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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
diacylglycerol O-acyltransferase 1
Summary
- Gene Symbol
-
- DGAT1
- Aliases
-
- ARGP1
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Acyltransferase
- Disease variant
- Endoplasmic reticulum
- Lipid metabolism
- Phosphoprotein
- Reference proteome
- Transmembrane helix
- Proteins
| UniProt | Protein Name |
|---|---|
| O75907 |
|
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| long-chain fatty-acyl-CoA metabolic process | ||
| diacylglycerol metabolic process | ||
| lipid storage | ||
| retinol metabolic process |
GO Hierarchy
biological process
metabolic process [inference]
nitrogen compound metabolic process [inference]
cellular metabolic process [inference]
primary metabolic process [inference]
small molecule metabolic process [inference]
organic substance metabolic process [inference]
cellular process [inference]
cellular metabolic process [inference]
| GO Term | Evidence Code | PMID |
|---|---|---|
| endoplasmic reticulum membrane | ||
| plasma membrane |
|
|
| membrane | ||
| specific granule membrane |
|
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| diacylglycerol O-acyltransferase activity | ||
| 2-acylglycerol O-acyltransferase activity | ||
| acyltransferase activity |
|
|
| protein binding | ||
| retinol O-fatty-acyltransferase activity |
GO Hierarchy
Human Protein Atlas
Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.
KEGG BRITE Database
Rhea
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:2349 | arteriosclerosis | |
| DOID:2590 | familial nephrotic syndrome | |
| DOID:2734 | keratosis follicularis | |
| DOID:2738 | pseudoxanthoma elasticum | |
| DOID:3146 | lipid metabolism disorder | |
| DOID:318 | progressive muscular atrophy | |
| DOID:322 | myelitis | |
| DOID:332 | amyotrophic lateral sclerosis | |
| DOID:3393 | coronary artery disease | |
| DOID:374 | nutrition disease |
- The Human Phenotype Ontology
| HPO ID | HPO Term |
|---|---|
| HP:0000007 | Autosomal recessive inheritance |
| HP:0001508 | Failure to thrive |
| HP:0002013 | Vomiting |
| HP:0002014 | Diarrhea |
| HP:0002243 | Protein-losing enteropathy |
| HP:0003073 | Hypoalbuminemia |
| HP:0003077 | Hyperlipidemia |
| HP:0003124 | Hypercholesterolemia |
| HP:0003623 | Neonatal onset |
| HP:0011473 | Villous atrophy |
| Disease ID | Disease Name |
|---|---|
| OMIM:615863 |
|
PubChem Disease
- MedGen Diseases
- OMIM Phenotypes
- KEGG Diseases
LIPID MAPS Gene / Proteome Database
- LMPD ID
- LMP006743
- Gene Name
- diacylglycerol O-acyltransferase 1
Ortholog
| Species | Gene ID | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|
| 101079602 | TAKRU05635 | ||
| 105731485 | AOTNA38189 | ||
| 110214325 | PHACI01164 | ||
| 101976287 | ICTTR09317 | ||
| 101605602 | JACJA07585 | ||
| 102424179 | MYOLU17766 | ||
| 121469281 | TAEGU01718 | ||
| 103237618 | CHLSB17484 | ||
| 104671680 | RHIRO29953 | ||
| 114600142 | PODMU23228 |
