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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
RUNX family transcription factor 1
Summary
- Gene Symbol
-
- RUNX1
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Acetylation
- Activator
- Alternative splicing
- Chloride
- Chromosomal rearrangement
- DNA-binding
- Disease variant
- Methylation
- Nucleus
- Phosphoprotein
- Proto-oncogene
- Reference proteome
- Repressor
- Transcription regulation
- Proteins
| UniProt | Protein Name |
|---|---|
| Q01196 |
|
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| positive regulation of collagen biosynthetic process | ||
| neuron differentiation | ||
| peripheral nervous system neuron development | ||
| negative regulation of CD4-positive, alpha-beta T cell differentiation | ||
| positive regulation of angiogenesis |
GO Hierarchy
biological process
biological regulation [inference]
regulation of biological process [inference]
regulation of immune system process [inference]
negative regulation of immune system process [inference]
positive regulation of immune system process [inference]
regulation of leukocyte activation [inference]
negative regulation of leukocyte activation [inference]
positive regulation of leukocyte activation [inference]
regulation of lymphocyte activation [inference]
regulation of lymphocyte differentiation [inference]
regulation of T cell activation [inference]
negative regulation of lymphocyte activation [inference]
regulation of hemopoiesis [inference]
regulation of metabolic process [inference]
regulation of biosynthetic process [inference]
negative regulation of metabolic process [inference]
positive regulation of metabolic process [inference]
regulation of cellular metabolic process [inference]
regulation of nitrogen compound metabolic process [inference]
regulation of macromolecule metabolic process [inference]
regulation of primary metabolic process [inference]
positive regulation of biological process [inference]
positive regulation of immune system process [inference]
positive regulation of metabolic process [inference]
positive regulation of cellular process [inference]
positive regulation of developmental process [inference]
positive regulation of multicellular organismal process [inference]
negative regulation of biological process [inference]
negative regulation of immune system process [inference]
negative regulation of metabolic process [inference]
negative regulation of cellular process [inference]
negative regulation of developmental process [inference]
negative regulation of multicellular organismal process [inference]
regulation of developmental process [inference]
regulation of cell differentiation
negative regulation of developmental process [inference]
positive regulation of developmental process [inference]
regulation of multicellular organismal development [inference]
regulation of cellular process [inference]
regulation of cell adhesion [inference]
regulation of cellular metabolic process [inference]
regulation of cell differentiation
positive regulation of cellular process [inference]
negative regulation of cellular process [inference]
regulation of cell activation [inference]
regulation of leukocyte activation [inference]
negative regulation of leukocyte activation [inference]
positive regulation of leukocyte activation [inference]
regulation of lymphocyte activation [inference]
regulation of lymphocyte differentiation [inference]
regulation of T cell activation [inference]
negative regulation of lymphocyte activation [inference]
negative regulation of cell activation [inference]
regulation of multicellular organismal process [inference]
regulation of cell activation [inference]
regulation of leukocyte activation [inference]
negative regulation of leukocyte activation [inference]
positive regulation of leukocyte activation [inference]
regulation of lymphocyte activation [inference]
regulation of lymphocyte differentiation [inference]
regulation of T cell activation [inference]
negative regulation of lymphocyte activation [inference]
negative regulation of cell activation [inference]
positive regulation of multicellular organismal process [inference]
negative regulation of multicellular organismal process [inference]
regulation of multicellular organismal development [inference]
| GO Term | Evidence Code | PMID |
|---|---|---|
| core-binding factor complex | ||
| intracellular membrane-bounded organelle | ||
| nucleoplasm | ||
| chromatin | ||
| nucleus |
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| protein binding | ||
| transcription corepressor binding | ||
| DNA-binding transcription factor binding | ||
| RNA polymerase II cis-regulatory region sequence-specific DNA binding | ||
| DNA binding |
GO Hierarchy
OrthoDB (Group)
- Group level
- Eukaryota
- Group Name
- runt
- Functional Category
-
- C: Energy production and conversion
- O: Posttranslational modification, protein turnover, chaperones
- T: Signal transduction mechanisms
| Gene Ontology |
|---|
| ATP binding |
| chondrocyte differentiation |
| hemopoiesis |
| neuron differentiation |
| ossification |
| regulation of cell differentiation |
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0050861 | colorectal adenocarcinoma | |
| DOID:10534 | stomach cancer | |
| DOID:1380 | endometrial cancer | |
| DOID:289 | endometriosis | |
| DOID:3033 | colon signet ring adenocarcinoma | |
| DOID:3525 | middle cerebral artery infarction | |
| DOID:3748 | esophagus squamous cell carcinoma | |
| DOID:3908 | lung non-small cell carcinoma | |
| DOID:3910 | lung adenocarcinoma | |
| DOID:4928 | intrahepatic cholangiocarcinoma |
Ortholog
| Species | Gene ID | OrthoDB | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|---|
| 12394 | MGI:99852 | MOUSE17968 | ||
| 31883 | FB:FBgn0002576 | |||
| 50662 | RGD:2283 | RATNO04350 | ||
| 58126 | ZFIN:ZDB-GENE-000605-1 | DANRE18572 | ||
| 172243 | WB:WBGene00004393 | |||
| 379657 | Xenbase:XB-GENE-864949 | |||
| 487746 | CANLF12851 | |||
| 529631 | BOVIN15565 | |||
| 696749 | MACMU32002 | |||
| 100049631 | TAKRU49134 |
