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polypeptide N-acetylgalactosaminyltransferase 4

Summary

Gene Symbol

GALNT4

Aliases

GalNAc-T4
polypeptide GalNAc transferase 4

Organism

Homo sapiens (human)

External Links

NCBI Gene

8693

GGDB ID

gg090

HGNC

4126

mRNA

NM_003774

map

12q21.3-q22

Protein

NP_003765

OMIM

603565

KEGG Gene ID

hsa:8693

PubChem

8693

Alliance of Genome Resources

HGNC:4126

Annotation

Keyword

3D-structure
Alternative splicing
Disulfide bond
Glycoprotein
Glycosyltransferase
Golgi apparatus
Lectin
Manganese
Metal-binding
Reference proteome
Signal-anchor
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q8N4A0	Polypeptide GalNAc transferase 4 Protein-UDP acetylgalactosaminyltransferase 4 UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 4

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 4** entries
GO Term	Evidence Code	PMID
protein O-linked glycosylation via threonine	IDA	29208955 9804815
protein O-linked glycosylation	IBA
O-glycan processing	TAS
protein O-linked glycosylation via serine	IDA	9804815

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation [inference]

protein O-linked glycosylation

peptidyl-amino acid modification [inference]

peptidyl-serine modification [inference]

protein O-linked glycosylation via serine

peptidyl-threonine modification [inference]

protein O-linked glycosylation via threonine

primary metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation [inference]

protein O-linked glycosylation

peptidyl-amino acid modification [inference]

peptidyl-serine modification [inference]

protein O-linked glycosylation via serine

peptidyl-threonine modification [inference]

protein O-linked glycosylation via threonine

glycosylation [inference]

macromolecule glycosylation [inference]

protein glycosylation [inference]

protein O-linked glycosylation

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation [inference]

protein O-linked glycosylation

peptidyl-amino acid modification [inference]

peptidyl-serine modification [inference]

protein O-linked glycosylation via serine

peptidyl-threonine modification [inference]

protein O-linked glycosylation via threonine

macromolecule modification [inference]

protein modification process [inference]

protein glycosylation [inference]

protein O-linked glycosylation

peptidyl-amino acid modification [inference]

peptidyl-serine modification [inference]

protein O-linked glycosylation via serine

peptidyl-threonine modification [inference]

protein O-linked glycosylation via threonine

macromolecule glycosylation [inference]

protein glycosylation [inference]

protein O-linked glycosylation

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation [inference]

protein O-linked glycosylation

peptidyl-amino acid modification [inference]

peptidyl-serine modification [inference]

protein O-linked glycosylation via serine

peptidyl-threonine modification [inference]

protein O-linked glycosylation via threonine

Displaying **all 4** entries
GO Term	Evidence Code	PMID
Golgi apparatus	IDA	12506059
Golgi membrane	TAS
perinuclear region of cytoplasm	IDA	12506059
extracellular exosome	HDA	19199708

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

organelle membrane [inference]

bounding membrane of organelle [inference]

Golgi membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

Golgi apparatus

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

perinuclear region of cytoplasm

Displaying **all 4** entries
GO Term	Evidence Code	PMID
protein binding	IPI	28514442 32814053 33961781
manganese ion binding	IDA	29208955
polypeptide N-acetylgalactosaminyltransferase activity	IBA IDA TAS	29208955 9804815
carbohydrate binding	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

glycosyltransferase activity [inference]

UDP-glycosyltransferase activity [inference]

acetylgalactosaminyltransferase activity [inference]

polypeptide N-acetylgalactosaminyltransferase activity

hexosyltransferase activity [inference]

acetylgalactosaminyltransferase activity [inference]

polypeptide N-acetylgalactosaminyltransferase activity

catalytic activity, acting on a protein [inference]

polypeptide N-acetylgalactosaminyltransferase activity

binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

manganese ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Polypeptide N-acetylgalactosaminyltransferase

Functional Category

E: Amino acid transport and metabolism
G: Carbohydrate transport and metabolism
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
polypeptide N-acetylgalactosaminyltransferase activity
protein O-linked glycosylation
transferase activity

Displaying **all 5** entries
InterPro
Glycosyltransferase 2-like
N-acetylgalactosaminyltransferase
Nucleotide-diphospho-sugar transferases
Ricin B, lectin domain
Ricin B-like lectins

GlycoGene Database (GGDB)

GGDB ID

gg090

Gene Symbol

GALNT4

Orthologous Gene

Displaying **all 4** entries
Species	Protein	mRNA
Drosophila melanogaster	NP_725602	NM_166188
Rattus norvegicus	NP_001020224	NM_001025053
Caenorhabditis elegans	NP_499721	NM_067320
Mus musculus	NP_056552	NM_015737

KEGG BRITE Database

Orthology

K00710

Name

polypeptide N-acetylgalactosaminyltransferase [EC:2.4.1.41]

References

9295285

Rhea

RHEA:23956

UDP-N-acetyl-α-D-galactosamine

H⁺ + UDP

Enzyme

2.4.1.41

PMID

RHEA:52424

UDP-N-acetyl-α-D-galactosamine

H⁺ + UDP

Enzyme

2.4.1.41

PMID

Ortholog

Displaying entries **1 - 10** of 36 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Mus musculus	14426		MGI:894692	MOUSE00974
Caenorhabditis elegans	176736		WB:WBGene00001630
Drosophila melanogaster	246627		FB:FBgn0050463
Xenopus laevis	432105		Xenbase:XB-GENE-5803711
Rattus norvegicus	500826		RGD:1564589
Danio rerio	503760		ZFIN:ZDB-GENE-050306-41	DANRE15026
Xenopus tropicalis	780162		Xenbase:XB-GENE-5803663
Pongo abelii	100172056	9601_0:0033e8		PONAB05580
Meleagris gallopavo	100542413			MELGA00390
Oreochromis niloticus	100695295			ORENI41586

GlyTouCan

GlyComb

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UniCarb-DR

LM-GlycoRepo

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Other Information

Tools

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Summary

External Links

Annotation

OrthoDB (Group)

GlycoGene Database (GGDB)

KEGG BRITE Database

International Collaboration

Acknowledgements