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eukaryotic translation initiation factor 3 subunit B

Summary

Gene Symbol

EIF3B

Organism

Homo sapiens (human)

External Links

NCBI Gene

8662

PubChem

8662

Alliance of Genome Resources

HGNC:3280

JoGo

EIF3B

TogoVar

EIF3B

Annotation

Keyword

3D-structure
Acetylation
Alternative splicing
Cytoplasm
Initiation factor
Phosphoprotein
Proteomics identification
RNA-binding
Reference proteome
Repeat
WD repeat

Proteins

Displaying 1 entry
UniProt	Protein Name
P55884	Eukaryotic translation initiation factor 3 subunit 9 Prt1 homolog eIF-3-eta eIF3 p110 eIF3 p116

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
formation of cytoplasmic translation initiation complex	NAS	16920360
translational initiation	IC	17322308 18599441
translational initiation	IDA	17581632 8995410
translational initiation	IBA
regulation of translational initiation	IDA	8995410

GO Hierarchy

biological process

metabolic process [inference]

cellular metabolic process [inference]

translational initiation

cellular process [inference]

cellular metabolic process [inference]

translational initiation

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

protein-containing complex assembly [inference]

protein-RNA complex assembly [inference]

formation of cytoplasmic translation initiation complex

protein-containing complex organization [inference]

protein-containing complex assembly [inference]

protein-RNA complex assembly [inference]

formation of cytoplasmic translation initiation complex

protein-RNA complex organization [inference]

protein-RNA complex assembly [inference]

formation of cytoplasmic translation initiation complex

viral process [inference]

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

post-transcriptional regulation of gene expression [inference]

regulation of translation [inference]

regulation of translational initiation

regulation of cellular metabolic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

post-transcriptional regulation of gene expression [inference]

regulation of translation [inference]

regulation of translational initiation

regulation of nitrogen compound metabolic process [inference]

regulation of amide metabolic process [inference]

regulation of translation [inference]

regulation of translational initiation

regulation of protein metabolic process [inference]

regulation of translation [inference]

regulation of translational initiation

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

post-transcriptional regulation of gene expression [inference]

regulation of translation [inference]

regulation of translational initiation

regulation of protein metabolic process [inference]

regulation of translation [inference]

regulation of translational initiation

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of translation [inference]

regulation of translational initiation

regulation of cellular process [inference]

regulation of cellular metabolic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

post-transcriptional regulation of gene expression [inference]

regulation of translation [inference]

regulation of translational initiation

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
cytosol	TAS
eukaryotic translation initiation factor 3 complex	IDA	17322308 17581632 18599441 25849773 8995410
eukaryotic translation initiation factor 3 complex	IBA
eukaryotic translation initiation factor 3 complex	IPI	17322308
cytoplasmic stress granule	IDA	17984221

GO Hierarchy

cellular component

protein-containing complex [inference]

eukaryotic translation initiation factor 3 complex

eukaryotic translation initiation factor 3 complex, eIF3m

ribonucleoprotein complex [inference]

translation preinitiation complex [inference]

cellular anatomical entity [inference]

cytosol

cell junction [inference]

synapse

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

ribonucleoprotein granule [inference]

cytoplasmic ribonucleoprotein granule [inference]

cytoplasmic stress granule

intracellular organelle [inference]

intracellular non-membrane-bounded organelle [inference]

ribonucleoprotein granule [inference]

cytoplasmic ribonucleoprotein granule [inference]

cytoplasmic stress granule

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

supramolecular complex [inference]

ribonucleoprotein granule [inference]

cytoplasmic ribonucleoprotein granule [inference]

cytoplasmic stress granule

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
RNA binding	IDA	25849773 27462815
translation initiation factor activity	IC	17322308 18599441
translation initiation factor activity	IDA	17581632 25849773 8995410
translation initiation factor activity	IBA
protein binding	IPI	11169732 14688252 15567442 18423201 18599441 18628297 19245811 19615732 21986499 23023399 24396066 24423872 30021884 33961781 34819669 35271311 39251607

GO Hierarchy

molecular function

binding [inference]

protein binding

translation initiation factor binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

RNA binding

translation regulator activity, nucleic acid binding [inference]

translation factor activity, RNA binding [inference]

translation initiation factor activity

translation regulator activity [inference]

translation regulator activity, nucleic acid binding [inference]

translation factor activity, RNA binding [inference]

translation initiation factor activity

molecular adaptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

eukaryotic translation initiation factor 3 subunit

Functional Category

G: Carbohydrate transport and metabolism
J: Translation, ribosomal structure and biogenesis
K: Transcription

Displaying **all 3** entries
Gene Ontology
cytoplasmic translational initiation
formation of cytoplasmic translation initiation complex
translation initiation factor binding

Displaying **all 7** entries
InterPro
Eukaryotic translation initiation factor 3 subunit B
Nucleotide-binding alpha-beta plait domain superfamily
RNA recognition motif domain
RNA-binding domain superfamily
Translation initiation factor, beta propellor-like domain
WD40/YVTN repeat-like-containing domain superfamily
eIF3B, RNA recognition motif