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ATP binding cassette subfamily B member 11

Summary

Gene Symbol

ABCB11

Organism

Homo sapiens (human)

External Links

NCBI Gene

8647

PubChem

8647

Alliance of Genome Resources

HGNC:42

Annotation

Keyword

3D-structure
ATP-binding
Cell membrane
Disease variant
Endosome
Glycoprotein
Intrahepatic cholestasis
Lipid transport
Phosphoprotein
Reference proteome
Repeat
Translocase
Transmembrane helix
Ubl conjugation

Proteins

Displaying 1 entry
UniProt	Protein Name
O95342	ATP-binding cassette sub-family B member 11

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 22 in total

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GO Term	Evidence Code	PMID
xenobiotic transmembrane transport	IMP ISS	15901796 18245269
canalicular bile acid transport	IBA IDA IMP ISS	20398791 22262466 32203132
response to organic cyclic compound	IEA
carbohydrate transmembrane transport	IEA
xenobiotic export from cell	IMP ISS	18245269

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein ubiquitination

biosynthetic process [inference]

cellular biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

bile acid biosynthetic process

small molecule biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

bile acid biosynthetic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

steroid biosynthetic process [inference]

bile acid biosynthetic process

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

bile acid biosynthetic process

organic cyclic compound biosynthetic process [inference]

steroid biosynthetic process [inference]

bile acid biosynthetic process

organic hydroxy compound biosynthetic process [inference]

bile acid biosynthetic process

cellular metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

bile acid biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process

bile acid metabolic process

bile acid biosynthetic process

monocarboxylic acid biosynthetic process [inference]

bile acid biosynthetic process

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

bile acid biosynthetic process

xenobiotic metabolic process

cellular biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

bile acid biosynthetic process

cellular lipid metabolic process [inference]

fatty acid metabolic process

primary metabolic process [inference]

lipid metabolic process [inference]

steroid metabolic process [inference]

steroid biosynthetic process [inference]

bile acid biosynthetic process

bile acid metabolic process

bile acid biosynthetic process

lipid biosynthetic process [inference]

steroid biosynthetic process [inference]

bile acid biosynthetic process

cellular lipid metabolic process [inference]

fatty acid metabolic process

protein metabolic process [inference]

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein ubiquitination

small molecule metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

bile acid biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process

bile acid metabolic process

bile acid biosynthetic process

monocarboxylic acid biosynthetic process [inference]

bile acid biosynthetic process

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

bile acid biosynthetic process

small molecule biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

bile acid biosynthetic process

organic substance metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

bile acid biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process

bile acid metabolic process

bile acid biosynthetic process

monocarboxylic acid biosynthetic process [inference]

bile acid biosynthetic process

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

bile acid biosynthetic process

lipid metabolic process [inference]

steroid metabolic process [inference]

steroid biosynthetic process [inference]

bile acid biosynthetic process

bile acid metabolic process

bile acid biosynthetic process

lipid biosynthetic process [inference]

steroid biosynthetic process [inference]

bile acid biosynthetic process

cellular lipid metabolic process [inference]

fatty acid metabolic process

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein ubiquitination

macromolecule modification [inference]

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein ubiquitination

organic cyclic compound metabolic process [inference]

steroid metabolic process [inference]

steroid biosynthetic process [inference]

bile acid biosynthetic process

bile acid metabolic process

bile acid biosynthetic process

organic cyclic compound biosynthetic process [inference]

steroid biosynthetic process [inference]

bile acid biosynthetic process

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein ubiquitination

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

steroid biosynthetic process [inference]

bile acid biosynthetic process

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

bile acid biosynthetic process

organic cyclic compound biosynthetic process [inference]

steroid biosynthetic process [inference]

bile acid biosynthetic process

organic hydroxy compound biosynthetic process [inference]

bile acid biosynthetic process

organic hydroxy compound metabolic process [inference]

bile acid metabolic process

bile acid biosynthetic process

organic hydroxy compound biosynthetic process [inference]

bile acid biosynthetic process

cellular process [inference]

signal transduction [inference]

bile acid signaling pathway

cellular metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

bile acid biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process

bile acid metabolic process

bile acid biosynthetic process

monocarboxylic acid biosynthetic process [inference]

bile acid biosynthetic process

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

bile acid biosynthetic process

xenobiotic metabolic process

cellular biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

bile acid biosynthetic process

cellular lipid metabolic process [inference]

fatty acid metabolic process

transmembrane transport

export from cell [inference]

xenobiotic export from cell

homeostatic process [inference]

chemical homeostasis [inference]

lipid homeostasis

phospholipid homeostasis

sterol homeostasis [inference]

cholesterol homeostasis

response to stimulus [inference]

response to stress [inference]

response to oxidative stress

response to endogenous stimulus [inference]

response to hormone [inference]

response to estrogen

response to chemical [inference]

response to organic substance [inference]

response to hormone [inference]

response to estrogen

response to organic cyclic compound

response to alcohol [inference]

response to ethanol

response to oxygen-containing compound [inference]

response to alcohol [inference]

response to ethanol

localization [inference]

establishment of localization [inference]

transport [inference]

xenobiotic transport [inference]

secretion [inference]

canalicular bile acid transport

transmembrane transport

organic substance transport [inference]

lipid transport [inference]

bile acid and bile salt transport

canalicular bile acid transport

carbohydrate transport [inference]

carbohydrate transmembrane transport

organic anion transport [inference]

carboxylic acid transport [inference]

monocarboxylic acid transport [inference]

bile acid and bile salt transport

canalicular bile acid transport

organic acid transport [inference]

carboxylic acid transport [inference]

monocarboxylic acid transport [inference]

bile acid and bile salt transport

canalicular bile acid transport

organic hydroxy compound transport [inference]

bile acid and bile salt transport

canalicular bile acid transport

export from cell [inference]

xenobiotic export from cell

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of catabolic process [inference]

regulation of cellular catabolic process [inference]

regulation of fatty acid beta-oxidation

regulation of lipid catabolic process [inference]

regulation of fatty acid beta-oxidation

regulation of cellular metabolic process [inference]

regulation of cellular ketone metabolic process [inference]

regulation of fatty acid metabolic process [inference]

regulation of fatty acid oxidation [inference]

regulation of fatty acid beta-oxidation

regulation of cellular catabolic process [inference]

regulation of fatty acid beta-oxidation

regulation of bile acid metabolic process

regulation of small molecule metabolic process [inference]

regulation of cellular ketone metabolic process [inference]

regulation of fatty acid metabolic process [inference]

regulation of fatty acid oxidation [inference]

regulation of fatty acid beta-oxidation

regulation of bile acid metabolic process

regulation of primary metabolic process [inference]

regulation of lipid metabolic process [inference]

regulation of fatty acid metabolic process [inference]

regulation of fatty acid oxidation [inference]

regulation of fatty acid beta-oxidation

regulation of steroid metabolic process [inference]

regulation of bile acid metabolic process

regulation of lipid catabolic process [inference]

regulation of fatty acid beta-oxidation

regulation of localization [inference]

regulation of transport [inference]

regulation of organic acid transport [inference]

positive regulation of organic acid transport [inference]

positive regulation of bile acid secretion

regulation of bile acid secretion [inference]

positive regulation of bile acid secretion

regulation of secretion [inference]

positive regulation of secretion [inference]

positive regulation of bile acid secretion

regulation of bile acid secretion [inference]

positive regulation of bile acid secretion

positive regulation of transport [inference]

positive regulation of organic acid transport [inference]

positive regulation of bile acid secretion

positive regulation of secretion [inference]

positive regulation of bile acid secretion

positive regulation of biological process [inference]

positive regulation of transport [inference]

positive regulation of organic acid transport [inference]

positive regulation of bile acid secretion

positive regulation of secretion [inference]

positive regulation of bile acid secretion

regulation of cellular process [inference]

signal transduction [inference]

bile acid signaling pathway

regulation of cellular metabolic process [inference]

regulation of cellular ketone metabolic process [inference]

regulation of fatty acid metabolic process [inference]

regulation of fatty acid oxidation [inference]

regulation of fatty acid beta-oxidation

regulation of cellular catabolic process [inference]

regulation of fatty acid beta-oxidation

regulation of bile acid metabolic process

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
recycling endosome	ISS
membrane
intercellular canaliculus	IEA
apical plasma membrane	IBA IMP ISS	15791618
plasma membrane	IDA IMP TAS	20010382 22262466 24643070 29507376 30431138

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cell surface

membrane

plasma membrane

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

endosome membrane [inference]

recycling endosome membrane

bounding membrane of organelle [inference]

Golgi membrane

endosome membrane [inference]

recycling endosome membrane

plasma membrane region [inference]

cell junction [inference]

anchoring junction [inference]

cell-cell junction [inference]

intercellular canaliculus

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

recycling endosome

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

recycling endosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

recycling endosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular canaliculus

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
protein binding	IPI	22262466 32296183
ABC-type bile acid transporter activity	IBA IDA IMP ISS TAS	15791618 15901796 18985798 32203132
canalicular bile acid transmembrane transporter activity	IBA IDA IMP ISS	22262466 24711118 32203132
ATP hydrolysis activity	IEA
carbohydrate transmembrane transporter activity	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on acid anhydrides [inference]

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [inference]

pyrophosphatase activity [inference]

ribonucleoside triphosphate phosphatase activity [inference]

ATP hydrolysis activity

transporter activity [inference]

lipid transporter activity [inference]

bile acid transmembrane transporter activity

ATPase-coupled lipid transmembrane transporter activity [inference]

ABC-type bile acid transporter activity

transmembrane transporter activity [inference]

organic acid transmembrane transporter activity [inference]

ATPase-coupled organic acid transmembrane transporter activity [inference]

ATPase-coupled carboxylic acid transmembrane transporter activity [inference]

ATPase-coupled monocarboxylic acid transmembrane transporter activity [inference]

ABC-type bile acid transporter activity

carboxylic acid transmembrane transporter activity [inference]

monocarboxylic acid transmembrane transporter activity [inference]

bile acid transmembrane transporter activity

ATPase-coupled monocarboxylic acid transmembrane transporter activity [inference]

ABC-type bile acid transporter activity

ATPase-coupled carboxylic acid transmembrane transporter activity [inference]

ATPase-coupled monocarboxylic acid transmembrane transporter activity [inference]

ABC-type bile acid transporter activity

organic anion transmembrane transporter activity [inference]

carboxylic acid transmembrane transporter activity [inference]

monocarboxylic acid transmembrane transporter activity [inference]

bile acid transmembrane transporter activity

ATPase-coupled monocarboxylic acid transmembrane transporter activity [inference]

ABC-type bile acid transporter activity

ATPase-coupled carboxylic acid transmembrane transporter activity [inference]

ATPase-coupled monocarboxylic acid transmembrane transporter activity [inference]

ABC-type bile acid transporter activity

carbohydrate transmembrane transporter activity

active transmembrane transporter activity [inference]

primary active transmembrane transporter activity [inference]

ATPase-coupled transmembrane transporter activity [inference]

ATPase-coupled organic acid transmembrane transporter activity [inference]

ATPase-coupled carboxylic acid transmembrane transporter activity [inference]

ATPase-coupled monocarboxylic acid transmembrane transporter activity [inference]

ABC-type bile acid transporter activity

ATPase-coupled lipid transmembrane transporter activity [inference]

ABC-type bile acid transporter activity

ABC-type transporter activity [inference]

xenobiotic transmembrane transporter activity [inference]

ABC-type xenobiotic transporter activity

organic hydroxy compound transmembrane transporter activity [inference]

bile acid transmembrane transporter activity

binding [inference]

protein binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ATP-dependent activity [inference]

ATPase-coupled transmembrane transporter activity [inference]

ATPase-coupled organic acid transmembrane transporter activity [inference]

ATPase-coupled carboxylic acid transmembrane transporter activity [inference]

ATPase-coupled monocarboxylic acid transmembrane transporter activity [inference]

ABC-type bile acid transporter activity

ATPase-coupled lipid transmembrane transporter activity [inference]

ABC-type bile acid transporter activity

ABC-type transporter activity [inference]

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

ABC

Functional Category

J: Translation, ribosomal structure and biogenesis
K: Transcription
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
ABC-type transporter activity
ATP binding
nucleotide binding

Displaying **all 6** entries
InterPro
AAA+ ATPase domain
ABC transporter type 1, transmembrane domain superfamily
ABC transporter type 1, transmembrane domain
ABC transporter-like, ATP-binding domain
ABC transporter-like, conserved site
P-loop containing nucleoside triphosphate hydrolase

Disease

Disease Ontology

Displaying **all 7** entries
DO ID	Disease Name	Source
DOID:0070222	progressive familial intrahepatic cholestasis 2	Alliance of Genome Resources
DOID:0070232	benign recurrent intrahepatic cholestasis 2	Alliance of Genome Resources
DOID:12351	alcoholic hepatitis	Alliance of Genome Resources
DOID:13580	cholestasis	Alliance of Genome Resources
DOID:1485	cystic fibrosis	Alliance of Genome Resources
DOID:1852	intrahepatic cholestasis	Alliance of Genome Resources
DOID:5082	liver cirrhosis	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 99 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Mus musculus	27413		MGI:1351619	MOUSE32013
Drosophila melanogaster	36582		FB:FBgn0010241
Rattus norvegicus	83569		RGD:619930	RATNO28108
Caenorhabditis elegans	172262		WB:WBGene00003996
Caenorhabditis elegans	178215		WB:WBGene00003995
Caenorhabditis elegans	180165		WB:WBGene00004003
Caenorhabditis elegans	181326		WB:WBGene00003997
Pan troglodytes	470717	9598_0:000c92		PANTR29050
Canis lupus familiaris	488390			CANLF13939
Bos taurus	531150			BOVIN24130

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OrthoDB (Group)

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Acknowledgements