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Guidelines

MIRAGE

penicillin-binding protein 1A

Summary

Gene Symbol

ponA

Organism

Pseudomonas aeruginosa PAO1

External Links

NCBI Gene: 881163
KEGG Gene ID: pae:PA5045
PubChem: 881163

Annotation

Keyword

3D-structure
Antibiotic resistance
Carboxypeptidase
Cell inner membrane
Cell wall biogenesis/degradation
Glycosyltransferase
Multifunctional enzyme
Peptidoglycan synthesis
Reference proteome
Signal-anchor
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q07806

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 6 in total

1

2

Next ›

Last »
GO Term	Evidence Code	PMID
proteolysis
regulation of cell shape
peptidoglycan biosynthetic process
peptidoglycan-based cell wall biogenesis	ISS	2211517
response to antibiotic

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

aminoglycan metabolic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

peptidoglycan biosynthetic process

glycosaminoglycan metabolic process [inference]

peptidoglycan metabolic process [inference]

peptidoglycan biosynthetic process

glycosaminoglycan biosynthetic process [inference]

peptidoglycan biosynthetic process

protein metabolic process [inference]

proteolysis

organonitrogen compound biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

peptidoglycan biosynthetic process

biosynthetic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

peptidoglycan biosynthetic process

cell wall macromolecule biosynthetic process [inference]

peptidoglycan biosynthetic process

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

peptidoglycan biosynthetic process

cell wall macromolecule biosynthetic process [inference]

peptidoglycan biosynthetic process

carbohydrate derivative biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

peptidoglycan biosynthetic process

organonitrogen compound biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

peptidoglycan biosynthetic process

cellular metabolic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

peptidoglycan biosynthetic process

cell wall macromolecule biosynthetic process [inference]

peptidoglycan biosynthetic process

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

aminoglycan metabolic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

peptidoglycan biosynthetic process

glycosaminoglycan metabolic process [inference]

peptidoglycan metabolic process [inference]

peptidoglycan biosynthetic process

glycosaminoglycan biosynthetic process [inference]

peptidoglycan biosynthetic process

macromolecule biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

peptidoglycan biosynthetic process

cell wall macromolecule biosynthetic process [inference]

peptidoglycan biosynthetic process

protein metabolic process [inference]

proteolysis

carbohydrate derivative metabolic process [inference]

aminoglycan metabolic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

peptidoglycan biosynthetic process

glycosaminoglycan metabolic process [inference]

peptidoglycan metabolic process [inference]

peptidoglycan biosynthetic process

glycosaminoglycan biosynthetic process [inference]

peptidoglycan biosynthetic process

carbohydrate derivative biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

peptidoglycan biosynthetic process

organonitrogen compound metabolic process [inference]

aminoglycan metabolic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

peptidoglycan biosynthetic process

glycosaminoglycan metabolic process [inference]

peptidoglycan metabolic process [inference]

peptidoglycan biosynthetic process

glycosaminoglycan biosynthetic process [inference]

peptidoglycan biosynthetic process

protein metabolic process [inference]

proteolysis

organonitrogen compound biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

peptidoglycan biosynthetic process

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

peptidoglycan biosynthetic process

cell wall macromolecule biosynthetic process [inference]

peptidoglycan biosynthetic process

carbohydrate derivative biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

peptidoglycan biosynthetic process

organonitrogen compound biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

peptidoglycan biosynthetic process

cellular process [inference]

cellular metabolic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

peptidoglycan biosynthetic process

cell wall macromolecule biosynthetic process [inference]

peptidoglycan biosynthetic process

cell wall organization or biogenesis [inference]

cell wall biogenesis [inference]

peptidoglycan-based cell wall biogenesis

cell wall organization

cellular component organization or biogenesis [inference]

cellular component organization [inference]

external encapsulating structure organization [inference]

cell wall organization

cellular component biogenesis [inference]

cell wall biogenesis [inference]

peptidoglycan-based cell wall biogenesis

response to stimulus [inference]

response to chemical [inference]

response to antibiotic

biological regulation [inference]

regulation of biological process [inference]

regulation of developmental process [inference]

regulation of anatomical structure morphogenesis [inference]

regulation of cell morphogenesis [inference]

regulation of cell shape

regulation of biological quality [inference]

regulation of cell shape

Displaying 1 entry
GO Term	Evidence Code	PMID
plasma membrane

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

Displaying **all 4** entries
GO Term	Evidence Code	PMID
penicillin binding	IDA	9358038
peptidoglycan glycosyltransferase activity
serine-type D-Ala-D-Ala carboxypeptidase activity
glycosyltransferase activity	ISS	18838391

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

glycosyltransferase activity

hexosyltransferase activity [inference]

peptidoglycan glycosyltransferase activity

hydrolase activity [inference]

peptidase activity [inference]

serine-type peptidase activity [inference]

serine-type exopeptidase activity [inference]

serine-type carboxypeptidase activity [inference]

serine-type D-Ala-D-Ala carboxypeptidase activity

exopeptidase activity [inference]

carboxypeptidase activity [inference]

serine-type carboxypeptidase activity [inference]

serine-type D-Ala-D-Ala carboxypeptidase activity

serine-type exopeptidase activity [inference]

serine-type carboxypeptidase activity [inference]

serine-type D-Ala-D-Ala carboxypeptidase activity

serine hydrolase activity [inference]

serine-type peptidase activity [inference]

serine-type exopeptidase activity [inference]

serine-type carboxypeptidase activity [inference]

serine-type D-Ala-D-Ala carboxypeptidase activity

catalytic activity, acting on a protein [inference]

peptidase activity [inference]

serine-type peptidase activity [inference]

serine-type exopeptidase activity [inference]

serine-type carboxypeptidase activity [inference]

serine-type D-Ala-D-Ala carboxypeptidase activity

exopeptidase activity [inference]

carboxypeptidase activity [inference]

serine-type carboxypeptidase activity [inference]

serine-type D-Ala-D-Ala carboxypeptidase activity

serine-type exopeptidase activity [inference]

serine-type carboxypeptidase activity [inference]

serine-type D-Ala-D-Ala carboxypeptidase activity

binding [inference]

amide binding [inference]

penicillin binding

small molecule binding [inference]

organic acid binding [inference]

carboxylic acid binding [inference]

monocarboxylic acid binding [inference]

penicillin binding

heterocyclic compound binding [inference]

penicillin binding

ion binding [inference]

anion binding [inference]

carboxylic acid binding [inference]

monocarboxylic acid binding [inference]

penicillin binding

organic cyclic compound binding [inference]

penicillin binding

sulfur compound binding [inference]

penicillin binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Bacteria

Group Name

Penicillin-binding protein

Functional Category

K: Transcription
L: Replication, recombination and repair
M: Cell wall/membrane/envelope biogenesis
T: Signal transduction mechanisms

Displaying **all 7** entries
Gene Ontology
carboxypeptidase activity
catalytic activity
hydrolase activity
penicillin binding
peptidoglycan glycosyltransferase activity
proteolysis
response to antibiotic

Displaying **all 5** entries
InterPro
Beta-lactamase/transpeptidase-like
Glycosyl transferase, family 51
Lysozyme-like domain superfamily
Penicillin binding protein transglycosylase domain
Penicillin-binding protein, transpeptidase

KEGG BRITE Database

Orthology

K05366

Name

penicillin-binding protein 1A [EC:2.4.99.28 3.4.16.4]

References

7006606

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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GlyCosmos Portal v4.2.1

Last updated: April 7, 2025