GlyCosmos Portal

Annotation

Keyword

Endoplasmic reticulum
Glycoprotein
Glycosidase
Metal-binding
Reference proteome
Signal
Unfolded protein response

Proteins

Displaying 1 entry
UniProt	Protein Name
P38888

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 8 in total

1

2

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GO Term	Evidence Code	PMID
carbohydrate metabolic process	IEA
mannose trimming involved in glycoprotein ERAD pathway	IBA IDA IGI IMP	19124653 21700223 27053108
positive regulation of endoplasmic reticulum unfolded protein response
protein alpha-1,2-demannosylation	IDA	21700223
endoplasmic reticulum mannose trimming	IBA IMP	27053108

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway [inference]

ubiquitin-dependent ERAD pathway [inference]

ubiquitin-dependent glycoprotein ERAD pathway

proteasome-mediated ubiquitin-dependent protein catabolic process [inference]

ubiquitin-dependent ERAD pathway [inference]

ubiquitin-dependent glycoprotein ERAD pathway

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process [inference]

ubiquitin-dependent ERAD pathway [inference]

ubiquitin-dependent glycoprotein ERAD pathway

glycoprotein metabolic process [inference]

glycoprotein catabolic process [inference]

ubiquitin-dependent glycoprotein ERAD pathway

protein deglycosylation [inference]

protein deglycosylation involved in glycoprotein catabolic process [inference]

mannose trimming involved in glycoprotein ERAD pathway

protein demannosylation [inference]

protein alpha-1,2-demannosylation

protein catabolic process [inference]

glycoprotein catabolic process [inference]

ubiquitin-dependent glycoprotein ERAD pathway

proteasomal protein catabolic process [inference]

ERAD pathway [inference]

ubiquitin-dependent ERAD pathway [inference]

ubiquitin-dependent glycoprotein ERAD pathway

proteasome-mediated ubiquitin-dependent protein catabolic process [inference]

ubiquitin-dependent ERAD pathway [inference]

ubiquitin-dependent glycoprotein ERAD pathway

protein modification process [inference]

protein glycosylation

protein deglycosylation [inference]

protein deglycosylation involved in glycoprotein catabolic process [inference]

mannose trimming involved in glycoprotein ERAD pathway

protein demannosylation [inference]

protein alpha-1,2-demannosylation

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

glycoprotein catabolic process [inference]

ubiquitin-dependent glycoprotein ERAD pathway

proteasomal protein catabolic process [inference]

ERAD pathway [inference]

ubiquitin-dependent ERAD pathway [inference]

ubiquitin-dependent glycoprotein ERAD pathway

proteasome-mediated ubiquitin-dependent protein catabolic process [inference]

ubiquitin-dependent ERAD pathway [inference]

ubiquitin-dependent glycoprotein ERAD pathway

catabolic process [inference]

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

glycoprotein catabolic process [inference]

ubiquitin-dependent glycoprotein ERAD pathway

proteasomal protein catabolic process [inference]

ERAD pathway [inference]

ubiquitin-dependent ERAD pathway [inference]

ubiquitin-dependent glycoprotein ERAD pathway

proteasome-mediated ubiquitin-dependent protein catabolic process [inference]

ubiquitin-dependent ERAD pathway [inference]

ubiquitin-dependent glycoprotein ERAD pathway

modification-dependent macromolecule catabolic process [inference]

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process [inference]

ubiquitin-dependent ERAD pathway [inference]

ubiquitin-dependent glycoprotein ERAD pathway

carbohydrate derivative catabolic process [inference]

glycoprotein catabolic process [inference]

ubiquitin-dependent glycoprotein ERAD pathway

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

glycoprotein catabolic process [inference]

ubiquitin-dependent glycoprotein ERAD pathway

proteasomal protein catabolic process [inference]

ERAD pathway [inference]

ubiquitin-dependent ERAD pathway [inference]

ubiquitin-dependent glycoprotein ERAD pathway

proteasome-mediated ubiquitin-dependent protein catabolic process [inference]

ubiquitin-dependent ERAD pathway [inference]

ubiquitin-dependent glycoprotein ERAD pathway

primary metabolic process [inference]

carbohydrate metabolic process

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway [inference]

ubiquitin-dependent ERAD pathway [inference]

ubiquitin-dependent glycoprotein ERAD pathway

proteasome-mediated ubiquitin-dependent protein catabolic process [inference]

ubiquitin-dependent ERAD pathway [inference]

ubiquitin-dependent glycoprotein ERAD pathway

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process [inference]

ubiquitin-dependent ERAD pathway [inference]

ubiquitin-dependent glycoprotein ERAD pathway

glycoprotein metabolic process [inference]

glycoprotein catabolic process [inference]

ubiquitin-dependent glycoprotein ERAD pathway

protein deglycosylation [inference]

protein deglycosylation involved in glycoprotein catabolic process [inference]

mannose trimming involved in glycoprotein ERAD pathway

protein demannosylation [inference]

protein alpha-1,2-demannosylation

protein catabolic process [inference]

glycoprotein catabolic process [inference]

ubiquitin-dependent glycoprotein ERAD pathway

proteasomal protein catabolic process [inference]

ERAD pathway [inference]

ubiquitin-dependent ERAD pathway [inference]

ubiquitin-dependent glycoprotein ERAD pathway

proteasome-mediated ubiquitin-dependent protein catabolic process [inference]

ubiquitin-dependent ERAD pathway [inference]

ubiquitin-dependent glycoprotein ERAD pathway

protein modification process [inference]

protein glycosylation

protein deglycosylation [inference]

protein deglycosylation involved in glycoprotein catabolic process [inference]

mannose trimming involved in glycoprotein ERAD pathway

protein demannosylation [inference]

protein alpha-1,2-demannosylation

glycosylation [inference]

macromolecule glycosylation [inference]

protein glycosylation

organic substance metabolic process [inference]

carbohydrate metabolic process

macromolecule metabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

glycoprotein catabolic process [inference]

ubiquitin-dependent glycoprotein ERAD pathway

proteasomal protein catabolic process [inference]

ERAD pathway [inference]

ubiquitin-dependent ERAD pathway [inference]

ubiquitin-dependent glycoprotein ERAD pathway

proteasome-mediated ubiquitin-dependent protein catabolic process [inference]

ubiquitin-dependent ERAD pathway [inference]

ubiquitin-dependent glycoprotein ERAD pathway

modification-dependent macromolecule catabolic process [inference]

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process [inference]

ubiquitin-dependent ERAD pathway [inference]

ubiquitin-dependent glycoprotein ERAD pathway

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway [inference]

ubiquitin-dependent ERAD pathway [inference]

ubiquitin-dependent glycoprotein ERAD pathway

proteasome-mediated ubiquitin-dependent protein catabolic process [inference]

ubiquitin-dependent ERAD pathway [inference]

ubiquitin-dependent glycoprotein ERAD pathway

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process [inference]

ubiquitin-dependent ERAD pathway [inference]

ubiquitin-dependent glycoprotein ERAD pathway

glycoprotein metabolic process [inference]

glycoprotein catabolic process [inference]

ubiquitin-dependent glycoprotein ERAD pathway

protein deglycosylation [inference]

protein deglycosylation involved in glycoprotein catabolic process [inference]

mannose trimming involved in glycoprotein ERAD pathway

protein demannosylation [inference]

protein alpha-1,2-demannosylation

protein catabolic process [inference]

glycoprotein catabolic process [inference]

ubiquitin-dependent glycoprotein ERAD pathway

proteasomal protein catabolic process [inference]

ERAD pathway [inference]

ubiquitin-dependent ERAD pathway [inference]

ubiquitin-dependent glycoprotein ERAD pathway

proteasome-mediated ubiquitin-dependent protein catabolic process [inference]

ubiquitin-dependent ERAD pathway [inference]

ubiquitin-dependent glycoprotein ERAD pathway

protein modification process [inference]

protein glycosylation

protein deglycosylation [inference]

protein deglycosylation involved in glycoprotein catabolic process [inference]

mannose trimming involved in glycoprotein ERAD pathway

protein demannosylation [inference]

protein alpha-1,2-demannosylation

macromolecule modification [inference]

protein modification process [inference]

protein glycosylation

protein deglycosylation [inference]

protein deglycosylation involved in glycoprotein catabolic process [inference]

mannose trimming involved in glycoprotein ERAD pathway

protein demannosylation [inference]

protein alpha-1,2-demannosylation

macromolecule glycosylation [inference]

protein glycosylation

carbohydrate derivative metabolic process [inference]

glycoprotein metabolic process [inference]

glycoprotein catabolic process [inference]

ubiquitin-dependent glycoprotein ERAD pathway

protein deglycosylation [inference]

protein deglycosylation involved in glycoprotein catabolic process [inference]

mannose trimming involved in glycoprotein ERAD pathway

protein demannosylation [inference]

protein alpha-1,2-demannosylation

carbohydrate derivative catabolic process [inference]

glycoprotein catabolic process [inference]

ubiquitin-dependent glycoprotein ERAD pathway

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway [inference]

ubiquitin-dependent ERAD pathway [inference]

ubiquitin-dependent glycoprotein ERAD pathway

proteasome-mediated ubiquitin-dependent protein catabolic process [inference]

ubiquitin-dependent ERAD pathway [inference]

ubiquitin-dependent glycoprotein ERAD pathway

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process [inference]

ubiquitin-dependent ERAD pathway [inference]

ubiquitin-dependent glycoprotein ERAD pathway

glycoprotein metabolic process [inference]

glycoprotein catabolic process [inference]

ubiquitin-dependent glycoprotein ERAD pathway

protein deglycosylation [inference]

protein deglycosylation involved in glycoprotein catabolic process [inference]

mannose trimming involved in glycoprotein ERAD pathway

protein demannosylation [inference]

protein alpha-1,2-demannosylation

protein catabolic process [inference]

glycoprotein catabolic process [inference]

ubiquitin-dependent glycoprotein ERAD pathway

proteasomal protein catabolic process [inference]

ERAD pathway [inference]

ubiquitin-dependent ERAD pathway [inference]

ubiquitin-dependent glycoprotein ERAD pathway

proteasome-mediated ubiquitin-dependent protein catabolic process [inference]

ubiquitin-dependent ERAD pathway [inference]

ubiquitin-dependent glycoprotein ERAD pathway

protein modification process [inference]

protein glycosylation

protein deglycosylation [inference]

protein deglycosylation involved in glycoprotein catabolic process [inference]

mannose trimming involved in glycoprotein ERAD pathway

protein demannosylation [inference]

protein alpha-1,2-demannosylation

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

glycoprotein catabolic process [inference]

ubiquitin-dependent glycoprotein ERAD pathway

proteasomal protein catabolic process [inference]

ERAD pathway [inference]

ubiquitin-dependent ERAD pathway [inference]

ubiquitin-dependent glycoprotein ERAD pathway

proteasome-mediated ubiquitin-dependent protein catabolic process [inference]

ubiquitin-dependent ERAD pathway [inference]

ubiquitin-dependent glycoprotein ERAD pathway

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

glycoprotein catabolic process [inference]

ubiquitin-dependent glycoprotein ERAD pathway

proteasomal protein catabolic process [inference]

ERAD pathway [inference]

ubiquitin-dependent ERAD pathway [inference]

ubiquitin-dependent glycoprotein ERAD pathway

proteasome-mediated ubiquitin-dependent protein catabolic process [inference]

ubiquitin-dependent ERAD pathway [inference]

ubiquitin-dependent glycoprotein ERAD pathway

modification-dependent macromolecule catabolic process [inference]

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process [inference]

ubiquitin-dependent ERAD pathway [inference]

ubiquitin-dependent glycoprotein ERAD pathway

carbohydrate derivative catabolic process [inference]

glycoprotein catabolic process [inference]

ubiquitin-dependent glycoprotein ERAD pathway

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

glycoprotein catabolic process [inference]

ubiquitin-dependent glycoprotein ERAD pathway

proteasomal protein catabolic process [inference]

ERAD pathway [inference]

ubiquitin-dependent ERAD pathway [inference]

ubiquitin-dependent glycoprotein ERAD pathway

proteasome-mediated ubiquitin-dependent protein catabolic process [inference]

ubiquitin-dependent ERAD pathway [inference]

ubiquitin-dependent glycoprotein ERAD pathway

cellular process [inference]

cellular response to stimulus [inference]

cellular response to stress [inference]

response to endoplasmic reticulum stress [inference]

ERAD pathway [inference]

ubiquitin-dependent ERAD pathway [inference]

ubiquitin-dependent glycoprotein ERAD pathway

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

response to endoplasmic reticulum stress [inference]

ERAD pathway [inference]

ubiquitin-dependent ERAD pathway [inference]

ubiquitin-dependent glycoprotein ERAD pathway

response to topologically incorrect protein [inference]

response to unfolded protein

response to chemical [inference]

response to organic substance [inference]

response to organonitrogen compound [inference]

ERAD pathway [inference]

ubiquitin-dependent ERAD pathway [inference]

ubiquitin-dependent glycoprotein ERAD pathway

response to glycoprotein [inference]

ubiquitin-dependent glycoprotein ERAD pathway

response to topologically incorrect protein [inference]

response to unfolded protein

response to nitrogen compound [inference]

response to organonitrogen compound [inference]

ERAD pathway [inference]

ubiquitin-dependent ERAD pathway [inference]

ubiquitin-dependent glycoprotein ERAD pathway

response to glycoprotein [inference]

ubiquitin-dependent glycoprotein ERAD pathway

response to oxygen-containing compound [inference]

response to glycoprotein [inference]

ubiquitin-dependent glycoprotein ERAD pathway

cellular response to stimulus [inference]

cellular response to stress [inference]

response to endoplasmic reticulum stress [inference]

ERAD pathway [inference]

ubiquitin-dependent ERAD pathway [inference]

ubiquitin-dependent glycoprotein ERAD pathway

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of endoplasmic reticulum unfolded protein response

regulation of endoplasmic reticulum unfolded protein response [inference]

positive regulation of endoplasmic reticulum unfolded protein response

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of endoplasmic reticulum unfolded protein response

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of endoplasmic reticulum unfolded protein response

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of endoplasmic reticulum unfolded protein response

positive regulation of response to endoplasmic reticulum stress [inference]

positive regulation of endoplasmic reticulum unfolded protein response

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of endoplasmic reticulum unfolded protein response

positive regulation of response to endoplasmic reticulum stress [inference]

positive regulation of endoplasmic reticulum unfolded protein response

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of endoplasmic reticulum unfolded protein response

regulation of endoplasmic reticulum unfolded protein response [inference]

positive regulation of endoplasmic reticulum unfolded protein response

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of endoplasmic reticulum unfolded protein response

positive regulation of response to endoplasmic reticulum stress [inference]

positive regulation of endoplasmic reticulum unfolded protein response

regulation of response to stress [inference]

regulation of cellular response to stress [inference]

regulation of response to endoplasmic reticulum stress [inference]

regulation of endoplasmic reticulum unfolded protein response [inference]

positive regulation of endoplasmic reticulum unfolded protein response

positive regulation of response to endoplasmic reticulum stress [inference]

positive regulation of endoplasmic reticulum unfolded protein response

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of endoplasmic reticulum unfolded protein response

regulation of endoplasmic reticulum unfolded protein response [inference]

positive regulation of endoplasmic reticulum unfolded protein response

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of endoplasmic reticulum unfolded protein response

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of endoplasmic reticulum unfolded protein response

positive regulation of response to endoplasmic reticulum stress [inference]

positive regulation of endoplasmic reticulum unfolded protein response

regulation of cellular response to stress [inference]

regulation of response to endoplasmic reticulum stress [inference]

regulation of endoplasmic reticulum unfolded protein response [inference]

positive regulation of endoplasmic reticulum unfolded protein response

positive regulation of response to endoplasmic reticulum stress [inference]

positive regulation of endoplasmic reticulum unfolded protein response

Displaying **all 5** entries
GO Term	Evidence Code	PMID
endoplasmic reticulum lumen	IDA IEA	19279007
endoplasmic reticulum	HDA IBA IEA	26928762
endoplasmic reticulum quality control compartment
membrane	IEA
mannosyl-oligosaccharide 1,2-alpha-mannosidase complex

GO Hierarchy

cellular component

protein-containing complex [inference]

endoplasmic reticulum protein-containing complex [inference]

mannosyl-oligosaccharide 1,2-alpha-mannosidase complex

catalytic complex [inference]

mannosyl-oligosaccharide 1,2-alpha-mannosidase complex

cellular anatomical entity [inference]

membrane

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

endoplasmic reticulum lumen

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

endoplasmic reticulum quality control compartment

Displaying entries **1 - 5** of 6 in total

1

2

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GO Term	Evidence Code	PMID
alpha-mannosidase activity	IEA
hydrolase activity, acting on glycosyl bonds	IEA
mannosyl-oligosaccharide 1,2-alpha-mannosidase activity	IDA IEA IMP	19124653 21700223 27053108
calcium ion binding	IEA
metal ion binding	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on glycosyl bonds

hydrolase activity, hydrolyzing O-glycosyl compounds [inference]

mannosidase activity [inference]

alpha-mannosidase activity

mannosyl-oligosaccharide mannosidase activity [inference]

mannosyl-oligosaccharide 1,2-alpha-mannosidase activity

binding [inference]

carbohydrate binding

ion binding [inference]

cation binding [inference]

metal ion binding

calcium ion binding

Gene Ontology information from NCBI Gene and UniProt.

Alliance of Genome Resources

Expression

Displaying **all 2** entries
Location	References
endoplasmic reticulum	PMID:26928762
endoplasmic reticulum lumen	PMID:19279007

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:1485	cystic fibrosis	Alliance of Genome Resources

Ortholog

Displaying **all 7** entries
Species	Gene ID	Alliance of Genome Resources
Caenorhabditis elegans	177857	WB:WBGene00008148
Drosophila melanogaster	34714	FB:FBgn0032480
Danio rerio	394164	ZFIN:ZDB-GENE-040426-808
Xenopus tropicalis	395034	Xenbase:XB-GENE-492908
Homo sapiens	9695	HGNC:18967
Mus musculus	192193	MGI:2180139
Rattus norvegicus	297504	RGD:1563633

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

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Acknowledgements