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proteasome regulatory particle base subunit RPN1

Summary

Gene Symbol

RPN1

Organism

Saccharomyces cerevisiae S288C

External Links

NCBI Gene

856422

KEGG Gene ID

sce:YHR027C

PubChem

856422

Alliance of Genome Resources

SGD:S000001069

Annotation

Keyword

3D-structure
Direct protein sequencing
Phosphoprotein
Proteasome
Reference proteome
Repeat

Proteins

Displaying 1 entry
UniProt	Protein Name
P38764	HMG-CoA reductase degradation protein 2 Proteasome non-ATPase subunit 1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 3** entries
GO Term	Evidence Code	PMID
proteasome-mediated ubiquitin-dependent protein catabolic process	IBA
regulation of protein catabolic process	IEA
ubiquitin-dependent protein catabolic process		8982460 9697412

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process

proteasome-mediated ubiquitin-dependent protein catabolic process

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

catabolic process [inference]

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

modification-dependent macromolecule catabolic process [inference]

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process

proteasome-mediated ubiquitin-dependent protein catabolic process

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process

proteasome-mediated ubiquitin-dependent protein catabolic process

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

modification-dependent macromolecule catabolic process [inference]

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process

proteasome-mediated ubiquitin-dependent protein catabolic process

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process

proteasome-mediated ubiquitin-dependent protein catabolic process

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process

proteasome-mediated ubiquitin-dependent protein catabolic process

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

modification-dependent macromolecule catabolic process [inference]

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process

proteasome-mediated ubiquitin-dependent protein catabolic process

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of catabolic process [inference]

regulation of protein catabolic process

regulation of nitrogen compound metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of protein catabolic process

regulation of macromolecule metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of protein catabolic process

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of protein catabolic process

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
proteasome complex	IEA
proteasome storage granule	IBA IDA	18504300
endoplasmic reticulum	HDA	11914276
proteasome regulatory particle, base subcomplex	IBA IDA	9741626
nucleus	HDA IBA IDA	15210724 26928762

GO Hierarchy

cellular component

protein-containing complex [inference]

proteasome regulatory particle, base subcomplex

intracellular protein-containing complex [inference]

proteasome complex

catalytic complex [inference]

peptidase complex [inference]

endopeptidase complex [inference]

proteasome complex

cellular anatomical entity [inference]

cytoplasm

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

proteasome storage granule

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

proteasome storage granule

Displaying **all 3** entries
GO Term	Evidence Code	PMID
enzyme regulator activity	IEA
protein-macromolecule adaptor activity	IPI	12198498
endopeptidase activity		8982460 9697412

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity [inference]

endopeptidase activity

catalytic activity, acting on a protein [inference]

peptidase activity [inference]

endopeptidase activity

molecular adaptor activity [inference]

protein-macromolecule adaptor activity

molecular function regulator activity [inference]

enzyme regulator activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

26S proteasome regulatory non-ATPase subunit

Functional Category

G: Carbohydrate transport and metabolism
M: Cell wall/membrane/envelope biogenesis
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
proteasome-mediated ubiquitin-dependent protein catabolic process

Displaying **all 6** entries
InterPro
26S proteasome non-ATPase regulatory subunit RPN1, C-terminal
26S proteasome regulatory complex, non-ATPase subcomplex, Rpn1 subunit
Armadillo-like helical
Armadillo-type fold
Proteasome/cyclosome repeat
RPN1, N-terminal

KEGG BRITE Database

Orthology

K03028

Name

26S proteasome regulatory subunit N1

References

Alliance of Genome Resources

Expression

Displaying **all 5** entries
Location	References
proteasome storage granule	PMID:18504300
cytoplasm	PMID:11914276
endoplasmic reticulum	PMID:11914276
nucleus	PMID:15210724 PMID:26928762
proteasome regulatory particle, base subcomplex	PMID:9741626

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:1289	neurodegenerative disease	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 29 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources
Homo sapiens	5708		HGNC:9559
Mus musculus	21762		MGI:1096584
Drosophila melanogaster	40174		FB:FBgn0028695
Caenorhabditis elegans	177455		WB:WBGene00004458
Rattus norvegicus	287984		RGD:1305752
Danio rerio	393518		ZFIN:ZDB-GENE-040426-1480
Xenopus tropicalis	548536		Xenbase:XB-GENE-972398
Kluyveromyces lactis	2894593	28985_0:000df2
Eremothecium gossypii ATCC 10895	4619599	284811_0:000372
Vanderwaltozyma polyspora DSM 70294	5544521	436907_0:000802