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succinate-CoA ligase GDP/ADP-forming subunit alpha
Summary
- Gene Symbol
-
- SUCLG1
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Acetylation
- Disease variant
- Ligase
- Mitochondrion
- Nucleotide-binding
- Primary mitochondrial disease
- Reference proteome
- Transit peptide
- Tricarboxylic acid cycle
- Proteins
| UniProt | Protein Name |
|---|---|
| P53597 |
|
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| succinyl-CoA catabolic process |
|
|
| tricarboxylic acid cycle |
GO Hierarchy
biological process
metabolic process [inference]
nitrogen compound metabolic process [inference]
catabolic process [inference]
cellular metabolic process [inference]
cellular aromatic compound metabolic process [inference]
phosphorus metabolic process [inference]
cellular nitrogen compound metabolic process [inference]
cellular catabolic process [inference]
heterocycle metabolic process [inference]
primary metabolic process [inference]
small molecule metabolic process [inference]
organic substance metabolic process [inference]
organophosphate metabolic process [inference]
organic cyclic compound metabolic process [inference]
organonitrogen compound metabolic process [inference]
cellular process [inference]
cellular metabolic process [inference]
cellular aromatic compound metabolic process [inference]
phosphorus metabolic process [inference]
cellular nitrogen compound metabolic process [inference]
cellular catabolic process [inference]
heterocycle metabolic process [inference]
| GO Term | Evidence Code | PMID |
|---|---|---|
| succinate-CoA ligase complex (GDP-forming) | ||
| succinate-CoA ligase complex (ADP-forming) | ||
| mitochondrial matrix |
|
|
| mitochondrion |
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| succinate-CoA ligase (GDP-forming) activity | ||
| protein binding | ||
| succinate-CoA ligase (ADP-forming) activity | ||
| RNA binding | ||
| nucleotide binding |
GO Hierarchy
Human Protein Atlas
Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.
Rhea
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0050336 | hypophosphatemia | |
| DOID:0050700 | cardiomyopathy | |
| DOID:0060823 | syndromic X-linked intellectual disability 94 | |
| DOID:0070329 | mitochondrial DNA depletion syndrome | |
| DOID:0080124 | mitochondrial DNA depletion syndrome 5 | |
| DOID:0080128 | mitochondrial DNA depletion syndrome 9 | |
| DOID:0080326 | familial hypertrophic cardiomyopathy | |
| DOID:10534 | stomach cancer | |
| DOID:1059 | intellectual disability | |
| DOID:11832 | visual epilepsy |
- The Human Phenotype Ontology
| HPO ID | HPO Term |
|---|---|
| HP:0000007 | Autosomal recessive inheritance |
| HP:0000047 | Hypospadias |
| HP:0000202 | Orofacial cleft |
| HP:0000252 | Microcephaly |
| HP:0000365 | Hearing impairment |
| HP:0000407 | Sensorineural hearing impairment |
| HP:0000486 | Strabismus |
| HP:0000508 | Ptosis |
| HP:0000718 | Aggressive behavior |
| HP:0000736 | Short attention span |
| Disease ID | Disease Name |
|---|---|
| OMIM:245400 |
|
| ORPHA:17 |
|
PubChem Disease
- GHR Health Conditions
- MedGen Diseases
- OMIM Phenotypes
- KEGG Diseases
LIPID MAPS Gene / Proteome Database
- LMPD ID
- LMP004255
- Gene Name
- succinate-CoA ligase, alpha subunit
Ortholog
| Species | Gene ID | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|
| 175252 | WB:WBGene00017759 | ||
| 181570 | WB:WBGene00007350 | ||
| 38447 | FB:FBgn0004888 | ||
| 42326 | FB:FBgn0038708 | ||
| 116940642 | PETMA04299 | ||
| 103181504 | CALMI22945 | ||
| 102349934 | LATCH05417 | ||
| 102690930 | LEPOC12274 | ||
| 436850 | ZFIN:ZDB-GENE-040912-101 | DANRE18348 | |
| 108260517 | ICTPU24150 |
