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fucose-1-phosphate guanylyltransferase

Summary

Gene Symbol

FPGT

Aliases

GFPP

Organism

Homo sapiens (human)

External Links

NCBI Gene

8790

HGNC

3825

KEGG Gene ID

hsa:8790

PubChem

8790

Alliance of Genome Resources

HGNC:3825

Annotation

Keyword

Alternative splicing
Cytoplasm
GTP-binding
Nucleotide-binding
Nucleotidyltransferase
Proteomics identification
Reference proteome

Proteins

Displaying **all 3** entries
UniProt	Protein Name
A0A0S2Z5C6
O14772	GDP-L-fucose diphosphorylase GDP-L-fucose pyrophosphorylase
A0A0S2Z4P4

Annotation information from UniProt.

Gene Ontology (GO)

Displaying 1 entry
GO Term	Evidence Code	PMID
fucose metabolic process	TAS	9804772

GO Hierarchy

biological process

metabolic process [inference]

primary metabolic process [inference]

carbohydrate metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

fucose metabolic process

small molecule metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

fucose metabolic process

organic substance metabolic process [inference]

carbohydrate metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

fucose metabolic process

Displaying **all 2** entries
GO Term	Evidence Code	PMID
cytosol	TAS
cytoplasm	TAS	9804772

GO Hierarchy

cellular component

cellular anatomical entity [inference]

Displaying **all 3** entries
GO Term	Evidence Code	PMID
catalytic activity	TAS	9804772
GTP binding	IEA
fucose-1-phosphate guanylyltransferase activity	IDA TAS	9804772

GO Hierarchy

molecular function

catalytic activity

transferase activity [inference]

transferase activity, transferring phosphorus-containing groups [inference]

nucleotidyltransferase activity [inference]

guanylyltransferase activity [inference]

fucose-1-phosphate guanylyltransferase activity

binding [inference]

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

guanyl nucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

GTP binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

guanyl nucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

purine ribonucleoside triphosphate binding [inference]

GTP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

Gene Ontology information from NCBI Gene and UniProt.

KEGG BRITE Database

Orthology

K00976

Name

fucose-1-phosphate guanylyltransferase [EC:2.7.7.30]

References

9804772

Rhea

H⁺ + GTP + β-L-fucose 1-phosphate

diphosphate + GDP-β-L-fucose

Enzyme

2.7.7.30

PMID

18199744

Disease

Disease Ontology

Displaying **all 7** entries
DO ID	Disease Name	Source
DOID:4450	renal cell carcinoma	DisGeNET
DOID:4451	renal carcinoma	DisGeNET
DOID:4464	collecting duct carcinoma	DisGeNET
DOID:4465	papillary renal cell carcinoma	DisGeNET
DOID:4467	clear cell renal cell carcinoma	DisGeNET
DOID:4471	chromophobe renal cell carcinoma	DisGeNET
DOID:4473	sarcomatoid renal cell carcinoma	DisGeNET

Ortholog

Displaying entries **1 - 10** of 69 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Caenorhabditis elegans	4926919	WB:WBGene00044903
Callorhinchus milii	103174745		CALMI06045
Danio rerio	553792	ZFIN:ZDB-GENE-050522-489	DANRE43111
Astyanax mexicanus	103031681		ASTMX20244
Ictalurus punctatus	108266010		ICTPU30491
Electrophorus electricus	113586873		ELEEL38292
Salmo salar	100195329		SALSA48321
Salmo trutta	115158009		SALTR107537
Gadus morhua	115555292		GADMO07117
Oreochromis niloticus	100704223		ORENI42846

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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GlyCosmos Portal v4.0.0

Last updated: August 19, 2024