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Guidelines

MIRAGE

penicillin-binding protein 1B

Summary

Gene Symbol

mrcB

Organism

Pseudomonas aeruginosa PAO1

External Links

NCBI Gene: 881511
KEGG Gene ID: pae:PA4700
PubChem: 881511

Annotation

Keyword

Carboxypeptidase
Cell wall biogenesis/degradation
Glycosyltransferase
Multifunctional enzyme
Peptidoglycan synthesis
Reference proteome
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q9X6W0	Murein polymerase
G3XD31	Murein polymerase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying 1 entry
GO Term	Evidence Code	PMID
peptidoglycan biosynthetic process	ISS	6389538

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

aminoglycan metabolic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

peptidoglycan biosynthetic process

glycosaminoglycan metabolic process [inference]

peptidoglycan metabolic process [inference]

peptidoglycan biosynthetic process

glycosaminoglycan biosynthetic process [inference]

peptidoglycan biosynthetic process

organonitrogen compound biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

peptidoglycan biosynthetic process

biosynthetic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

peptidoglycan biosynthetic process

cell wall macromolecule biosynthetic process [inference]

peptidoglycan biosynthetic process

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

peptidoglycan biosynthetic process

cell wall macromolecule biosynthetic process [inference]

peptidoglycan biosynthetic process

carbohydrate derivative biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

peptidoglycan biosynthetic process

organonitrogen compound biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

peptidoglycan biosynthetic process

cellular metabolic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

peptidoglycan biosynthetic process

cell wall macromolecule biosynthetic process [inference]

peptidoglycan biosynthetic process

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

aminoglycan metabolic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

peptidoglycan biosynthetic process

glycosaminoglycan metabolic process [inference]

peptidoglycan metabolic process [inference]

peptidoglycan biosynthetic process

glycosaminoglycan biosynthetic process [inference]

peptidoglycan biosynthetic process

macromolecule biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

peptidoglycan biosynthetic process

cell wall macromolecule biosynthetic process [inference]

peptidoglycan biosynthetic process

carbohydrate derivative metabolic process [inference]

aminoglycan metabolic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

peptidoglycan biosynthetic process

glycosaminoglycan metabolic process [inference]

peptidoglycan metabolic process [inference]

peptidoglycan biosynthetic process

glycosaminoglycan biosynthetic process [inference]

peptidoglycan biosynthetic process

carbohydrate derivative biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

peptidoglycan biosynthetic process

organonitrogen compound metabolic process [inference]

aminoglycan metabolic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

peptidoglycan biosynthetic process

glycosaminoglycan metabolic process [inference]

peptidoglycan metabolic process [inference]

peptidoglycan biosynthetic process

glycosaminoglycan biosynthetic process [inference]

peptidoglycan biosynthetic process

organonitrogen compound biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

peptidoglycan biosynthetic process

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

peptidoglycan biosynthetic process

cell wall macromolecule biosynthetic process [inference]

peptidoglycan biosynthetic process

carbohydrate derivative biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

peptidoglycan biosynthetic process

organonitrogen compound biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

peptidoglycan biosynthetic process

cellular process [inference]

cellular metabolic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

peptidoglycan biosynthetic process

cell wall macromolecule biosynthetic process [inference]

peptidoglycan biosynthetic process

Displaying **all 3** entries
GO Term	Evidence Code	PMID
peptidoglycan glycosyltransferase activity	ISS	6389538
serine-type D-Ala-D-Ala carboxypeptidase activity	ISS	6389538
glycosyltransferase activity	ISS	18838391

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

glycosyltransferase activity

hexosyltransferase activity [inference]

peptidoglycan glycosyltransferase activity

hydrolase activity [inference]

peptidase activity [inference]

serine-type peptidase activity [inference]

serine-type exopeptidase activity [inference]

serine-type carboxypeptidase activity [inference]

serine-type D-Ala-D-Ala carboxypeptidase activity

exopeptidase activity [inference]

carboxypeptidase activity [inference]

serine-type carboxypeptidase activity [inference]

serine-type D-Ala-D-Ala carboxypeptidase activity

serine-type exopeptidase activity [inference]

serine-type carboxypeptidase activity [inference]

serine-type D-Ala-D-Ala carboxypeptidase activity

serine hydrolase activity [inference]

serine-type peptidase activity [inference]

serine-type exopeptidase activity [inference]

serine-type carboxypeptidase activity [inference]

serine-type D-Ala-D-Ala carboxypeptidase activity

catalytic activity, acting on a protein [inference]

peptidase activity [inference]

serine-type peptidase activity [inference]

serine-type exopeptidase activity [inference]

serine-type carboxypeptidase activity [inference]

serine-type D-Ala-D-Ala carboxypeptidase activity

exopeptidase activity [inference]

carboxypeptidase activity [inference]

serine-type carboxypeptidase activity [inference]

serine-type D-Ala-D-Ala carboxypeptidase activity

serine-type exopeptidase activity [inference]

serine-type carboxypeptidase activity [inference]

serine-type D-Ala-D-Ala carboxypeptidase activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Bacteria

Group Name

Penicillin-binding protein

Functional Category

K: Transcription
L: Replication, recombination and repair
M: Cell wall/membrane/envelope biogenesis
T: Signal transduction mechanisms

Displaying **all 7** entries
Gene Ontology
carboxypeptidase activity
catalytic activity
hydrolase activity
penicillin binding
peptidoglycan glycosyltransferase activity
proteolysis
response to antibiotic

Displaying **all 5** entries
InterPro
Beta-lactamase/transpeptidase-like
Glycosyl transferase, family 51
Lysozyme-like domain superfamily
Penicillin binding protein transglycosylase domain
Penicillin-binding protein, transpeptidase

KEGG BRITE Database

Orthology

K05365

Name

penicillin-binding protein 1B [EC:2.4.99.28 3.4.16.4]

References

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GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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GlyCosmos Portal v4.2.1

Last updated: April 7, 2025