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Standards Ontologies Notations
ST3 beta-galactoside alpha-2,3-sialyltransferase 5

Summary
Gene Symbol
  • ST3GAL5
Aliases
  • SIATGM3S
  • ST3GalV
  • ganglioside GM3 synthase
  • lactosylceramide alpha-2,3-sialyltransferase
Organism
Homo sapiens (human)
External Links
NCBI Gene
8869
GGDB ID
HGNC
10872
mRNA
map
  • 2p11.2
Protein
OMIM
KEGG Gene ID
hsa:8869
PubChem
8869
Alliance of Genome Resources
Annotation
Keyword
  • Alternative splicing
  • Disulfide bond
  • Epilepsy
  • Glycoprotein
  • Glycosyltransferase
  • Golgi apparatus
  • Intellectual disability
  • Lipid metabolism
  • Reference proteome
  • Signal-anchor
  • Transmembrane helix
Proteins
Displaying 1 entry
UniProt Protein Name
Q9UNP4
  • CMP-NeuAc:lactosylceramide alpha-2,3-sialyltransferase
  • GM3 synthase
  • Ganglioside GM3 synthase
  • ST3Gal V
  • Sialyltransferase 9
Annotation information from UniProt.
Gene Ontology (GO)
Displaying all 3 entries
GO Term Evidence Code PMID
glycosphingolipid biosynthetic process
protein glycosylation
ganglioside biosynthetic process
GO Hierarchy
Gene Ontology information from NCBI Gene and UniProt.
Human Protein Atlas
ENSG00000115525

soft tissue soft tissue blood blood blood blood blood blood blood blood blood blood blood blood blood blood lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node kidney kidney adrenal gland adrenal gland breast breast duodenum stomach small intestine colon rectum appendix esophagus eye eye salivary gland nasopharynx nasopharynx tongue tonsil tonsil tonsil hair skin adipose tissue adipose tissue adipose tissue spinal cord oral mucosa lung lung heart bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus liver pancreas thyroid gland parathyroid gland parathyroid gland parathyroid gland parathyroid gland parathyroid gland spleen gallbladder ductus deferens ductus deferens seminal vesicle seminal vesicle seminal vesicle seminal vesicle testis testis epididymis epididymis brain smooth muscle urinary bladder prostate bone marrow skeletal muscle skeletal muscle skeletal muscle skeletal muscle skeletal muscle thymus thymus cartilage sole of foot sole of foot soft tissue blood blood blood blood blood blood blood blood blood blood blood blood lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lactating breast lactating breast kidney kidney adrenal gland adrenal gland duodenum stomach small intestine colon rectum appendix esophagus eye eye salivary gland salivary gland salivary gland salivary gland salivary gland salivary gland nasopharynx tongue tonsil tonsil hair skin adipose tissue adipose tissue adipose tissue adipose tissue adipose tissue adipose tissue adipose tissue spinal cord oral mucosa lung lung heart bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus liver pancreas thyroid gland parathyroid gland parathyroid gland parathyroid gland parathyroid gland parathyroid gland spleen gallbladder brain skeletal muscle skeletal muscle skeletal muscle skeletal muscle skeletal muscle thymus thymus smooth muscle urinary bladder vagina ovary ovary fallopian tube fallopian tube endometrium placenta cervix cervix bone marrow cartilage sole of foot sole of foot olfactory region cerebral cortex cerebellum medulla pons midbrain pituitary gland hypothalamus amygdala thalamus choroid plexus choroid plexus corpus callosum basal ganglia substantia nigra dorsal raphe dorsal raphe dorsal raphe dorsal raphe dorsal raphe dorsal raphe caudate hippocampus retina retina

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas
GlycoGene Database (GGDB)
GGDB ID
gg052
Gene Symbol
  • ST3GAL5
Reactions
Displaying 1 entry
Donor Acceptor Product Reference
CMP-Neu5Ac
G84224TW
G91237TK
Displaying 1 entry
Donor Acceptor Product Reference
CMP-Neu5Ac
G84224TW
G91237TK
Orthologous Gene
Displaying all 2 entries
Species Protein mRNA
Rattus norvegicus NP_112627 NM_031337
Mus musculus NP_035505 NM_011375
KEGG BRITE Database
Orthology
K03370
Name
lactosylceramide alpha-2,3-sialyltransferase (sialyltransferase 9) [EC:2.4.3.9]
References
Reactions
Displaying 1 entry
KEGG Reaction Enzyme Acceptor Product
R05937
Rhea

RHEA:18417

a β-D-Gal-(1→4)-β-D-Glc-(1↔1)-Cer(d18:1(4E)) + CMP-N-acetyl-β-neuraminate
H+ + a ganglioside GM3 (d18:1(4E)) + CMP
Enzyme
PMID
Disease
Disease Ontology
Displaying entries 31 - 40 of 105 in total
DO ID Disease Name Source
DOID:0110781 hereditary spastic paraplegia 30
DOID:0110782 hereditary spastic paraplegia 31
DOID:0110783 hereditary spastic paraplegia 32
DOID:0110785 hereditary spastic paraplegia 34
DOID:0110786 hereditary spastic paraplegia 35
DOID:0110787 hereditary spastic paraplegia 36
DOID:0110788 hereditary spastic paraplegia 37
DOID:0110789 hereditary spastic paraplegia 38
DOID:0110790 hereditary spastic paraplegia 39
DOID:0110791 hereditary spastic paraplegia 3A
The Human Phenotype Ontology
Displaying entries 11 - 20 of 26 in total
HPO ID HPO Term
HP:0001336 Myoclonus
HP:0001344 Absent speech
HP:0001508 Failure to thrive
HP:0002013 Vomiting
HP:0002069 Bilateral tonic-clonic seizure
HP:0002133 Status epilepticus
HP:0002283 Global brain atrophy
HP:0002376 Developmental regression
HP:0002395 Lower limb hyperreflexia
HP:0003593 Infantile onset
Displaying 1 entry
Disease ID Disease Name
OMIM:609056
  • GM3 synthase deficiency
PubChem Disease
GHR Health Conditions
MedGen Diseases
OMIM Phenotypes
KEGG Diseases
Gene-Disease-Co-Occurrences-in-Literature (PubChem)
LIPID MAPS Gene / Proteome Database
LMPD ID
LMP000401
Gene Name
ST3 beta-galactoside alpha-2,3-sialyltransferase 5
Ortholog
Displaying entries 51 - 60 of 81 in total
Species Gene ID Alliance of Genome Resources Orthologous MAtrix
102453544 PELSI11095
100561853 ANOCA14281
103671460 URSMA00494
114041817 VOMUR29761
113901305 BOBOX20203
100951715 OTOGA04099
777948 TAKRU09708
102024023 CHILA07609
105731265 AOTNA35009
101033571 SAIBB36697
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Last updated: August 19, 2024