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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
diacylglycerol O-acyltransferase 1
Summary
- Gene Symbol
-
- DGAT1
- Aliases
-
- ARGP1
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Acyltransferase
- Disease variant
- Endoplasmic reticulum
- Lipid metabolism
- Phosphoprotein
- Reference proteome
- Transmembrane helix
- Proteins
| UniProt | Protein Name |
|---|---|
| O75907 |
|
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| long-chain fatty-acyl-CoA metabolic process | ||
| diacylglycerol metabolic process | ||
| lipid storage | ||
| retinol metabolic process |
GO Hierarchy
biological process
metabolic process [inference]
nitrogen compound metabolic process [inference]
cellular metabolic process [inference]
primary metabolic process [inference]
small molecule metabolic process [inference]
organic substance metabolic process [inference]
cellular process [inference]
cellular metabolic process [inference]
| GO Term | Evidence Code | PMID |
|---|---|---|
| endoplasmic reticulum membrane | ||
| plasma membrane |
|
|
| membrane | ||
| specific granule membrane |
|
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| diacylglycerol O-acyltransferase activity | ||
| 2-acylglycerol O-acyltransferase activity | ||
| acyltransferase activity |
|
|
| protein binding | ||
| retinol O-fatty-acyltransferase activity |
GO Hierarchy
Human Protein Atlas
Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.
KEGG BRITE Database
Rhea
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:13250 | diarrhea | |
| DOID:13579 | kwashiorkor | |
| DOID:14118 | familial lipoprotein lipase deficiency | |
| DOID:162 | cancer | |
| DOID:1697 | ichthyosis | |
| DOID:1699 | obsolete congenital ichthyosiform erythroderma | |
| DOID:1837 | diabetic ketoacidosis | |
| DOID:1883 | hepatitis C | |
| DOID:1936 | atherosclerosis | |
| DOID:2348 | arteriosclerotic cardiovascular disease |
- The Human Phenotype Ontology
| HPO ID | HPO Term |
|---|---|
| HP:0000007 | Autosomal recessive inheritance |
| HP:0001508 | Failure to thrive |
| HP:0002013 | Vomiting |
| HP:0002014 | Diarrhea |
| HP:0002243 | Protein-losing enteropathy |
| HP:0003073 | Hypoalbuminemia |
| HP:0003077 | Hyperlipidemia |
| HP:0003124 | Hypercholesterolemia |
| HP:0003623 | Neonatal onset |
| HP:0011473 | Villous atrophy |
| Disease ID | Disease Name |
|---|---|
| OMIM:615863 |
|
PubChem Disease
- MedGen Diseases
- OMIM Phenotypes
- KEGG Diseases
LIPID MAPS Gene / Proteome Database
- LMPD ID
- LMP006743
- Gene Name
- diacylglycerol O-acyltransferase 1
Ortholog
| Species | Gene ID | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|
| 179540 | WB:WBGene00010408 | ||
| 44887 | FB:FBgn0004797 | ||
| 325875 | ZFIN:ZDB-GENE-030131-4600 | DANRE16391 | |
| 436731 | ZFIN:ZDB-GENE-040718-158 | ||
| 108257065 | ICTPU19412 | ||
| 106570407 | SALSA33092 | ||
| 106588986 | SALSA97007 | ||
| 115174058 | SALTR106632 | ||
| 115175571 | SALTR05040 | ||
| 115536307 | GADMO34439 |
