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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
RUNX family transcription factor 3
Summary
- Gene Symbol
-
- RUNX3
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Activator
- Alternative splicing
- Cytoplasm
- DNA-binding
- Isopeptide bond
- Nucleus
- Phosphoprotein
- Reference proteome
- Transcription regulation
- Ubl conjugation
- Proteins
| UniProt | Protein Name |
|---|---|
| Q13761 |
|
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| neuron differentiation | ||
| peripheral nervous system neuron development | ||
| negative regulation of cell cycle | ||
| negative regulation of CD4-positive, alpha-beta T cell differentiation | ||
| protein phosphorylation |
GO Hierarchy
biological process
biological regulation [inference]
regulation of biological process [inference]
regulation of immune system process [inference]
negative regulation of immune system process [inference]
positive regulation of immune system process [inference]
regulation of leukocyte activation [inference]
negative regulation of leukocyte activation [inference]
positive regulation of leukocyte activation [inference]
regulation of lymphocyte activation [inference]
regulation of lymphocyte differentiation [inference]
regulation of T cell activation [inference]
negative regulation of lymphocyte activation [inference]
regulation of hemopoiesis [inference]
regulation of metabolic process [inference]
regulation of biosynthetic process [inference]
negative regulation of metabolic process [inference]
positive regulation of metabolic process [inference]
regulation of cellular metabolic process [inference]
regulation of nitrogen compound metabolic process [inference]
regulation of macromolecule metabolic process [inference]
regulation of primary metabolic process [inference]
positive regulation of biological process [inference]
positive regulation of immune system process [inference]
positive regulation of metabolic process [inference]
positive regulation of cellular process [inference]
positive regulation of multicellular organismal process [inference]
negative regulation of biological process [inference]
negative regulation of immune system process [inference]
negative regulation of metabolic process [inference]
negative regulation of cellular process [inference]
negative regulation of multicellular organismal process [inference]
regulation of developmental process [inference]
regulation of cell differentiation
regulation of multicellular organismal development [inference]
regulation of cellular process [inference]
regulation of cell adhesion [inference]
regulation of cellular metabolic process [inference]
regulation of cell differentiation
positive regulation of cellular process [inference]
negative regulation of cellular process [inference]
regulation of cell activation [inference]
regulation of leukocyte activation [inference]
negative regulation of leukocyte activation [inference]
positive regulation of leukocyte activation [inference]
regulation of lymphocyte activation [inference]
regulation of lymphocyte differentiation [inference]
regulation of T cell activation [inference]
negative regulation of lymphocyte activation [inference]
negative regulation of cell activation [inference]
regulation of multicellular organismal process [inference]
regulation of cell activation [inference]
regulation of leukocyte activation [inference]
negative regulation of leukocyte activation [inference]
positive regulation of leukocyte activation [inference]
regulation of lymphocyte activation [inference]
regulation of lymphocyte differentiation [inference]
regulation of T cell activation [inference]
negative regulation of lymphocyte activation [inference]
negative regulation of cell activation [inference]
positive regulation of multicellular organismal process [inference]
negative regulation of multicellular organismal process [inference]
regulation of multicellular organismal development [inference]
| GO Term | Evidence Code | PMID |
|---|---|---|
| core-binding factor complex | ||
| intracellular membrane-bounded organelle | ||
| nucleoplasm | ||
| chromatin | ||
| nucleus |
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| protein binding | ||
| transcription corepressor binding | ||
| RNA polymerase II cis-regulatory region sequence-specific DNA binding | ||
| sequence-specific double-stranded DNA binding | ||
| DNA-binding transcription factor activity, RNA polymerase II-specific |
GO Hierarchy
OrthoDB (Group)
- Group level
- Eukaryota
- Group Name
- runt
- Functional Category
-
- C: Energy production and conversion
- O: Posttranslational modification, protein turnover, chaperones
- T: Signal transduction mechanisms
| Gene Ontology |
|---|
| ATP binding |
| chondrocyte differentiation |
| hemopoiesis |
| neuron differentiation |
| ossification |
| regulation of cell differentiation |
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0050589 | inflammatory bowel disease | |
| DOID:0060037 | developmental disorder of mental health | |
| DOID:0060250 | idiopathic scoliosis | |
| DOID:10534 | stomach cancer | |
| DOID:11054 | urinary bladder cancer | |
| DOID:1612 | breast cancer | |
| DOID:1793 | pancreatic cancer | |
| DOID:2152 | ovary epithelial cancer | |
| DOID:2394 | ovarian cancer | |
| DOID:2841 | asthma |
Ortholog
| Species | Gene ID | OrthoDB | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|---|
| 12399 | MGI:102672 | MOUSE40816 | ||
| 33051 | FB:FBgn0259162 | |||
| 33059 | FB:FBgn0003300 | |||
| 58127 | ZFIN:ZDB-GENE-000605-2 | |||
| 156726 | RGD:620082 | RATNO32985 | ||
| 172243 | WB:WBGene00004393 | |||
| 456633 | 9598_0:000205 | PANTR20281 | ||
| 617389 | BOVIN25171 | |||
| 719447 | MACMU21691 | |||
| 4379817 | FB:FBgn0083981 |
