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TNF receptor superfamily member 18

Summary

Gene Symbol

TNFRSF18

Organism

Homo sapiens (human)

External Links

NCBI Gene

8784

PubChem

8784

Alliance of Genome Resources

HGNC:11914

Annotation

Keyword

3D-structure
Alternative splicing
Apoptosis
Cell membrane
Direct protein sequencing
Disulfide bond
Glycoprotein
Receptor
Reference proteome
Repeat
Secreted
Signal
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
A0A0R7FDM1
Q9Y5U5	Activation-inducible TNFR family receptor Glucocorticoid-induced TNFR-related protein

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
positive regulation of cell adhesion	IBA IMP	23892569
positive regulation of leukocyte migration	IMP	23892569
positive regulation of tyrosine phosphorylation of STAT protein	IMP	23892569
apoptotic process	IEA
tumor necrosis factor-mediated signaling pathway	IEA

GO Hierarchy

biological process

cellular process [inference]

signal transduction

cell surface receptor signaling pathway [inference]

cytokine-mediated signaling pathway [inference]

tumor necrosis factor-mediated signaling pathway

cell death [inference]

programmed cell death [inference]

apoptotic process

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

positive regulation of immune system process [inference]

positive regulation of leukocyte migration

regulation of leukocyte migration [inference]

positive regulation of leukocyte migration

regulation of metabolic process [inference]

positive regulation of metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of peptidyl-tyrosine phosphorylation [inference]

positive regulation of tyrosine phosphorylation of STAT protein

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of peptidyl-tyrosine phosphorylation [inference]

positive regulation of tyrosine phosphorylation of STAT protein

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of peptidyl-tyrosine phosphorylation [inference]

positive regulation of tyrosine phosphorylation of STAT protein

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of peptidyl-tyrosine phosphorylation [inference]

positive regulation of tyrosine phosphorylation of STAT protein

regulation of phosphorus metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of peptidyl-tyrosine phosphorylation [inference]

positive regulation of tyrosine phosphorylation of STAT protein

regulation of phosphate metabolic process [inference]

regulation of phosphorylation [inference]

regulation of protein phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of peptidyl-tyrosine phosphorylation [inference]

positive regulation of tyrosine phosphorylation of STAT protein

regulation of peptidyl-tyrosine phosphorylation [inference]

regulation of tyrosine phosphorylation of STAT protein [inference]

positive regulation of tyrosine phosphorylation of STAT protein

positive regulation of peptidyl-tyrosine phosphorylation [inference]

positive regulation of tyrosine phosphorylation of STAT protein

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of peptidyl-tyrosine phosphorylation [inference]

positive regulation of tyrosine phosphorylation of STAT protein

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of peptidyl-tyrosine phosphorylation [inference]

positive regulation of tyrosine phosphorylation of STAT protein

regulation of nitrogen compound metabolic process [inference]

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of peptidyl-tyrosine phosphorylation [inference]

positive regulation of tyrosine phosphorylation of STAT protein

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

regulation of protein phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of peptidyl-tyrosine phosphorylation [inference]

positive regulation of tyrosine phosphorylation of STAT protein

regulation of peptidyl-tyrosine phosphorylation [inference]

regulation of tyrosine phosphorylation of STAT protein [inference]

positive regulation of tyrosine phosphorylation of STAT protein

positive regulation of peptidyl-tyrosine phosphorylation [inference]

positive regulation of tyrosine phosphorylation of STAT protein

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of peptidyl-tyrosine phosphorylation [inference]

positive regulation of tyrosine phosphorylation of STAT protein

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of peptidyl-tyrosine phosphorylation [inference]

positive regulation of tyrosine phosphorylation of STAT protein

regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of peptidyl-tyrosine phosphorylation [inference]

positive regulation of tyrosine phosphorylation of STAT protein

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

regulation of protein phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of peptidyl-tyrosine phosphorylation [inference]

positive regulation of tyrosine phosphorylation of STAT protein

regulation of peptidyl-tyrosine phosphorylation [inference]

regulation of tyrosine phosphorylation of STAT protein [inference]

positive regulation of tyrosine phosphorylation of STAT protein

positive regulation of peptidyl-tyrosine phosphorylation [inference]

positive regulation of tyrosine phosphorylation of STAT protein

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of peptidyl-tyrosine phosphorylation [inference]

positive regulation of tyrosine phosphorylation of STAT protein

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of peptidyl-tyrosine phosphorylation [inference]

positive regulation of tyrosine phosphorylation of STAT protein

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

regulation of protein phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of peptidyl-tyrosine phosphorylation [inference]

positive regulation of tyrosine phosphorylation of STAT protein

regulation of peptidyl-tyrosine phosphorylation [inference]

regulation of tyrosine phosphorylation of STAT protein [inference]

positive regulation of tyrosine phosphorylation of STAT protein

positive regulation of peptidyl-tyrosine phosphorylation [inference]

positive regulation of tyrosine phosphorylation of STAT protein

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of peptidyl-tyrosine phosphorylation [inference]

positive regulation of tyrosine phosphorylation of STAT protein

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of peptidyl-tyrosine phosphorylation [inference]

positive regulation of tyrosine phosphorylation of STAT protein

regulation of locomotion [inference]

positive regulation of locomotion [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of leukocyte migration

regulation of cell motility [inference]

regulation of cell migration [inference]

regulation of leukocyte migration [inference]

positive regulation of leukocyte migration

positive regulation of cell migration [inference]

positive regulation of leukocyte migration

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of leukocyte migration

positive regulation of biological process [inference]

positive regulation of immune system process [inference]

positive regulation of leukocyte migration

positive regulation of metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of peptidyl-tyrosine phosphorylation [inference]

positive regulation of tyrosine phosphorylation of STAT protein

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of peptidyl-tyrosine phosphorylation [inference]

positive regulation of tyrosine phosphorylation of STAT protein

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of peptidyl-tyrosine phosphorylation [inference]

positive regulation of tyrosine phosphorylation of STAT protein

positive regulation of locomotion [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of leukocyte migration

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of peptidyl-tyrosine phosphorylation [inference]

positive regulation of tyrosine phosphorylation of STAT protein

positive regulation of cell adhesion

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of leukocyte migration

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

regulation of cellular process [inference]

signal transduction

cell surface receptor signaling pathway [inference]

cytokine-mediated signaling pathway [inference]

tumor necrosis factor-mediated signaling pathway

regulation of cell adhesion [inference]

positive regulation of cell adhesion

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of peptidyl-tyrosine phosphorylation [inference]

positive regulation of tyrosine phosphorylation of STAT protein

regulation of phosphorus metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of peptidyl-tyrosine phosphorylation [inference]

positive regulation of tyrosine phosphorylation of STAT protein

regulation of phosphate metabolic process [inference]

regulation of phosphorylation [inference]

regulation of protein phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of peptidyl-tyrosine phosphorylation [inference]

positive regulation of tyrosine phosphorylation of STAT protein

regulation of peptidyl-tyrosine phosphorylation [inference]

regulation of tyrosine phosphorylation of STAT protein [inference]

positive regulation of tyrosine phosphorylation of STAT protein

positive regulation of peptidyl-tyrosine phosphorylation [inference]

positive regulation of tyrosine phosphorylation of STAT protein

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of peptidyl-tyrosine phosphorylation [inference]

positive regulation of tyrosine phosphorylation of STAT protein

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of peptidyl-tyrosine phosphorylation [inference]

positive regulation of tyrosine phosphorylation of STAT protein

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

negative regulation of apoptotic process

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of peptidyl-tyrosine phosphorylation [inference]

positive regulation of tyrosine phosphorylation of STAT protein

positive regulation of cell adhesion

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of leukocyte migration

negative regulation of cellular process [inference]

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

regulation of cell motility [inference]

regulation of cell migration [inference]

regulation of leukocyte migration [inference]

positive regulation of leukocyte migration

positive regulation of cell migration [inference]

positive regulation of leukocyte migration

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of leukocyte migration

Displaying **all 3** entries
GO Term	Evidence Code	PMID
external side of plasma membrane	IBA
plasma membrane	TAS
extracellular region	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

extracellular region

membrane [inference]

plasma membrane

side of membrane [inference]

external side of plasma membrane

Displaying **all 2** entries
GO Term	Evidence Code	PMID
protein binding	IPI	18040044 18378892 32296183
tumor necrosis factor receptor activity	IEA

GO Hierarchy

molecular function

binding [inference]

protein binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

death receptor activity [inference]

tumor necrosis factor receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Tumor necrosis factor receptor superfamily member 18

Functional Category

G: Carbohydrate transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
positive regulation of cell adhesion
tumor necrosis factor-mediated signaling pathway

Displaying 1 entry
InterPro
TNFR/NGFR cysteine-rich region

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:11168	anogenital venereal wart	Alliance of Genome Resources
DOID:321	tropical spastic paraparesis	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 41 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Mus musculus	21936		MGI:894675	MOUSE41338
Rattus norvegicus	500598		RGD:1565872
Danio rerio	571217		ZFIN:ZDB-GENE-101104-7
Canis lupus familiaris	606971			CANLF15716
Pan troglodytes	741567	9598_0:000310		PANTR19628
Callithrix jacchus	100407686			CALJA39701
Pongo abelii	100459465	9601_0:000804		PONAB19169
Meleagris gallopavo	100542401			MELGA07551
Nomascus leucogenys	100579344			NOMLE23457
Loxodonta africana	100660206			LOXAF11523

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Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements