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carbonyl reductase 3

Summary

Gene Symbol

CBR3

Aliases

SDR21C2
short chain dehydrogenase/reductase family 21C, member 2

Organism

Homo sapiens (human)

External Links

NCBI Gene

874

HGNC

1549

KEGG Gene ID

hsa:874

PubChem

874

Alliance of Genome Resources

HGNC:1549

Annotation

Keyword

3D-structure
Acetylation
Cytoplasm
NADP
Oxidoreductase
Phosphoprotein
Reference proteome

Proteins

Displaying **all 2** entries
UniProt	Protein Name
V9HW40
O75828	NADPH-dependent carbonyl reductase 3 Quinone reductase CBR3 Short chain dehydrogenase/reductase family 21C member 2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 3** entries
GO Term	Evidence Code	PMID
phylloquinone catabolic process	IEA
xenobiotic metabolic process
cognition	IMP	23227193

GO Hierarchy

biological process

metabolic process [inference]

catabolic process [inference]

cellular catabolic process [inference]

vitamin catabolic process [inference]

fat-soluble vitamin catabolic process [inference]

vitamin K catabolic process [inference]

phylloquinone catabolic process

ketone catabolic process [inference]

quinone catabolic process [inference]

vitamin K catabolic process [inference]

phylloquinone catabolic process

small molecule catabolic process [inference]

vitamin catabolic process [inference]

fat-soluble vitamin catabolic process [inference]

vitamin K catabolic process [inference]

phylloquinone catabolic process

ketone catabolic process [inference]

quinone catabolic process [inference]

vitamin K catabolic process [inference]

phylloquinone catabolic process

organic substance catabolic process [inference]

ketone catabolic process [inference]

quinone catabolic process [inference]

vitamin K catabolic process [inference]

phylloquinone catabolic process

cellular metabolic process [inference]

xenobiotic metabolic process

cellular ketone metabolic process [inference]

ketone catabolic process [inference]

quinone catabolic process [inference]

vitamin K catabolic process [inference]

phylloquinone catabolic process

quinone metabolic process [inference]

vitamin K metabolic process [inference]

phylloquinone metabolic process [inference]

phylloquinone catabolic process

vitamin K catabolic process [inference]

phylloquinone catabolic process

quinone catabolic process [inference]

vitamin K catabolic process [inference]

phylloquinone catabolic process

cellular catabolic process [inference]

vitamin catabolic process [inference]

fat-soluble vitamin catabolic process [inference]

vitamin K catabolic process [inference]

phylloquinone catabolic process

ketone catabolic process [inference]

quinone catabolic process [inference]

vitamin K catabolic process [inference]

phylloquinone catabolic process

small molecule metabolic process [inference]

vitamin metabolic process [inference]

fat-soluble vitamin metabolic process [inference]

fat-soluble vitamin catabolic process [inference]

vitamin K catabolic process [inference]

phylloquinone catabolic process

vitamin K metabolic process [inference]

phylloquinone metabolic process [inference]

phylloquinone catabolic process

vitamin K catabolic process [inference]

phylloquinone catabolic process

vitamin catabolic process [inference]

fat-soluble vitamin catabolic process [inference]

vitamin K catabolic process [inference]

phylloquinone catabolic process

cellular ketone metabolic process [inference]

ketone catabolic process [inference]

quinone catabolic process [inference]

vitamin K catabolic process [inference]

phylloquinone catabolic process

quinone metabolic process [inference]

vitamin K metabolic process [inference]

phylloquinone metabolic process [inference]

phylloquinone catabolic process

vitamin K catabolic process [inference]

phylloquinone catabolic process

quinone catabolic process [inference]

vitamin K catabolic process [inference]

phylloquinone catabolic process

small molecule catabolic process [inference]

vitamin catabolic process [inference]

fat-soluble vitamin catabolic process [inference]

vitamin K catabolic process [inference]

phylloquinone catabolic process

ketone catabolic process [inference]

quinone catabolic process [inference]

vitamin K catabolic process [inference]

phylloquinone catabolic process

organic substance metabolic process [inference]

cellular ketone metabolic process [inference]

ketone catabolic process [inference]

quinone catabolic process [inference]

vitamin K catabolic process [inference]

phylloquinone catabolic process

quinone metabolic process [inference]

vitamin K metabolic process [inference]

phylloquinone metabolic process [inference]

phylloquinone catabolic process

vitamin K catabolic process [inference]

phylloquinone catabolic process

quinone catabolic process [inference]

vitamin K catabolic process [inference]

phylloquinone catabolic process

organic substance catabolic process [inference]

ketone catabolic process [inference]

quinone catabolic process [inference]

vitamin K catabolic process [inference]

phylloquinone catabolic process

cellular process [inference]

cellular metabolic process [inference]

xenobiotic metabolic process

cellular ketone metabolic process [inference]

ketone catabolic process [inference]

quinone catabolic process [inference]

vitamin K catabolic process [inference]

phylloquinone catabolic process

quinone metabolic process [inference]

vitamin K metabolic process [inference]

phylloquinone metabolic process [inference]

phylloquinone catabolic process

vitamin K catabolic process [inference]

phylloquinone catabolic process

quinone catabolic process [inference]

vitamin K catabolic process [inference]

phylloquinone catabolic process

cellular catabolic process [inference]

vitamin catabolic process [inference]

fat-soluble vitamin catabolic process [inference]

vitamin K catabolic process [inference]

phylloquinone catabolic process

ketone catabolic process [inference]

quinone catabolic process [inference]

vitamin K catabolic process [inference]

phylloquinone catabolic process

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

cognition

Displaying **all 3** entries
GO Term	Evidence Code	PMID
cytosol	IDA TAS	18493841
extracellular space	HDA	22664934
nucleoplasm	IDA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

Displaying **all 5** entries
GO Term	Evidence Code	PMID
NADPH dehydrogenase (quinone) activity	IDA	19841672
NADPH binding	IDA	18493841
carbonyl reductase (NADPH) activity	IBA IDA TAS	18493841
protein binding	IPI	25910212 31515488 32296183
3-keto sterol reductase activity	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

oxidoreductase activity, acting on CH-OH group of donors [inference]

oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [inference]

oxidoreductase activity, acting on NAD(P)H [inference]

oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor [inference]

NAD(P)H dehydrogenase (quinone) activity [inference]

NADPH dehydrogenase (quinone) activity

binding [inference]

protein binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

NADP binding [inference]

NADPH binding

ion binding [inference]

anion binding [inference]

NADPH binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

NADP binding [inference]

NADPH binding

Gene Ontology information from NCBI Gene and UniProt.

Human Protein Atlas

ENSG00000159231

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

KEGG BRITE Database

Orthology

K00084

Name

carbonyl reductase 3 [EC:1.1.1.184]

References

15537833

Rhea

a secondary alcohol + NADP⁺

H⁺ + a ketone + NADPH

Enzyme

PMID

a quinone + H⁺ + NADPH

a quinol + NADP⁺

Enzyme

PMID

Disease

Disease Ontology

Displaying entries **1 - 10** of 18 in total

1

2

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DO ID	Disease Name	Source
DOID:0050700	cardiomyopathy	DisGeNET
DOID:11984	hypertrophic cardiomyopathy	DisGeNET
DOID:12932	endomyocardial fibrosis	DisGeNET
DOID:1612	breast cancer	DisGeNET DisGeNET DisGeNET
DOID:162	cancer	DisGeNET
DOID:2394	ovarian cancer	DisGeNET
DOID:3347	osteosarcoma	DisGeNET DisGeNET
DOID:3361	childhood osteosarcoma	DisGeNET
DOID:3376	bone osteosarcoma	DisGeNET DisGeNET
DOID:3459	breast carcinoma	DisGeNET DisGeNET

Ortholog

Displaying entries **1 - 10** of 65 in total

1

2

3

4

5

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Next ›

Last »
Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Caenorhabditis elegans	177888	WB:WBGene00000975
Caenorhabditis elegans	183832	WB:WBGene00008332
Caenorhabditis elegans	183833	WB:WBGene00008333
Caenorhabditis elegans	183834	WB:WBGene00008334
Caenorhabditis elegans	183835	WB:WBGene00008335
Caenorhabditis elegans	183836	WB:WBGene00008336
Caenorhabditis elegans	184742	WB:WBGene00008985
Caenorhabditis elegans	184743	WB:WBGene00008986
Caenorhabditis elegans	188051	WB:WBGene00011424
Caenorhabditis elegans	3565013	WB:WBGene00022809

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Last updated: August 19, 2024