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phospholipid phosphatase 2

Summary

Gene Symbol

PLPP2

Aliases

LPP2
PAP-2c

Organism

Homo sapiens (human)

External Links

NCBI Gene

8612

HGNC

9230

KEGG Gene ID

hsa:8612

PubChem

8612

Alliance of Genome Resources

HGNC:9230

Annotation

Keyword

Alternative splicing
Cell membrane
Endoplasmic reticulum
Endosome
Glycoprotein
Hydrolase
Lipid metabolism
Reference proteome
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
O43688	Lipid phosphate phosphohydrolase 2 PAP2-gamma Phosphatidate phosphohydrolase type 2c Phosphatidic acid phosphatase 2c

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
sphingosine metabolic process	IDA	9705349
phospholipid dephosphorylation	IBA IDA	16467304 9705349
signal transduction	IBA
ceramide metabolic process	IDA	9705349
sphingolipid catabolic process

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

amide metabolic process [inference]

ceramide metabolic process

organonitrogen compound metabolic process [inference]

sphingolipid metabolic process [inference]

sphingoid metabolic process [inference]

sphingosine metabolic process

organonitrogen compound catabolic process [inference]

sphingolipid catabolic process

catabolic process [inference]

cellular catabolic process [inference]

cellular lipid catabolic process [inference]

membrane lipid catabolic process [inference]

sphingolipid catabolic process

organic substance catabolic process [inference]

lipid catabolic process [inference]

cellular lipid catabolic process [inference]

membrane lipid catabolic process [inference]

sphingolipid catabolic process

organonitrogen compound catabolic process [inference]

sphingolipid catabolic process

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process

dephosphorylation [inference]

phospholipid dephosphorylation

organophosphate metabolic process [inference]

phospholipid metabolic process

cellular catabolic process [inference]

cellular lipid catabolic process [inference]

membrane lipid catabolic process [inference]

sphingolipid catabolic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

sphingolipid metabolic process [inference]

sphingoid metabolic process [inference]

sphingosine metabolic process

membrane lipid catabolic process [inference]

sphingolipid catabolic process

phospholipid metabolic process

lipid modification [inference]

phospholipid dephosphorylation

cellular lipid catabolic process [inference]

membrane lipid catabolic process [inference]

sphingolipid catabolic process

primary metabolic process [inference]

lipid metabolic process [inference]

lipid catabolic process [inference]

cellular lipid catabolic process [inference]

membrane lipid catabolic process [inference]

sphingolipid catabolic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

sphingolipid metabolic process [inference]

sphingoid metabolic process [inference]

sphingosine metabolic process

membrane lipid catabolic process [inference]

sphingolipid catabolic process

phospholipid metabolic process

lipid modification [inference]

phospholipid dephosphorylation

cellular lipid catabolic process [inference]

membrane lipid catabolic process [inference]

sphingolipid catabolic process

small molecule metabolic process [inference]

alcohol metabolic process [inference]

polyol metabolic process [inference]

diol metabolic process [inference]

sphingosine metabolic process

organic substance metabolic process [inference]

lipid metabolic process [inference]

lipid catabolic process [inference]

cellular lipid catabolic process [inference]

membrane lipid catabolic process [inference]

sphingolipid catabolic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

sphingolipid metabolic process [inference]

sphingoid metabolic process [inference]

sphingosine metabolic process

membrane lipid catabolic process [inference]

sphingolipid catabolic process

phospholipid metabolic process

lipid modification [inference]

phospholipid dephosphorylation

cellular lipid catabolic process [inference]

membrane lipid catabolic process [inference]

sphingolipid catabolic process

organophosphate metabolic process [inference]

phospholipid metabolic process

organonitrogen compound metabolic process [inference]

sphingolipid metabolic process [inference]

sphingoid metabolic process [inference]

sphingosine metabolic process

organonitrogen compound catabolic process [inference]

sphingolipid catabolic process

organic substance catabolic process [inference]

lipid catabolic process [inference]

cellular lipid catabolic process [inference]

membrane lipid catabolic process [inference]

sphingolipid catabolic process

organonitrogen compound catabolic process [inference]

sphingolipid catabolic process

organic hydroxy compound metabolic process [inference]

alcohol metabolic process [inference]

polyol metabolic process [inference]

diol metabolic process [inference]

sphingosine metabolic process

cellular process [inference]

signal transduction

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process

dephosphorylation [inference]

phospholipid dephosphorylation

organophosphate metabolic process [inference]

phospholipid metabolic process

cellular catabolic process [inference]

cellular lipid catabolic process [inference]

membrane lipid catabolic process [inference]

sphingolipid catabolic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

sphingolipid metabolic process [inference]

sphingoid metabolic process [inference]

sphingosine metabolic process

membrane lipid catabolic process [inference]

sphingolipid catabolic process

phospholipid metabolic process

lipid modification [inference]

phospholipid dephosphorylation

cellular lipid catabolic process [inference]

membrane lipid catabolic process [inference]

sphingolipid catabolic process

biological regulation [inference]

regulation of biological process [inference]

regulation of cellular process [inference]

signal transduction

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
endoplasmic reticulum	IDA	16467304
endoplasmic reticulum membrane	IEA
plasma membrane	IBA IDA TAS	16467304
membrane	IDA	9705349
early endosome	IDA	16467304

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

plasma membrane

organelle membrane [inference]

endoplasmic reticulum membrane

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

endosome membrane [inference]

early endosome membrane

bounding membrane of organelle [inference]

endosome membrane [inference]

early endosome membrane

plasma membrane region [inference]

plasma membrane raft [inference]

caveola

membrane microdomain [inference]

membrane raft [inference]

plasma membrane raft [inference]

caveola

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

early endosome

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

early endosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

early endosome

Displaying **all 4** entries
GO Term	Evidence Code	PMID
phosphatidate phosphatase activity	IBA IDA	16467304 9705349
ceramide-1-phosphate phosphatase activity	IDA	9705349
protein binding	IPI	25416956 25910212 32296183
sphingosine-1-phosphate phosphatase activity	IDA TAS	9705349

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

phosphoric ester hydrolase activity [inference]

phosphatase activity [inference]

lipid phosphatase activity [inference]

binding [inference]

protein binding

Gene Ontology information from NCBI Gene and UniProt.

KEGG BRITE Database

Orthology

K01080

Name

phosphatidate phosphatase [EC:3.1.3.4]

References

Rhea

RHEA:27429

H₂O + a 1,2-diacyl-sn-glycero-3-phosphate

a 1,2-diacyl-sn-glycerol + phosphate

Enzyme

3.1.3.4

PMID

RHEA:36239

H₂O + 1-O-alkyl-2-acyl-sn-glycero-3-phosphate

phosphate + 1-O-alkyl-2-acyl-sn-glycerol

Enzyme

3.1.3.4

Disease

Disease Ontology

Displaying **all 7** entries
DO ID	Disease Name	Source
DOID:0050865	tongue squamous cell carcinoma	DisGeNET
DOID:1115	sarcoma	DisGeNET
DOID:162	cancer	DisGeNET DisGeNET DisGeNET
DOID:1749	squamous cell carcinoma	DisGeNET
DOID:305	carcinoma	DisGeNET
DOID:4015	sarcomatoid carcinoma	DisGeNET
DOID:4766	embryoma	DisGeNET

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP001580
Gene Name: phosphatidic acid phosphatase type 2C

Ortholog

Displaying entries **1 - 10** of 88 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Caenorhabditis elegans	173734	WB:WBGene00018756
Drosophila melanogaster	35966	FB:FBgn0016078
Drosophila melanogaster	40468	FB:FBgn0037163
Drosophila melanogaster	40469	FB:FBgn0037164
Drosophila melanogaster	40470	FB:FBgn0037165
Drosophila melanogaster	40471	FB:FBgn0037166
Drosophila melanogaster	40472	FB:FBgn0037167
Drosophila melanogaster	53558	FB:FBgn0041087
Ciona intestinalis	100177985		CIOIN10630
Callorhinchus milii	103182070		CALMI24289