GlyCosmos Portal

Displaying **all 3** entries
GO Term	Evidence Code	PMID
lactosylceramide alpha-2,3-sialyltransferase activity	IBA IDA	9822625
beta-galactoside (CMP) alpha-2,3-sialyltransferase activity	TAS
sialyltransferase activity	TAS	10092602

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

glycosyltransferase activity [inference]

sialyltransferase activity

Gene Ontology information from NCBI Gene and UniProt.

Human Protein Atlas

ENSG00000115525

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

GlycoGene Database (GGDB)

GGDB ID

gg052

Gene Symbol

ST3GAL5

Reactions

Displaying 1 entry
Donor	Acceptor	Product	Reference
CMP-Neu5Ac	G84224TW	G91237TK	9822625

Displaying 1 entry
Donor	Acceptor	Product	Reference
CMP-Neu5Ac	G84224TW	G91237TK	9822625

Orthologous Gene

Displaying **all 2** entries
Species	Protein	mRNA
Rattus norvegicus	NP_112627	NM_031337
Mus musculus	NP_035505	NM_011375

KEGG BRITE Database

Orthology

K03370

Name

lactosylceramide alpha-2,3-sialyltransferase (sialyltransferase 9) [EC:2.4.3.9]

References

9875239

Reactions

Displaying 1 entry
KEGG Reaction	Enzyme	Acceptor	Product
R05937	2.4.3.9	G84224TW	G91237TK

Rhea

RHEA:18417

a β-D-Gal-(1→4)-β-D-Glc-(1↔1)-Cer(d18:1(4E)) + CMP-N-acetyl-β-neuraminate

H⁺ + a ganglioside GM3 (d18:1(4E)) + CMP

Enzyme

2.4.3.9

PMID

Disease

Disease Ontology

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DO ID	Disease Name	Source
DOID:0050841	focal hand dystonia	DisGeNET
DOID:0050886	Troyer syndrome	DisGeNET
DOID:0060245	Mast syndrome	DisGeNET
DOID:0060246	MASA syndrome	DisGeNET
DOID:0060470	salt and pepper syndrome	Glyco-Disease Genes Database Alliance of Genome Resources
DOID:0060491	SPOAN syndrome	DisGeNET
DOID:0060823	syndromic X-linked intellectual disability 94	DisGeNET
DOID:0070113	Niemann-Pick disease type C1	DisGeNET
DOID:0080067	Charcot-Marie-Tooth disease type 5	DisGeNET
DOID:0080470	developmental and epileptic encephalopathy 36	DisGeNET

The Human Phenotype Ontology

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HPO ID	HPO Term
HP:0000007	Autosomal recessive inheritance
HP:0000252	Microcephaly
HP:0000365	Hearing impairment
HP:0000572	Visual loss
HP:0000648	Optic atrophy
HP:0000737	Irritability
HP:0001034	Hypermelanotic macule
HP:0001252	Hypotonia
HP:0001263	Global developmental delay
HP:0001266	Choreoathetosis

Displaying 1 entry
Disease ID	Disease Name
OMIM:609056	GM3 synthase deficiency

PubChem Disease

GHR Health Conditions

GM3 synthase deficiency

MedGen Diseases

GM3 synthase deficiency

OMIM Phenotypes

SALT AND PEPPER DEVELOPMENTAL REGRESSION SYNDROME; SPDRS

KEGG Diseases

Amish infantile epilepsy syndrome

Gene-Disease-Co-Occurrences-in-Literature (PubChem)

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP000401
Gene Name: ST3 beta-galactoside alpha-2,3-sialyltransferase 5

Ortholog

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Latimeria chalumnae	102352419		LATCH08468
Danio rerio	394230	ZFIN:ZDB-GENE-060322-1	DANRE49091
Ictalurus punctatus	108269097		ICTPU33590
Electrophorus electricus	113584806		ELEEL34418
Salmo trutta	115205504		SALTR111690
Gadus morhua	115552722		GADMO02518
Oryzias latipes	101156587		ORYLA01383
Xenopus laevis	108697625	Xenbase:XB-GENE-17345694
Xenopus laevis	108706512	Xenbase:XB-GENE-17345695
Xenopus tropicalis	100329191	Xenbase:XB-GENE-955106

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

All Resources

Other Information

Tools

Search Tools

Summary

External Links

Annotation

GlycoGene Database (GGDB)

KEGG BRITE Database

PubChem Disease

LIPID MAPS Gene / Proteome Database

International Collaboration

Acknowledgements