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serpin family H member 1

Summary

Gene Symbol

SERPINH1

Organism

Homo sapiens (human)

External Links

NCBI Gene

871

PubChem

871

Alliance of Genome Resources

HGNC:1546

Annotation

Keyword

Acetylation
Chaperone
Collagen
Endoplasmic reticulum
Glycoprotein
Osteogenesis imperfecta
Phosphoprotein
Reference proteome
Signal
Stress response

Proteins

Displaying **all 2** entries
UniProt	Protein Name
A8K259	Collagen-binding protein
P50454	47 kDa heat shock protein Arsenic-transactivated protein 3 Cell proliferation-inducing gene 14 protein Collagen-binding protein Rheumatoid arthritis-related antigen RA-A47

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
chondrocyte development involved in endochondral bone morphogenesis	IEA
response to unfolded protein	TAS	10023073 1309665
collagen fibril organization	IBA
collagen biosynthetic process	IEA
protein maturation	IEA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein maturation

biosynthetic process [inference]

collagen biosynthetic process

collagen metabolic process [inference]

collagen biosynthetic process

primary metabolic process [inference]

protein metabolic process [inference]

protein maturation

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein maturation

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein maturation

cellular process [inference]

cellular developmental process [inference]

cell development [inference]

chondrocyte development [inference]

chondrocyte development involved in endochondral bone morphogenesis

cellular component organization or biogenesis [inference]

cellular component organization [inference]

extracellular structure organization [inference]

extracellular matrix organization [inference]

collagen fibril organization

external encapsulating structure organization [inference]

extracellular matrix organization [inference]

collagen fibril organization

supramolecular fiber organization [inference]

collagen fibril organization

developmental process [inference]

anatomical structure development [inference]

cell development [inference]

chondrocyte development [inference]

chondrocyte development involved in endochondral bone morphogenesis

cellular developmental process [inference]

cell development [inference]

chondrocyte development [inference]

chondrocyte development involved in endochondral bone morphogenesis

response to stimulus [inference]

response to stress [inference]

response to topologically incorrect protein [inference]

response to unfolded protein

response to chemical [inference]

response to organic substance [inference]

response to topologically incorrect protein [inference]

response to unfolded protein

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
collagen trimer
extracellular space	IEA
endoplasmic reticulum	NAS	7656593
endoplasmic reticulum	IDA
endoplasmic reticulum	IBA

GO Hierarchy

cellular component

protein-containing complex [inference]

collagen trimer

cellular anatomical entity [inference]

extracellular space

membrane [inference]

membrane microdomain [inference]

membrane raft

external encapsulating structure [inference]

extracellular matrix [inference]

collagen-containing extracellular matrix

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

endoplasmic reticulum lumen

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

Displaying **all 5** entries
GO Term	Evidence Code	PMID
RNA binding	HDA	22658674
serine-type endopeptidase inhibitor activity	IBA
protein binding	IPI	32814053
collagen binding	NAS	7656593
unfolded protein binding	IEA

GO Hierarchy

molecular function

binding [inference]

protein binding

unfolded protein binding

protein-containing complex binding [inference]

collagen binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

RNA binding

molecular function regulator activity [inference]

enzyme regulator activity [inference]

enzyme inhibitor activity [inference]

peptidase inhibitor activity [inference]

endopeptidase inhibitor activity [inference]

serine-type endopeptidase inhibitor activity

peptidase regulator activity [inference]

peptidase inhibitor activity [inference]

endopeptidase inhibitor activity [inference]

serine-type endopeptidase inhibitor activity

endopeptidase regulator activity [inference]

endopeptidase inhibitor activity [inference]

serine-type endopeptidase inhibitor activity

molecular function inhibitor activity [inference]

enzyme inhibitor activity [inference]

peptidase inhibitor activity [inference]

endopeptidase inhibitor activity [inference]

serine-type endopeptidase inhibitor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

serpin

Functional Category

M: Cell wall/membrane/envelope biogenesis
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
serine-type endopeptidase inhibitor activity

Displaying **all 6** entries
InterPro
Serpin domain
Serpin family
Serpin superfamily, domain 1
Serpin superfamily, domain 2
Serpin superfamily
Serpin, conserved site

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0110346	osteogenesis imperfecta type 10	Alliance of Genome Resources
DOID:0111144	preterm premature rupture of the membranes	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of **106** in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Drosophila melanogaster	183	FB:FBgn0036969
Xenopus tropicalis	871	Xenbase:XB-GENE-1005105
Mus musculus	12406	Xenbase:XB-GENE-1005105	MOUSE54981
Drosophila melanogaster	24179	FB:FBgn0036970
Rattus norvegicus	29345	Xenbase:XB-GENE-1005105	RATNO16122
Danio rerio	30449		DANRE08302
Danio rerio	40234	ZFIN:ZDB-GENE-080219-21
Drosophila melanogaster	284293	FB:FBgn0037772
Sus scrofa	396773		PIGXX35012
Pan troglodytes	466899		PANTR03863

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Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements