GlyCosmos Portal

GlyTouCan

Glycan Structure Repository

GlyComb

Glycoconjugate Repository

GlycoPOST

Glycomics MS raw data Repository

UniCarb-DR

Glycomics MS Repository for glycan annotations from GlycoWorkbench

LM-GlycoRepo

Repository for lectin-assisted multimodality data

All Resources

Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms

Other Information

Release Statistics Download

Tools

Glycan Converters

LM-GlycomeAtlas

Search Tools

Cross Search Glycan Search Publication Search Programmatic Access

Guidelines

MIRAGE

fructose-bisphosphatase 2

Summary

Gene Symbol

FBP2

Organism

Homo sapiens (human)

External Links

NCBI Gene

8789

HGNC

3607

KEGG Gene ID

hsa:8789

PubChem

8789

Alliance of Genome Resources

HGNC:3607

JoGo

FBP2

TogoVar

FBP2

Annotation

Keyword

3D-structure
Allosteric enzyme
Calcium
Carbohydrate metabolism
Cell junction
Cytoplasm
Disease variant
Gluconeogenesis
Hydrolase
Leukodystrophy
Magnesium
Metal-binding
Nucleus
Phosphoprotein
Proteomics identification
Reference proteome

Proteins

Displaying 1 entry
UniProt	Protein Name
O00757	D-fructose-1,6-bisphosphate 1-phosphohydrolase 2 Muscle FBPase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 6 in total

1

2

Next ›

Last »
GO Term	Evidence Code	PMID
sucrose biosynthetic process
fructose metabolic process	IBA
fructose 6-phosphate metabolic process	IBA
gluconeogenesis	IBA
gluconeogenesis	IEA

GO Hierarchy

biological process

metabolic process [inference]

biosynthetic process [inference]

small molecule biosynthetic process [inference]

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

gluconeogenesis

organic substance biosynthetic process [inference]

carbohydrate biosynthetic process [inference]

oligosaccharide biosynthetic process [inference]

disaccharide biosynthetic process [inference]

sucrose biosynthetic process

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

gluconeogenesis

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

organophosphate metabolic process [inference]

primary metabolic process [inference]

carbohydrate metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

fructose metabolic process

glucose metabolic process [inference]

gluconeogenesis

hexose biosynthetic process [inference]

gluconeogenesis

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

gluconeogenesis

oligosaccharide metabolic process [inference]

disaccharide metabolic process [inference]

sucrose metabolic process [inference]

sucrose biosynthetic process

disaccharide biosynthetic process [inference]

sucrose biosynthetic process

oligosaccharide biosynthetic process [inference]

disaccharide biosynthetic process [inference]

sucrose biosynthetic process

carbohydrate biosynthetic process [inference]

oligosaccharide biosynthetic process [inference]

disaccharide biosynthetic process [inference]

sucrose biosynthetic process

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

gluconeogenesis

small molecule metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

fructose metabolic process

glucose metabolic process [inference]

gluconeogenesis

hexose biosynthetic process [inference]

gluconeogenesis

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

gluconeogenesis

small molecule biosynthetic process [inference]

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

gluconeogenesis

organic substance metabolic process [inference]

carbohydrate metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

fructose metabolic process

glucose metabolic process [inference]

gluconeogenesis

hexose biosynthetic process [inference]

gluconeogenesis

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

gluconeogenesis

oligosaccharide metabolic process [inference]

disaccharide metabolic process [inference]

sucrose metabolic process [inference]

sucrose biosynthetic process

disaccharide biosynthetic process [inference]

sucrose biosynthetic process

oligosaccharide biosynthetic process [inference]

disaccharide biosynthetic process [inference]

sucrose biosynthetic process

carbohydrate biosynthetic process [inference]

oligosaccharide biosynthetic process [inference]

disaccharide biosynthetic process [inference]

sucrose biosynthetic process

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

gluconeogenesis

organophosphate metabolic process [inference]

carbohydrate derivative metabolic process [inference]

organic substance biosynthetic process [inference]

carbohydrate biosynthetic process [inference]

oligosaccharide biosynthetic process [inference]

disaccharide biosynthetic process [inference]

sucrose biosynthetic process

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

gluconeogenesis

cellular process [inference]

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

organophosphate metabolic process [inference]

Displaying entries **1 - 5** of 9 in total

1

2

Next ›

Last »
GO Term	Evidence Code	PMID
nucleus	IEA
cytoplasm	IBA
cytosol	TAS
cytosol	IDA
cytosol	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

Z disc

cell junction [inference]

anchoring junction

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

nucleus

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying **all 4** entries
GO Term	Evidence Code	PMID
protein binding	IPI	25416956 25910212 28514442 31515488 32296183 32814053 33961781
fructose 1,6-bisphosphate 1-phosphatase activity	IBA
identical protein binding	IPI	25416956 31515488 32296183
metal ion binding	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

phosphoric ester hydrolase activity [inference]

phosphatase activity [inference]

carbohydrate phosphatase activity [inference]

sugar-phosphatase activity [inference]

fructose 1,6-bisphosphate 1-phosphatase activity

binding [inference]

protein binding

identical protein binding

ion binding [inference]

cation binding [inference]

metal ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

fructose-1,6-bisphosphatase I

Functional Category

G: Carbohydrate transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 9** entries
Gene Ontology
fructose 1,6-bisphosphate 1-phosphatase activity
fructose 1,6-bisphosphate metabolic process
fructose 6-phosphate metabolic process
fructose metabolic process
gluconeogenesis
hydrolase activity
metal ion binding
phosphoric ester hydrolase activity
sucrose biosynthetic process

Displaying **all 5** entries
InterPro
Fructose-1,6-bisphosphatase class 1
Fructose-1,6-bisphosphatase, active site
Fructose-1,6-bisphosphatase
Fructose-1-6-bisphosphatase class 1, C-terminal
Fructose-1-6-bisphosphatase class I, N-terminal

KEGG BRITE Database

Orthology

K03841

Name

fructose-1,6-bisphosphatase I [EC:3.1.3.11]

References

7589895

Rhea

H₂O + β-D-fructose 1,6-bisphosphate

phosphate + β-D-fructose 6-phosphate

Enzyme

3.1.3.11

PMID

Disease

The Human Phenotype Ontology

Displaying **all 8** entries
HPO ID	HPO Term
HP:0000006	Autosomal dominant inheritance
HP:0000737	Irritability
HP:0001288	Gait disturbance
HP:0002415	Leukodystrophy
HP:0002500	Abnormal cerebral white matter morphology
HP:0003593	Infantile onset
HP:0007359	Focal-onset seizure
HP:0011968	Feeding difficulties

Displaying 1 entry
Disease ID	Disease Name
OMIM:619864	leukodystrophy, childhood-onset, remitting

PubChem Disease

MedGen Diseases

Leukodystrophy, childhood-onset, remitting

OMIM Phenotypes

LEUKODYSTROPHY, CHILDHOOD-ONSET, REMITTING; CORLK

Gene-Disease-Co-Occurrences-in-Literature (PubChem)

About Release Notes Help Feedback

Click here to visit the beta site.

International Collaboration

GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

Logo License Policies Site Map

Contact: support@glycosmos.org

GlyCosmos Portal v4.4.0

Last updated: December 8, 2025