
glycogen catabolic process	IBA IEA IMP	11094287

GO Hierarchy

biological process

metabolic process [inference]

catabolic process [inference]

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

polysaccharide catabolic process [inference]

glucan catabolic process [inference]

glycogen catabolic process

carbohydrate catabolic process [inference]

polysaccharide catabolic process [inference]

glucan catabolic process [inference]

glycogen catabolic process

biosynthetic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

polysaccharide biosynthetic process [inference]

glucan biosynthetic process [inference]

glycogen biosynthetic process

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

polysaccharide biosynthetic process [inference]

glucan biosynthetic process [inference]

glycogen biosynthetic process

carbohydrate biosynthetic process [inference]

polysaccharide biosynthetic process [inference]

glucan biosynthetic process [inference]

glycogen biosynthetic process

cellular metabolic process [inference]

generation of precursor metabolites and energy [inference]

energy derivation by oxidation of organic compounds [inference]

energy reserve metabolic process [inference]

glycogen metabolic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

polysaccharide biosynthetic process [inference]

glucan biosynthetic process [inference]

glycogen biosynthetic process

primary metabolic process [inference]

carbohydrate metabolic process [inference]

polysaccharide metabolic process [inference]

polysaccharide biosynthetic process [inference]

glucan biosynthetic process [inference]

glycogen biosynthetic process

polysaccharide catabolic process [inference]

glucan catabolic process [inference]

glycogen catabolic process

glucan metabolic process [inference]

glycogen metabolic process [inference]

glucan biosynthetic process [inference]

glycogen biosynthetic process

glucan catabolic process [inference]

glycogen catabolic process

carbohydrate biosynthetic process [inference]

polysaccharide biosynthetic process [inference]

glucan biosynthetic process [inference]

glycogen biosynthetic process

carbohydrate catabolic process [inference]

polysaccharide catabolic process [inference]

glucan catabolic process [inference]

glycogen catabolic process

organic substance metabolic process [inference]

carbohydrate metabolic process [inference]

polysaccharide metabolic process [inference]

polysaccharide biosynthetic process [inference]

glucan biosynthetic process [inference]

glycogen biosynthetic process

polysaccharide catabolic process [inference]

glucan catabolic process [inference]

glycogen catabolic process

glucan metabolic process [inference]

glycogen metabolic process [inference]

glucan biosynthetic process [inference]

glycogen biosynthetic process

glucan catabolic process [inference]

glycogen catabolic process

carbohydrate biosynthetic process [inference]

polysaccharide biosynthetic process [inference]

glucan biosynthetic process [inference]

glycogen biosynthetic process

carbohydrate catabolic process [inference]

polysaccharide catabolic process [inference]

glucan catabolic process [inference]

glycogen catabolic process

macromolecule metabolic process [inference]

polysaccharide metabolic process [inference]

polysaccharide biosynthetic process [inference]

glucan biosynthetic process [inference]

glycogen biosynthetic process

polysaccharide catabolic process [inference]

glucan catabolic process [inference]

glycogen catabolic process

glucan metabolic process [inference]

glycogen metabolic process [inference]

glucan biosynthetic process [inference]

glycogen biosynthetic process

glucan catabolic process [inference]

glycogen catabolic process

macromolecule catabolic process [inference]

polysaccharide catabolic process [inference]

glucan catabolic process [inference]

glycogen catabolic process

macromolecule biosynthetic process [inference]

polysaccharide biosynthetic process [inference]

glucan biosynthetic process [inference]

glycogen biosynthetic process

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

polysaccharide catabolic process [inference]

glucan catabolic process [inference]

glycogen catabolic process

carbohydrate catabolic process [inference]

polysaccharide catabolic process [inference]

glucan catabolic process [inference]

glycogen catabolic process

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

polysaccharide biosynthetic process [inference]

glucan biosynthetic process [inference]

glycogen biosynthetic process

carbohydrate biosynthetic process [inference]

polysaccharide biosynthetic process [inference]

glucan biosynthetic process [inference]

glycogen biosynthetic process

cellular process [inference]

cellular metabolic process [inference]

generation of precursor metabolites and energy [inference]

energy derivation by oxidation of organic compounds [inference]

energy reserve metabolic process [inference]

glycogen metabolic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

polysaccharide biosynthetic process [inference]

glucan biosynthetic process [inference]

glycogen biosynthetic process

Displaying **all 2** entries
GO Term	Evidence Code	PMID
mitochondrion	HDA IEA	14576278 16823961
cytoplasm	HDA IEA	14562095 22842922

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytoplasm

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

Displaying entry **6 - 6** of 6 in total

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GO Term	Evidence Code	PMID
glycosyltransferase activity	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

glycosyltransferase activity

hexosyltransferase activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on glycosyl bonds

hydrolase activity, hydrolyzing O-glycosyl compounds

glucosidase activity [inference]

alpha-glucosidase activity [inference]

amylo-alpha-1,6-glucosidase activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Glycogen debranching enzyme

Functional Category

G: Carbohydrate transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
Q: Secondary metabolites biosynthesis, transport and catabolism

Displaying **all 5** entries
Gene Ontology
4-alpha-glucanotransferase activity
amylo-alpha-1,6-glucosidase activity
glycogen biosynthetic process
glycogen catabolic process
hydrolase activity

Displaying **all 8** entries
InterPro
Eukaryotic glycogen debranching enzyme, N-terminal domain
Glycogen debranching enzyme, C-terminal
Glycogen debranching enzyme, central domain
Glycogen debranching enzyme, glucanotransferase domain
Glycogen debranching enzyme
Glycoside hydrolase superfamily
Six-hairpin glycosidase superfamily
Six-hairpin glycosidase-like superfamily

Alliance of Genome Resources

Expression

Displaying **all 2** entries
Location	References
cytoplasm	PMID:14562095 PMID:22842922
mitochondrion	PMID:14576278 PMID:16823961

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:2748	glycogen storage disease III	Alliance of Genome Resources
DOID:4676	uremia	Alliance of Genome Resources

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP007017
Gene Name: bifunctional 4-alpha-glucanotransferase/amylo-alpha-1,6-glucosidase

Ortholog

Displaying entries **1 - 10** of 30 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	178		HGNC:321
Drosophila melanogaster	37435		FB:FBgn0034618
Mus musculus	77559		MGI:1924809
Caenorhabditis elegans	175091		WB:WBGene00011050
Rattus norvegicus	362029		RGD:1306376
Danio rerio	553352		ZFIN:ZDB-GENE-050309-54
Danio rerio	567798		ZFIN:ZDB-GENE-071004-6
Xenopus tropicalis	780065		Xenbase:XB-GENE-1001429
Eremothecium gossypii ATCC 10895	4620764	284811_0:000afd
Vanderwaltozyma polyspora DSM 70294	5546644	436907_0:000ff3

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: December 9, 2024