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ADAM metallopeptidase domain 15

Summary

Gene Symbol

ADAM15

Organism

Homo sapiens (human)

External Links

NCBI Gene

8751

PubChem

8751

Alliance of Genome Resources

HGNC:193

Annotation

Keyword

Alternative splicing
Angiogenesis
Cell adhesion
Cell junction
Cleavage on pair of basic residues
Collagen degradation
Cytoplasmic vesicle
Disulfide bond
EGF-like domain
Flagellum
Glycoprotein
Metal-binding
Metalloprotease
Phosphoprotein
Reference proteome
SH3-binding
Signal
Transmembrane helix
Zinc
Zymogen

Proteins

Displaying 1 entry
UniProt	Protein Name
Q13444	Metalloprotease RGD disintegrin protein Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 15 Metargidin

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **16 - 18** of 18 in total

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GO Term	Evidence Code	PMID
tissue regeneration	IEA
integrin-mediated signaling pathway	IBA IMP	22505472
angiogenesis	IEA

GO Hierarchy

biological process

immune system process [inference]

immune response [inference]

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis

catabolic process [inference]

collagen catabolic process

collagen metabolic process [inference]

collagen catabolic process

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

proteolysis

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis

cellular process [inference]

cell adhesion [inference]

cell-substrate adhesion [inference]

cell-matrix adhesion

signal transduction [inference]

cell surface receptor signaling pathway [inference]

integrin-mediated signaling pathway

cell death [inference]

programmed cell death [inference]

apoptotic process

cellular developmental process [inference]

cell differentiation [inference]

mesenchymal cell differentiation [inference]

epithelial to mesenchymal transition [inference]

cardiac epithelial to mesenchymal transition

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to lipid [inference]

cellular response to phorbol 13-acetate 12-myristate

cellular response to alcohol [inference]

cellular response to phorbol 13-acetate 12-myristate

cellular response to oxygen-containing compound [inference]

cellular response to alcohol [inference]

cellular response to phorbol 13-acetate 12-myristate

cellular response to ketone [inference]

cellular response to phorbol 13-acetate 12-myristate

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component disassembly [inference]

extracellular matrix disassembly

extracellular structure organization [inference]

extracellular matrix organization [inference]

extracellular matrix disassembly

external encapsulating structure organization [inference]

extracellular matrix organization [inference]

extracellular matrix disassembly

reproductive process [inference]

developmental process involved in reproduction [inference]

reproductive structure development [inference]

gonad development [inference]

male gonad development

developmental process [inference]

developmental process involved in reproduction [inference]

reproductive structure development [inference]

gonad development [inference]

male gonad development

anatomical structure formation involved in morphogenesis [inference]

angiogenesis

anatomical structure development [inference]

regeneration [inference]

tissue regeneration

animal organ development [inference]

gonad development [inference]

male gonad development

reproductive structure development [inference]

gonad development [inference]

male gonad development

cellular developmental process [inference]

cell differentiation [inference]

mesenchymal cell differentiation [inference]

epithelial to mesenchymal transition [inference]

cardiac epithelial to mesenchymal transition

growth [inference]

developmental growth [inference]

tissue regeneration

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

defense response to other organism [inference]

innate immune response

response to stimulus [inference]

response to stress [inference]

response to hypoxia [inference]

response to hypobaric hypoxia

defense response [inference]

defense response to other organism [inference]

innate immune response

immune response [inference]

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

defense response to other organism [inference]

innate immune response

response to biotic stimulus [inference]

response to tumor cell [inference]

immune response to tumor cell

response to external biotic stimulus [inference]

response to other organism [inference]

defense response to other organism [inference]

innate immune response

response to abiotic stimulus [inference]

response to oxygen levels [inference]

response to decreased oxygen levels [inference]

response to hypoxia [inference]

response to hypobaric hypoxia

response to chemical [inference]

response to organic substance [inference]

response to lipid [inference]

cellular response to lipid [inference]

cellular response to phorbol 13-acetate 12-myristate

response to phorbol 13-acetate 12-myristate [inference]

cellular response to phorbol 13-acetate 12-myristate

cellular response to organic substance [inference]

cellular response to lipid [inference]

cellular response to phorbol 13-acetate 12-myristate

cellular response to alcohol [inference]

cellular response to phorbol 13-acetate 12-myristate

response to alcohol [inference]

cellular response to alcohol [inference]

cellular response to phorbol 13-acetate 12-myristate

response to phorbol 13-acetate 12-myristate [inference]

cellular response to phorbol 13-acetate 12-myristate

response to ketone [inference]

cellular response to ketone [inference]

cellular response to phorbol 13-acetate 12-myristate

response to phorbol 13-acetate 12-myristate [inference]

cellular response to phorbol 13-acetate 12-myristate

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to lipid [inference]

cellular response to phorbol 13-acetate 12-myristate

cellular response to alcohol [inference]

cellular response to phorbol 13-acetate 12-myristate

cellular response to oxygen-containing compound [inference]

cellular response to alcohol [inference]

cellular response to phorbol 13-acetate 12-myristate

cellular response to ketone [inference]

cellular response to phorbol 13-acetate 12-myristate

response to oxygen-containing compound [inference]

response to alcohol [inference]

cellular response to alcohol [inference]

cellular response to phorbol 13-acetate 12-myristate

response to phorbol 13-acetate 12-myristate [inference]

cellular response to phorbol 13-acetate 12-myristate

response to ketone [inference]

cellular response to ketone [inference]

cellular response to phorbol 13-acetate 12-myristate

response to phorbol 13-acetate 12-myristate [inference]

cellular response to phorbol 13-acetate 12-myristate

cellular response to oxygen-containing compound [inference]

cellular response to alcohol [inference]

cellular response to phorbol 13-acetate 12-myristate

cellular response to ketone [inference]

cellular response to phorbol 13-acetate 12-myristate

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to lipid [inference]

cellular response to phorbol 13-acetate 12-myristate

cellular response to alcohol [inference]

cellular response to phorbol 13-acetate 12-myristate

cellular response to oxygen-containing compound [inference]

cellular response to alcohol [inference]

cellular response to phorbol 13-acetate 12-myristate

cellular response to ketone [inference]

cellular response to phorbol 13-acetate 12-myristate

biological regulation [inference]

regulation of biological process [inference]

regulation of growth [inference]

regulation of cell growth [inference]

negative regulation of cell growth

negative regulation of growth [inference]

negative regulation of cell growth

regulation of locomotion [inference]

negative regulation of locomotion [inference]

negative regulation of cell motility [inference]

negative regulation of cell migration

regulation of cell motility [inference]

regulation of cell migration [inference]

negative regulation of cell migration

negative regulation of cell motility [inference]

negative regulation of cell migration

negative regulation of biological process [inference]

negative regulation of locomotion [inference]

negative regulation of cell motility [inference]

negative regulation of cell migration

negative regulation of growth [inference]

negative regulation of cell growth

negative regulation of cellular process [inference]

negative regulation of cell adhesion [inference]

negative regulation of cell-substrate adhesion [inference]

negative regulation of cell-matrix adhesion

negative regulation of cell growth

negative regulation of cell motility [inference]

negative regulation of cell migration

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

integrin-mediated signaling pathway

regulation of cell adhesion [inference]

negative regulation of cell adhesion [inference]

negative regulation of cell-substrate adhesion [inference]

negative regulation of cell-matrix adhesion

regulation of cell-substrate adhesion [inference]

regulation of cell-matrix adhesion [inference]

negative regulation of cell-matrix adhesion

negative regulation of cell-substrate adhesion [inference]

negative regulation of cell-matrix adhesion

negative regulation of cellular process [inference]

negative regulation of cell adhesion [inference]

negative regulation of cell-substrate adhesion [inference]

negative regulation of cell-matrix adhesion

negative regulation of cell growth

negative regulation of cell motility [inference]

negative regulation of cell migration

regulation of cellular component organization [inference]

regulation of cell growth [inference]

negative regulation of cell growth

regulation of cell motility [inference]

regulation of cell migration [inference]

negative regulation of cell migration

negative regulation of cell motility [inference]

negative regulation of cell migration

regulation of molecular function [inference]

negative regulation of molecular function [inference]

negative regulation of binding [inference]

negative regulation of protein binding [inference]

negative regulation of receptor binding

regulation of binding [inference]

regulation of protein binding [inference]

negative regulation of protein binding [inference]

negative regulation of receptor binding

regulation of receptor binding [inference]

negative regulation of receptor binding

negative regulation of binding [inference]

negative regulation of protein binding [inference]

negative regulation of receptor binding

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
motile cilium	IEA
plasma membrane	TAS
adherens junction	IEA
cell surface	IDA	22505472
acrosomal vesicle	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

cell junction [inference]

anchoring junction [inference]

cell-cell junction [inference]

adherens junction

cell projection [inference]

plasma membrane bounded cell projection [inference]

cilium [inference]

motile cilium

organelle [inference]

membrane-bounded organelle [inference]

cilium [inference]

motile cilium

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

secretory vesicle [inference]

secretory granule [inference]

acrosomal vesicle

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

secretory vesicle [inference]

secretory granule [inference]

acrosomal vesicle

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

secretory vesicle [inference]

secretory granule [inference]

acrosomal vesicle

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying entries **6 - 7** of 7 in total

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GO Term	Evidence Code	PMID
metalloendopeptidase activity	IBA TAS
metallopeptidase activity	IDA	12777399

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity [inference]

endopeptidase activity [inference]

metalloendopeptidase activity

metallopeptidase activity

metalloendopeptidase activity

catalytic activity, acting on a protein [inference]

peptidase activity [inference]

endopeptidase activity [inference]

metalloendopeptidase activity

metallopeptidase activity

metalloendopeptidase activity

binding [inference]

protein binding

signaling receptor binding [inference]

protein domain specific binding [inference]

SH3 domain binding

cell adhesion molecule binding [inference]

integrin binding

ion binding [inference]

cation binding [inference]

metal ion binding

protein-containing complex binding [inference]

integrin binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Disintegrin

Functional Category

M: Cell wall/membrane/envelope biogenesis
T: Signal transduction mechanisms

Displaying **all 4** entries
Gene Ontology
metal ion binding
metalloendopeptidase activity
metallopeptidase activity
proteolysis

Displaying **all 5** entries
InterPro
ADAM, cysteine-rich domain
Disintegrin domain superfamily
Disintegrin domain
Metallopeptidase, catalytic domain superfamily
Peptidase M12B, ADAM/reprolysin

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:1793	pancreatic cancer	Alliance of Genome Resources

Ortholog

Displaying entries **21 - 30** of 72 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Pan paniscus	100990273	9597_0:0003ec		PANPA02610
Papio anubis	101005782			PAPAN19447
Saimiri boliviensis boliviensis	101039203			SAIBB29073
Takifugu rubripes	101062014			TAKRU45275
Felis catus	101095312			FELCA36272
Ovis aries	101105128			SHEEP00913
Gorilla gorilla gorilla	101141804	9595_0:0005c7		GORGO18869
Octodon degus	101569826			OCTDE06884
Jaculus jaculus	101608252			JACJA18957
Mustela putorius furo	101676217			MUSPF02227

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Last updated: December 9, 2024