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solute carrier family 25 member 12

Summary

Gene Symbol

SLC25A12

Organism

Homo sapiens (human)

External Links

NCBI Gene

8604

PubChem

8604

Alliance of Genome Resources

HGNC:10982

Annotation

Keyword

3D-structure
Acetylation
Alternative splicing
Calcium
Disease variant
Metal-binding
Mitochondrion inner membrane
Reference proteome
Repeat
Transmembrane helix
Transport

Proteins

Displaying 1 entry
UniProt	Protein Name
O75746	Araceli hiperlarga Mitochondrial aspartate glutamate carrier 1 Solute carrier family 25 member 12

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
aspartate transmembrane transport	IBA IDA	11566871 19641205 24515575
L-glutamate transmembrane transport	IBA IDA	11566871 19641205 24515575
L-aspartate transmembrane transport	IEA
proton transmembrane transport	IEA
malate-aspartate shuttle	IBA IDA	11566871

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

amino acid metabolic process [inference]

alpha-amino acid metabolic process [inference]

aspartate family amino acid metabolic process

biosynthetic process [inference]

small molecule biosynthetic process [inference]

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

gluconeogenesis

organic substance biosynthetic process [inference]

carbohydrate biosynthetic process [inference]

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

gluconeogenesis

cellular metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

alpha-amino acid metabolic process [inference]

aspartate family amino acid metabolic process

primary metabolic process [inference]

carbohydrate metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

glucose metabolic process [inference]

gluconeogenesis

hexose biosynthetic process [inference]

gluconeogenesis

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

gluconeogenesis

carbohydrate biosynthetic process [inference]

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

gluconeogenesis

amino acid metabolic process [inference]

alpha-amino acid metabolic process [inference]

aspartate family amino acid metabolic process

small molecule metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

glucose metabolic process [inference]

gluconeogenesis

hexose biosynthetic process [inference]

gluconeogenesis

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

gluconeogenesis

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

alpha-amino acid metabolic process [inference]

aspartate family amino acid metabolic process

small molecule biosynthetic process [inference]

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

gluconeogenesis

organic substance metabolic process [inference]

carbohydrate metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

glucose metabolic process [inference]

gluconeogenesis

hexose biosynthetic process [inference]

gluconeogenesis

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

gluconeogenesis

carbohydrate biosynthetic process [inference]

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

gluconeogenesis

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

alpha-amino acid metabolic process [inference]

aspartate family amino acid metabolic process

organonitrogen compound metabolic process [inference]

amino acid metabolic process [inference]

alpha-amino acid metabolic process [inference]

aspartate family amino acid metabolic process

organic substance biosynthetic process [inference]

carbohydrate biosynthetic process [inference]

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

gluconeogenesis

cellular process [inference]

cellular metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

alpha-amino acid metabolic process [inference]

aspartate family amino acid metabolic process

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

proton transmembrane transport

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

proton transmembrane transport

organic acid transmembrane transport [inference]

carboxylic acid transmembrane transport [inference]

amino acid transmembrane transport [inference]

aspartate transmembrane transport

L-aspartate transmembrane transport

L-alpha-amino acid transmembrane transport [inference]

mitochondrial transmembrane transport [inference]

malate-aspartate shuttle

response to stimulus [inference]

response to chemical [inference]

response to organic substance [inference]

response to calcium ion

response to inorganic substance [inference]

response to metal ion [inference]

response to calcium ion

response to oxygen-containing compound [inference]

response to calcium ion

response to salt [inference]

response to calcium ion

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

monoatomic cation transmembrane transport [inference]

proton transmembrane transport

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

proton transmembrane transport

mitochondrial transport [inference]

mitochondrial transmembrane transport [inference]

malate-aspartate shuttle

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

proton transmembrane transport

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

proton transmembrane transport

organic acid transmembrane transport [inference]

carboxylic acid transmembrane transport [inference]

amino acid transmembrane transport [inference]

aspartate transmembrane transport

L-aspartate transmembrane transport

L-alpha-amino acid transmembrane transport [inference]

mitochondrial transmembrane transport [inference]

malate-aspartate shuttle

organic substance transport [inference]

organic anion transport [inference]

carboxylic acid transport [inference]

dicarboxylic acid transport [inference]

C4-dicarboxylate transport [inference]

aspartate transmembrane transport

L-aspartate transmembrane transport

L-glutamate import [inference]

L-glutamate transmembrane transport

amino acid transport [inference]

amino acid transmembrane transport [inference]

aspartate transmembrane transport

L-aspartate transmembrane transport

L-alpha-amino acid transmembrane transport [inference]

acidic amino acid transport [inference]

L-glutamate import [inference]

L-glutamate transmembrane transport

neutral amino acid transport

L-amino acid transport [inference]

L-glutamate import [inference]

L-glutamate transmembrane transport

L-alpha-amino acid transmembrane transport [inference]

carboxylic acid transmembrane transport [inference]

amino acid transmembrane transport [inference]

aspartate transmembrane transport

L-aspartate transmembrane transport

L-alpha-amino acid transmembrane transport [inference]

organic acid transport [inference]

carboxylic acid transport [inference]

dicarboxylic acid transport [inference]

C4-dicarboxylate transport [inference]

aspartate transmembrane transport

L-aspartate transmembrane transport

L-glutamate import [inference]

L-glutamate transmembrane transport

amino acid transport [inference]

amino acid transmembrane transport [inference]

aspartate transmembrane transport

L-aspartate transmembrane transport

L-alpha-amino acid transmembrane transport [inference]

acidic amino acid transport [inference]

L-glutamate import [inference]

L-glutamate transmembrane transport

neutral amino acid transport

L-amino acid transport [inference]

L-glutamate import [inference]

L-glutamate transmembrane transport

L-alpha-amino acid transmembrane transport [inference]

carboxylic acid transmembrane transport [inference]

amino acid transmembrane transport [inference]

aspartate transmembrane transport

L-aspartate transmembrane transport

L-alpha-amino acid transmembrane transport [inference]

organic acid transmembrane transport [inference]

carboxylic acid transmembrane transport [inference]

amino acid transmembrane transport [inference]

aspartate transmembrane transport

L-aspartate transmembrane transport

L-alpha-amino acid transmembrane transport [inference]

nitrogen compound transport [inference]

amino acid transport [inference]

amino acid transmembrane transport [inference]

aspartate transmembrane transport

L-aspartate transmembrane transport

L-alpha-amino acid transmembrane transport [inference]

acidic amino acid transport [inference]

L-glutamate import [inference]

L-glutamate transmembrane transport

neutral amino acid transport

L-amino acid transport [inference]

L-glutamate import [inference]

L-glutamate transmembrane transport

L-alpha-amino acid transmembrane transport [inference]

amide transport [inference]

L-glutamate import [inference]

L-glutamate transmembrane transport

Displaying **all 3** entries
GO Term	Evidence Code	PMID
mitochondrial inner membrane	IDA TAS	11566871
membrane	NAS	9722566
mitochondrion	HDA IDA	11566871 19641205 20833797 24515575 9722566

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

organelle membrane [inference]

organelle inner membrane [inference]

mitochondrial inner membrane

mitochondrial membrane [inference]

mitochondrial inner membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
3-sulfino-L-alanine: proton, glutamate antiporter activity	IDA	11566871
L-glutamate transmembrane transporter activity	IBA
aspartate:glutamate, proton antiporter activity	IDA	11566871 24515575
acidic amino acid transmembrane transporter activity	EXP	11566871
L-aspartate transmembrane transporter activity	IBA

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

organic acid transmembrane transporter activity [inference]

carboxylic acid transmembrane transporter activity [inference]

dicarboxylic acid transmembrane transporter activity [inference]

amino acid transmembrane transporter activity [inference]

sulfur amino acid transmembrane transporter activity [inference]

sulfur-containing amino acid secondary active transmembrane transporter activity [inference]

3-sulfino-L-alanine: proton, glutamate antiporter activity

acidic amino acid transmembrane transporter activity

neutral L-amino acid transmembrane transporter activity [inference]

3-sulfino-L-alanine: proton, glutamate antiporter activity

L-amino acid transmembrane transporter activity [inference]

amino acid:monoatomic cation antiporter activity [inference]

C4-dicarboxylate transmembrane transporter activity [inference]

organic anion transmembrane transporter activity [inference]

carboxylic acid transmembrane transporter activity [inference]

dicarboxylic acid transmembrane transporter activity [inference]

amino acid transmembrane transporter activity [inference]

sulfur amino acid transmembrane transporter activity [inference]

sulfur-containing amino acid secondary active transmembrane transporter activity [inference]

3-sulfino-L-alanine: proton, glutamate antiporter activity

acidic amino acid transmembrane transporter activity

neutral L-amino acid transmembrane transporter activity [inference]

3-sulfino-L-alanine: proton, glutamate antiporter activity

L-amino acid transmembrane transporter activity [inference]

amino acid:monoatomic cation antiporter activity [inference]

C4-dicarboxylate transmembrane transporter activity [inference]

monoatomic ion transmembrane transporter activity [inference]

monoatomic cation transmembrane transporter activity [inference]

proton transmembrane transporter activity [inference]

amino acid:monoatomic cation antiporter activity [inference]

active monoatomic ion transmembrane transporter activity [inference]

amino acid:monoatomic cation antiporter activity [inference]

inorganic molecular entity transmembrane transporter activity [inference]

inorganic cation transmembrane transporter activity [inference]

proton transmembrane transporter activity [inference]

active transmembrane transporter activity [inference]

secondary active transmembrane transporter activity [inference]

antiporter activity [inference]

amino acid:monoatomic cation antiporter activity [inference]

sulfur-containing amino acid secondary active transmembrane transporter activity [inference]

3-sulfino-L-alanine: proton, glutamate antiporter activity

active monoatomic ion transmembrane transporter activity [inference]

amino acid:monoatomic cation antiporter activity [inference]

amide transmembrane transporter activity [inference]

modified amino acid transmembrane transporter activity [inference]

3-sulfino-L-alanine: proton, glutamate antiporter activity

sulfur compound transmembrane transporter activity [inference]

sulfur amino acid transmembrane transporter activity [inference]

sulfur-containing amino acid secondary active transmembrane transporter activity [inference]

3-sulfino-L-alanine: proton, glutamate antiporter activity

salt transmembrane transporter activity [inference]

binding [inference]

protein binding

identical protein binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

calcium ion binding

Gene Ontology information from NCBI Gene and UniProt.

Disease

Disease Ontology

Displaying **all 7** entries
DO ID	Disease Name	Source
DOID:0050432	Asperger syndrome	Alliance of Genome Resources
DOID:0060041	autism spectrum disorder	Alliance of Genome Resources
DOID:0080349	developmental and epileptic encephalopathy 39	Alliance of Genome Resources
DOID:12849	autistic disorder	Alliance of Genome Resources
DOID:1852	intrahepatic cholestasis	Alliance of Genome Resources
DOID:4137	common bile duct disease	Alliance of Genome Resources
DOID:9273	citrullinemia	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of **106** in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Caenorhabditis elegans	175242	WB:WBGene00019326
Drosophila melanogaster	43616	FB:FBgn0028646
Callorhinchus milii	103176447		CALMI10350
Latimeria chalumnae	102356606		LATCH08592
Danio rerio	337675	ZFIN:ZDB-GENE-031006-11	DANRE38781
Astyanax mexicanus	103036993		ASTMX08669
Astyanax mexicanus	103047880		ASTMX00483
Ictalurus punctatus	108266328		ICTPU30963
Ictalurus punctatus	108271646		ICTPU02197
Electrophorus electricus	113570310		ELEEL04830

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