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aldehyde dehydrogenase 1 family member A2

Summary

Gene Symbol

ALDH1A2

Organism

Homo sapiens (human)

External Links

NCBI Gene

8854

PubChem

8854

Alliance of Genome Resources

HGNC:15472

Annotation

Keyword

3D-structure
Alternative splicing
Cytoplasm
Disease variant
Lipid metabolism
NAD
Oxidoreductase
Phosphoprotein
Proteomics identification
Reference proteome

Proteins

Displaying 1 entry
UniProt	Protein Name
O94788	Aldehyde dehydrogenase family 1 member A2 Retinaldehyde-specific dehydrogenase type 2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 43 in total

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GO Term	Evidence Code	PMID
blood vessel development	IEA
kidney development	IEA
liver development	IEA
retinoic acid biosynthetic process	IDA	29240402
retinoic acid biosynthetic process	IMP	33565183

GO Hierarchy

biological process

metabolic process [inference]

biosynthetic process [inference]

cellular biosynthetic process [inference]

isoprenoid biosynthetic process [inference]

terpenoid biosynthetic process [inference]

diterpenoid biosynthetic process [inference]

retinoic acid biosynthetic process

9-cis-retinoic acid biosynthetic process

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

retinoic acid biosynthetic process

9-cis-retinoic acid biosynthetic process

small molecule biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

retinoic acid biosynthetic process

9-cis-retinoic acid biosynthetic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

isoprenoid biosynthetic process [inference]

terpenoid biosynthetic process [inference]

diterpenoid biosynthetic process [inference]

retinoic acid biosynthetic process

9-cis-retinoic acid biosynthetic process

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

retinoic acid biosynthetic process

9-cis-retinoic acid biosynthetic process

hormone metabolic process [inference]

retinol metabolic process

retinoic acid metabolic process

retinoic acid biosynthetic process

9-cis-retinoic acid biosynthetic process

9-cis-retinoic acid metabolic process [inference]

9-cis-retinoic acid biosynthetic process

cellular metabolic process [inference]

cellular aldehyde metabolic process [inference]

retinal metabolic process

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

retinoic acid biosynthetic process

9-cis-retinoic acid biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

retinoic acid metabolic process

retinoic acid biosynthetic process

9-cis-retinoic acid biosynthetic process

9-cis-retinoic acid metabolic process [inference]

9-cis-retinoic acid biosynthetic process

monocarboxylic acid biosynthetic process [inference]

retinoic acid biosynthetic process

9-cis-retinoic acid biosynthetic process

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

retinoic acid biosynthetic process

9-cis-retinoic acid biosynthetic process

cellular biosynthetic process [inference]

isoprenoid biosynthetic process [inference]

terpenoid biosynthetic process [inference]

diterpenoid biosynthetic process [inference]

retinoic acid biosynthetic process

9-cis-retinoic acid biosynthetic process

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

retinoic acid biosynthetic process

9-cis-retinoic acid biosynthetic process

cellular lipid metabolic process [inference]

isoprenoid metabolic process [inference]

terpenoid metabolic process [inference]

diterpenoid metabolic process [inference]

retinoid metabolic process [inference]

retinoic acid metabolic process

retinoic acid biosynthetic process

9-cis-retinoic acid biosynthetic process

9-cis-retinoic acid metabolic process [inference]

9-cis-retinoic acid biosynthetic process

retinal metabolic process

diterpenoid biosynthetic process [inference]

retinoic acid biosynthetic process

9-cis-retinoic acid biosynthetic process

terpenoid biosynthetic process [inference]

diterpenoid biosynthetic process [inference]

retinoic acid biosynthetic process

9-cis-retinoic acid biosynthetic process

isoprenoid biosynthetic process [inference]

terpenoid biosynthetic process [inference]

diterpenoid biosynthetic process [inference]

retinoic acid biosynthetic process

9-cis-retinoic acid biosynthetic process

primary metabolic process [inference]

lipid metabolic process [inference]

lipid biosynthetic process [inference]

isoprenoid biosynthetic process [inference]

terpenoid biosynthetic process [inference]

diterpenoid biosynthetic process [inference]

retinoic acid biosynthetic process

9-cis-retinoic acid biosynthetic process

cellular lipid metabolic process [inference]

isoprenoid metabolic process [inference]

terpenoid metabolic process [inference]

diterpenoid metabolic process [inference]

retinoid metabolic process [inference]

retinoic acid metabolic process

retinoic acid biosynthetic process

9-cis-retinoic acid biosynthetic process

9-cis-retinoic acid metabolic process [inference]

9-cis-retinoic acid biosynthetic process

retinal metabolic process

diterpenoid biosynthetic process [inference]

retinoic acid biosynthetic process

9-cis-retinoic acid biosynthetic process

terpenoid biosynthetic process [inference]

diterpenoid biosynthetic process [inference]

retinoic acid biosynthetic process

9-cis-retinoic acid biosynthetic process

isoprenoid biosynthetic process [inference]

terpenoid biosynthetic process [inference]

diterpenoid biosynthetic process [inference]

retinoic acid biosynthetic process

9-cis-retinoic acid biosynthetic process

small molecule metabolic process [inference]

alcohol metabolic process [inference]

primary alcohol metabolic process [inference]

retinol metabolic process

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

retinoic acid biosynthetic process

9-cis-retinoic acid biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

retinoic acid metabolic process

retinoic acid biosynthetic process

9-cis-retinoic acid biosynthetic process

9-cis-retinoic acid metabolic process [inference]

9-cis-retinoic acid biosynthetic process

monocarboxylic acid biosynthetic process [inference]

retinoic acid biosynthetic process

9-cis-retinoic acid biosynthetic process

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

retinoic acid biosynthetic process

9-cis-retinoic acid biosynthetic process

vitamin metabolic process [inference]

fat-soluble vitamin metabolic process [inference]

vitamin A metabolic process

small molecule biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

retinoic acid biosynthetic process

9-cis-retinoic acid biosynthetic process

organic substance metabolic process [inference]

cellular aldehyde metabolic process [inference]

retinal metabolic process

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

retinoic acid biosynthetic process

9-cis-retinoic acid biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

retinoic acid metabolic process

retinoic acid biosynthetic process

9-cis-retinoic acid biosynthetic process

9-cis-retinoic acid metabolic process [inference]

9-cis-retinoic acid biosynthetic process

monocarboxylic acid biosynthetic process [inference]

retinoic acid biosynthetic process

9-cis-retinoic acid biosynthetic process

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

retinoic acid biosynthetic process

9-cis-retinoic acid biosynthetic process

lipid metabolic process [inference]

lipid biosynthetic process [inference]

isoprenoid biosynthetic process [inference]

terpenoid biosynthetic process [inference]

diterpenoid biosynthetic process [inference]

retinoic acid biosynthetic process

9-cis-retinoic acid biosynthetic process

cellular lipid metabolic process [inference]

isoprenoid metabolic process [inference]

terpenoid metabolic process [inference]

diterpenoid metabolic process [inference]

retinoid metabolic process [inference]

retinoic acid metabolic process

retinoic acid biosynthetic process

9-cis-retinoic acid biosynthetic process

9-cis-retinoic acid metabolic process [inference]

9-cis-retinoic acid biosynthetic process

retinal metabolic process

diterpenoid biosynthetic process [inference]

retinoic acid biosynthetic process

9-cis-retinoic acid biosynthetic process

terpenoid biosynthetic process [inference]

diterpenoid biosynthetic process [inference]

retinoic acid biosynthetic process

9-cis-retinoic acid biosynthetic process

isoprenoid biosynthetic process [inference]

terpenoid biosynthetic process [inference]

diterpenoid biosynthetic process [inference]

retinoic acid biosynthetic process

9-cis-retinoic acid biosynthetic process

olefinic compound metabolic process [inference]

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

isoprenoid biosynthetic process [inference]

terpenoid biosynthetic process [inference]

diterpenoid biosynthetic process [inference]

retinoic acid biosynthetic process

9-cis-retinoic acid biosynthetic process

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

retinoic acid biosynthetic process

9-cis-retinoic acid biosynthetic process

organic hydroxy compound metabolic process [inference]

alcohol metabolic process [inference]

primary alcohol metabolic process [inference]

retinol metabolic process

cellular process [inference]

signal transduction [inference]

intracellular receptor signaling pathway [inference]

retinoic acid receptor signaling pathway

cell population proliferation

cellular metabolic process [inference]

cellular aldehyde metabolic process [inference]

retinal metabolic process

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

retinoic acid biosynthetic process

9-cis-retinoic acid biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

retinoic acid metabolic process

retinoic acid biosynthetic process

9-cis-retinoic acid biosynthetic process

9-cis-retinoic acid metabolic process [inference]

9-cis-retinoic acid biosynthetic process

monocarboxylic acid biosynthetic process [inference]

retinoic acid biosynthetic process

9-cis-retinoic acid biosynthetic process

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

retinoic acid biosynthetic process

9-cis-retinoic acid biosynthetic process

cellular biosynthetic process [inference]

isoprenoid biosynthetic process [inference]

terpenoid biosynthetic process [inference]

diterpenoid biosynthetic process [inference]

retinoic acid biosynthetic process

9-cis-retinoic acid biosynthetic process

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

retinoic acid biosynthetic process

9-cis-retinoic acid biosynthetic process

cellular lipid metabolic process [inference]

isoprenoid metabolic process [inference]

terpenoid metabolic process [inference]

diterpenoid metabolic process [inference]

retinoid metabolic process [inference]

retinoic acid metabolic process

retinoic acid biosynthetic process

9-cis-retinoic acid biosynthetic process

9-cis-retinoic acid metabolic process [inference]

9-cis-retinoic acid biosynthetic process

retinal metabolic process

diterpenoid biosynthetic process [inference]

retinoic acid biosynthetic process

9-cis-retinoic acid biosynthetic process

terpenoid biosynthetic process [inference]

diterpenoid biosynthetic process [inference]

retinoic acid biosynthetic process

9-cis-retinoic acid biosynthetic process

isoprenoid biosynthetic process [inference]

terpenoid biosynthetic process [inference]

diterpenoid biosynthetic process [inference]

retinoic acid biosynthetic process

9-cis-retinoic acid biosynthetic process

cellular developmental process [inference]

cell differentiation [inference]

neuron differentiation

cell development [inference]

stem cell development [inference]

neural crest cell development

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to lipid [inference]

cellular response to retinoic acid

cellular response to oxygen-containing compound [inference]

cellular response to retinoic acid

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

protein-containing complex assembly [inference]

protein complex oligomerization [inference]

protein homooligomerization [inference]

protein homotetramerization

protein tetramerization [inference]

protein homotetramerization

protein-containing complex organization [inference]

protein-containing complex assembly [inference]

protein complex oligomerization [inference]

protein homooligomerization [inference]

protein homotetramerization

protein tetramerization [inference]

protein homotetramerization

multicellular organismal process [inference]

pattern specification process [inference]

regionalization [inference]

specification of symmetry [inference]

determination of bilateral symmetry

developmental process [inference]

anatomical structure morphogenesis [inference]

animal organ morphogenesis [inference]

heart morphogenesis

appendage morphogenesis [inference]

limb morphogenesis [inference]

embryonic limb morphogenesis [inference]

embryonic forelimb morphogenesis

forelimb morphogenesis [inference]

embryonic forelimb morphogenesis

embryonic appendage morphogenesis [inference]

embryonic limb morphogenesis [inference]

embryonic forelimb morphogenesis

embryonic morphogenesis [inference]

morphogenesis of embryonic epithelium

embryonic appendage morphogenesis [inference]

embryonic limb morphogenesis [inference]

embryonic forelimb morphogenesis

tissue morphogenesis [inference]

morphogenesis of an epithelium [inference]

morphogenesis of embryonic epithelium

developmental maturation [inference]

anatomical structure maturation [inference]

animal organ maturation [inference]

ureter maturation

anatomical structure development [inference]

blood vessel development

tissue development [inference]

epithelium development [inference]

neural tube development

muscle tissue development [inference]

striated muscle tissue development [inference]

cardiac muscle tissue development

hindbrain development

tube development [inference]

neural tube development

digestive tract development [inference]

cell development [inference]

stem cell development [inference]

neural crest cell development

animal organ development [inference]

kidney development

sensory organ development [inference]

eye development [inference]

camera-type eye development [inference]

embryonic camera-type eye development

embryonic organ development [inference]

gland development [inference]

face development

cellular developmental process [inference]

cell differentiation [inference]

neuron differentiation

cell development [inference]

stem cell development [inference]

neural crest cell development

response to stimulus [inference]

response to external stimulus [inference]

response to extracellular stimulus [inference]

response to nutrient levels [inference]

response to nutrient [inference]

response to vitamin [inference]

response to vitamin A

response to chemical [inference]

response to nutrient [inference]

response to vitamin [inference]

response to vitamin A

response to organic substance [inference]

response to organic cyclic compound [inference]

response to estradiol

response to lipid [inference]

response to estradiol

response to retinoic acid

cellular response to retinoic acid

response to vitamin A

cellular response to lipid [inference]

cellular response to retinoic acid

response to cytokine

cellular response to organic substance [inference]

cellular response to lipid [inference]

cellular response to retinoic acid

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to lipid [inference]

cellular response to retinoic acid

cellular response to oxygen-containing compound [inference]

cellular response to retinoic acid

response to oxygen-containing compound [inference]

response to estradiol

response to retinoic acid

cellular response to retinoic acid

cellular response to oxygen-containing compound [inference]

cellular response to retinoic acid

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to lipid [inference]

cellular response to retinoic acid

cellular response to oxygen-containing compound [inference]

cellular response to retinoic acid

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

positive regulation of gene expression

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

positive regulation of gene expression

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

positive regulation of gene expression

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cellular process [inference]

positive regulation of cell population proliferation

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of cell population proliferation

regulation of cellular process [inference]

signal transduction [inference]

intracellular receptor signaling pathway [inference]

retinoic acid receptor signaling pathway

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

positive regulation of gene expression

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

regulation of cell population proliferation [inference]

regulation of epithelial cell proliferation [inference]

regulation of endothelial cell proliferation [inference]

regulation of vascular endothelial cell proliferation

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

positive regulation of apoptotic process

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

positive regulation of cellular process [inference]

positive regulation of cell population proliferation

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

negative regulation of cellular process [inference]

negative regulation of cell population proliferation

regulation of biological quality [inference]

regulation of hormone levels [inference]

hormone metabolic process [inference]

retinol metabolic process

retinoic acid metabolic process

retinoic acid biosynthetic process

9-cis-retinoic acid biosynthetic process

9-cis-retinoic acid metabolic process [inference]

9-cis-retinoic acid biosynthetic process

Displaying **all 3** entries
GO Term	Evidence Code	PMID
cytoplasm	IDA	18495959
cytosol	TAS
perinuclear region of cytoplasm	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

Displaying **all 5** entries
GO Term	Evidence Code	PMID
retinal dehydrogenase activity	ISS
retinal dehydrogenase activity	IDA	29240402
3-chloroallyl aldehyde dehydrogenase activity	ISS
aldehyde dehydrogenase (NAD+) activity	IBA
retinal binding	ISS

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

oxidoreductase activity, acting on the aldehyde or oxo group of donors [inference]

oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [inference]

aldehyde dehydrogenase [NAD(P)+] activity [inference]

aldehyde dehydrogenase (NAD+) activity

binding [inference]

lipid binding [inference]

isoprenoid binding [inference]

retinoid binding [inference]

retinal binding

small molecule binding [inference]

vitamin binding [inference]

retinal binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Aldehyde

Functional Category

E: Amino acid transport and metabolism
K: Transcription
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
oxidoreductase activity

Displaying **all 6** entries
InterPro
Aldehyde dehydrogenase domain
Aldehyde dehydrogenase, C-terminal
Aldehyde dehydrogenase, N-terminal
Aldehyde dehydrogenase, cysteine active site
Aldehyde dehydrogenase, glutamic acid active site
Aldehyde/histidinol dehydrogenase

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:3827	congenital diaphragmatic hernia	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 87 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Saccharomyces cerevisiae S288C	216	SGD:S000005982
Saccharomyces cerevisiae S288C	217	SGD:S000005982
Saccharomyces cerevisiae S288C	219	SGD:S000005982
Saccharomyces cerevisiae S288C	220	SGD:S000005982
Xenopus tropicalis	8854	Xenbase:XB-GENE-1012909
Saccharomyces cerevisiae S288C	11668	SGD:S000005982
Saccharomyces cerevisiae S288C	11669	SGD:S000005982
Mus musculus	19378		MOUSE63956
Saccharomyces cerevisiae S288C	24188	SGD:S000005982
Saccharomyces cerevisiae S288C	26358	SGD:S000005982

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Acknowledgements