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cholecystokinin B receptor

Summary

Gene Symbol

CCKBR

Organism

Homo sapiens (human)

External Links

NCBI Gene

887

PubChem

887

Alliance of Genome Resources

HGNC:1571

Annotation

Keyword

3D-structure
Alternative splicing
Cell membrane
Disulfide bond
G-protein coupled receptor
Glycoprotein
Palmitate
Proteomics identification
Reference proteome
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
P32239	Cholecystokinin-2 receptor
E9PIC8	Cholecystokinin-2 receptor

Annotation information from UniProt.

Gene Ontology (GO)

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GO Term	Evidence Code	PMID
positive regulation of cell population proliferation	IDA	10913157
cholecystokinin signaling pathway	IDA	7681836
gastric acid secretion	IEA
cell surface receptor signaling pathway	NAS	10913157
pH reduction	IEA

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway

G protein-coupled receptor signaling pathway [inference]

multicellular organismal process [inference]

system process [inference]

digestive system process [inference]

gastric acid secretion

developmental process [inference]

anatomical structure development [inference]

tube development [inference]

digestive tract development

animal organ development [inference]

gland development

homeostatic process [inference]

chemical homeostasis [inference]

monoatomic ion homeostasis [inference]

monoatomic cation homeostasis [inference]

regulation of pH [inference]

pH reduction

localization [inference]

establishment of localization [inference]

transport [inference]

secretion [inference]

acid secretion [inference]

gastric acid secretion

biological regulation [inference]

regulation of pH [inference]

pH reduction

regulation of biological process [inference]

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cell population proliferation

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway

G protein-coupled receptor signaling pathway [inference]

regulation of cell population proliferation [inference]

positive regulation of cell population proliferation

positive regulation of cellular process [inference]

positive regulation of cell population proliferation

regulation of biological quality [inference]

positive regulation of cytosolic calcium ion concentration

Displaying **all 2** entries
GO Term	Evidence Code	PMID
intracellular membrane-bounded organelle	IDA
plasma membrane	IBA IDA TAS

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle

intracellular organelle [inference]

intracellular membrane-bounded organelle

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
protein binding	IPI	16963136 23597562 25416956
peptide hormone binding	IPI	7681836
cholecystokinin receptor activity	IBA IDA	7681836
gastrin receptor activity	IBA IDA	10913157 7681836
1-phosphatidylinositol-3-kinase regulator activity	TAS	10400698

GO Hierarchy

molecular function

binding [inference]

protein binding

signaling receptor binding [inference]

G protein-coupled receptor binding [inference]

neuropeptide receptor binding [inference]

cholecystokinin receptor binding [inference]

type B gastrin/cholecystokinin receptor binding

amide binding [inference]

peptide binding [inference]

peptide hormone binding

hormone binding [inference]

peptide hormone binding

molecular transducer activity [inference]

signaling receptor activity [inference]

peptide receptor activity [inference]

G protein-coupled peptide receptor activity [inference]

transmembrane signaling receptor activity [inference]

G protein-coupled receptor activity [inference]

G protein-coupled peptide receptor activity [inference]

molecular function regulator activity [inference]

enzyme regulator activity [inference]

kinase regulator activity [inference]

1-phosphatidylinositol-3-kinase regulator activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

receptor

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 2** entries
InterPro
G protein-coupled receptor, rhodopsin-like
GPCR, rhodopsin-like, 7TM

Disease

Disease Ontology

Displaying **all 5** entries
DO ID	Disease Name	Source
DOID:0060180	colitis	Alliance of Genome Resources
DOID:14115	toxic shock syndrome	Alliance of Genome Resources
DOID:1793	pancreatic cancer	Alliance of Genome Resources
DOID:3587	pancreatic ductal carcinoma	Alliance of Genome Resources
DOID:594	panic disorder	Alliance of Genome Resources

Ortholog

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Mus musculus	12426		MGI:99479	MOUSE51715
Rattus norvegicus	25706		RGD:2290	RATNO21240
Drosophila melanogaster	32864		FB:FBgn0030954
Caenorhabditis elegans	175341		WB:WBGene00021439
Bos taurus	281665			BOVIN06923
Xenopus laevis	378563		Xenbase:XB-GENE-5793825
Pan troglodytes	466414	9598_0:00305d		PANTR02176
Macaca mulatta	712939			MACMU10583
Monodelphis domestica	100030831			MONDO23568
Equus caballus	100055073			HORSE38635

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements