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Rho guanine nucleotide exchange factor 7

Summary

Gene Symbol

ARHGEF7

Organism

Homo sapiens (human)

External Links

NCBI Gene

8874

PubChem

8874

Alliance of Genome Resources

HGNC:15607

Annotation

Keyword

3D-structure
Acetylation
Alternative splicing
Cell junction
Cell projection
Coiled coil
Cytoplasm
Guanine-nucleotide releasing factor
Neurogenesis
Phosphoprotein
Proteomics identification
Reference proteome
SH3 domain

Proteins

Displaying **all 6** entries
UniProt	Protein Name
Q5W9H1
B7Z6G2
B7Z344
Q14155	Beta-Pix COOL-1 PAK-interacting exchange factor beta p85
A0A8V8TQ72
E9PDQ5

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 13 in total

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GO Term	Evidence Code	PMID
negative regulation of microtubule nucleation	IMP	27012601
lamellipodium assembly	IBA ISS
Golgi organization	IMP	25500533
ephrin receptor signaling pathway	TAS
Rho protein signal transduction	IMP	25500533

GO Hierarchy

biological process

cellular process [inference]

signal transduction

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

transmembrane receptor protein tyrosine kinase signaling pathway [inference]

ephrin receptor signaling pathway

intracellular signal transduction [inference]

small GTPase mediated signal transduction [inference]

Ras protein signal transduction [inference]

Rho protein signal transduction

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

Golgi organization

cellular component assembly [inference]

cell projection assembly [inference]

plasma membrane bounded cell projection assembly [inference]

lamellipodium assembly

cell junction assembly [inference]

cell-substrate junction assembly [inference]

focal adhesion assembly

cell projection organization [inference]

cell projection assembly [inference]

plasma membrane bounded cell projection assembly [inference]

lamellipodium assembly

plasma membrane bounded cell projection organization [inference]

lamellipodium organization [inference]

lamellipodium assembly

plasma membrane bounded cell projection assembly [inference]

lamellipodium assembly

cell junction organization [inference]

cell junction assembly [inference]

cell-substrate junction assembly [inference]

focal adhesion assembly

cell-substrate junction organization [inference]

cell-substrate junction assembly [inference]

focal adhesion assembly

developmental process [inference]

anatomical structure development [inference]

system development [inference]

nervous system development

biological regulation [inference]

regulation of biological process [inference]

regulation of locomotion [inference]

positive regulation of locomotion [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of fibroblast migration

regulation of cell motility [inference]

regulation of cell migration [inference]

regulation of fibroblast migration [inference]

positive regulation of fibroblast migration

positive regulation of cell migration [inference]

positive regulation of fibroblast migration

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of fibroblast migration

positive regulation of biological process [inference]

positive regulation of locomotion [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of fibroblast migration

positive regulation of cellular process [inference]

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

positive regulation of cell adhesion [inference]

positive regulation of cell-substrate adhesion [inference]

positive regulation of substrate adhesion-dependent cell spreading

positive regulation of cellular component organization [inference]

positive regulation of cell projection organization [inference]

positive regulation of lamellipodium organization [inference]

positive regulation of lamellipodium morphogenesis

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of fibroblast migration

positive regulation of developmental process [inference]

positive regulation of lamellipodium morphogenesis

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of cellular component organization [inference]

negative regulation of organelle organization [inference]

negative regulation of cytoskeleton organization [inference]

negative regulation of microtubule polymerization or depolymerization [inference]

negative regulation of microtubule polymerization [inference]

negative regulation of microtubule nucleation

negative regulation of protein-containing complex assembly [inference]

negative regulation of protein polymerization [inference]

negative regulation of microtubule polymerization [inference]

negative regulation of microtubule nucleation

negative regulation of supramolecular fiber organization [inference]

negative regulation of microtubule polymerization [inference]

negative regulation of microtubule nucleation

regulation of developmental process [inference]

regulation of anatomical structure morphogenesis [inference]

regulation of cell morphogenesis [inference]

regulation of lamellipodium morphogenesis [inference]

positive regulation of lamellipodium morphogenesis

positive regulation of developmental process [inference]

positive regulation of lamellipodium morphogenesis

regulation of cellular process [inference]

signal transduction

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

transmembrane receptor protein tyrosine kinase signaling pathway [inference]

ephrin receptor signaling pathway

intracellular signal transduction [inference]

small GTPase mediated signal transduction [inference]

Ras protein signal transduction [inference]

Rho protein signal transduction

regulation of cell adhesion [inference]

regulation of cell-substrate adhesion [inference]

positive regulation of cell-substrate adhesion [inference]

positive regulation of substrate adhesion-dependent cell spreading

regulation of substrate adhesion-dependent cell spreading [inference]

positive regulation of substrate adhesion-dependent cell spreading

positive regulation of cell adhesion [inference]

positive regulation of cell-substrate adhesion [inference]

positive regulation of substrate adhesion-dependent cell spreading

regulation of microtubule-based process [inference]

regulation of microtubule cytoskeleton organization [inference]

regulation of microtubule polymerization or depolymerization [inference]

negative regulation of microtubule polymerization or depolymerization [inference]

negative regulation of microtubule polymerization [inference]

negative regulation of microtubule nucleation

regulation of microtubule polymerization [inference]

regulation of microtubule nucleation [inference]

negative regulation of microtubule nucleation

negative regulation of microtubule polymerization [inference]

negative regulation of microtubule nucleation

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

positive regulation of apoptotic process

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

regulation of cellular component biogenesis [inference]

regulation of protein-containing complex assembly [inference]

negative regulation of protein-containing complex assembly [inference]

negative regulation of protein polymerization [inference]

negative regulation of microtubule polymerization [inference]

negative regulation of microtubule nucleation

regulation of protein polymerization [inference]

regulation of microtubule polymerization [inference]

regulation of microtubule nucleation [inference]

negative regulation of microtubule nucleation

negative regulation of microtubule polymerization [inference]

negative regulation of microtubule nucleation

negative regulation of protein polymerization [inference]

negative regulation of microtubule polymerization [inference]

negative regulation of microtubule nucleation

positive regulation of cellular process [inference]

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

positive regulation of cell adhesion [inference]

positive regulation of cell-substrate adhesion [inference]

positive regulation of substrate adhesion-dependent cell spreading

positive regulation of cellular component organization [inference]

positive regulation of cell projection organization [inference]

positive regulation of lamellipodium organization [inference]

positive regulation of lamellipodium morphogenesis

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of fibroblast migration

negative regulation of cellular process [inference]

negative regulation of cellular component organization [inference]

negative regulation of organelle organization [inference]

negative regulation of cytoskeleton organization [inference]

negative regulation of microtubule polymerization or depolymerization [inference]

negative regulation of microtubule polymerization [inference]

negative regulation of microtubule nucleation

negative regulation of protein-containing complex assembly [inference]

negative regulation of protein polymerization [inference]

negative regulation of microtubule polymerization [inference]

negative regulation of microtubule nucleation

negative regulation of supramolecular fiber organization [inference]

negative regulation of microtubule polymerization [inference]

negative regulation of microtubule nucleation

regulation of cellular component organization [inference]

regulation of cell projection organization [inference]

positive regulation of cell projection organization [inference]

positive regulation of lamellipodium organization [inference]

positive regulation of lamellipodium morphogenesis

regulation of plasma membrane bounded cell projection organization [inference]

regulation of lamellipodium organization [inference]

positive regulation of lamellipodium organization [inference]

positive regulation of lamellipodium morphogenesis

regulation of lamellipodium morphogenesis [inference]

positive regulation of lamellipodium morphogenesis

regulation of organelle organization [inference]

negative regulation of organelle organization [inference]

negative regulation of cytoskeleton organization [inference]

negative regulation of microtubule polymerization or depolymerization [inference]

negative regulation of microtubule polymerization [inference]

negative regulation of microtubule nucleation

regulation of cytoskeleton organization [inference]

negative regulation of cytoskeleton organization [inference]

negative regulation of microtubule polymerization or depolymerization [inference]

negative regulation of microtubule polymerization [inference]

negative regulation of microtubule nucleation

regulation of microtubule cytoskeleton organization [inference]

regulation of microtubule polymerization or depolymerization [inference]

negative regulation of microtubule polymerization or depolymerization [inference]

negative regulation of microtubule polymerization [inference]

negative regulation of microtubule nucleation

regulation of microtubule polymerization [inference]

regulation of microtubule nucleation [inference]

negative regulation of microtubule nucleation

negative regulation of microtubule polymerization [inference]

negative regulation of microtubule nucleation

regulation of protein-containing complex assembly [inference]

negative regulation of protein-containing complex assembly [inference]

negative regulation of protein polymerization [inference]

negative regulation of microtubule polymerization [inference]

negative regulation of microtubule nucleation

regulation of protein polymerization [inference]

regulation of microtubule polymerization [inference]

regulation of microtubule nucleation [inference]

negative regulation of microtubule nucleation

negative regulation of microtubule polymerization [inference]

negative regulation of microtubule nucleation

negative regulation of protein polymerization [inference]

negative regulation of microtubule polymerization [inference]

negative regulation of microtubule nucleation

negative regulation of cellular component organization [inference]

negative regulation of organelle organization [inference]

negative regulation of cytoskeleton organization [inference]

negative regulation of microtubule polymerization or depolymerization [inference]

negative regulation of microtubule polymerization [inference]

negative regulation of microtubule nucleation

negative regulation of protein-containing complex assembly [inference]

negative regulation of protein polymerization [inference]

negative regulation of microtubule polymerization [inference]

negative regulation of microtubule nucleation

negative regulation of supramolecular fiber organization [inference]

negative regulation of microtubule polymerization [inference]

negative regulation of microtubule nucleation

positive regulation of cellular component organization [inference]

positive regulation of cell projection organization [inference]

positive regulation of lamellipodium organization [inference]

positive regulation of lamellipodium morphogenesis

regulation of supramolecular fiber organization [inference]

regulation of microtubule polymerization [inference]

regulation of microtubule nucleation [inference]

negative regulation of microtubule nucleation

negative regulation of microtubule polymerization [inference]

negative regulation of microtubule nucleation

negative regulation of supramolecular fiber organization [inference]

negative regulation of microtubule polymerization [inference]

negative regulation of microtubule nucleation

regulation of cell motility [inference]

regulation of cell migration [inference]

regulation of fibroblast migration [inference]

positive regulation of fibroblast migration

positive regulation of cell migration [inference]

positive regulation of fibroblast migration

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of fibroblast migration

regulation of molecular function [inference]

positive regulation of molecular function [inference]

positive regulation of catalytic activity [inference]

positive regulation of hydrolase activity [inference]

positive regulation of GTPase activity

regulation of catalytic activity [inference]

positive regulation of catalytic activity [inference]

positive regulation of hydrolase activity [inference]

positive regulation of GTPase activity

regulation of hydrolase activity [inference]

regulation of GTPase activity [inference]

positive regulation of GTPase activity

positive regulation of hydrolase activity [inference]

positive regulation of GTPase activity

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
cell cortex	IEA
focal adhesion	HDA	21423176
postsynapse	ISS
protein-containing complex	IDA	11864573
neuronal cell body	IDA	21048939

GO Hierarchy

cellular component

protein-containing complex

cellular anatomical entity [inference]

spindle pole [inference]

mitotic spindle pole

cytoplasm

cell cortex

microtubule organizing center [inference]

centrosome

cytosol

cell junction [inference]

anchoring junction [inference]

cell-substrate junction [inference]

focal adhesion

cell projection [inference]

plasma membrane bounded cell projection [inference]

cell body [inference]

neuronal cell body

postsynapse

Displaying **all 4** entries
GO Term	Evidence Code	PMID
protein binding	IPI	11864573 15182672 16101281 16329988 16374509 16407834 16492808 16628223 16787945 16983070 19041750 19118189 19555689 20395446 20936779 21048939 21295525 21653829 23455922 24550280 24792722 25150978 25416956 25500533 26617989 27012601 29997244 31980649 32661924 32814053 33961781 35271311
guanyl-nucleotide exchange factor activity	EXP IBA IDA	12695502 17310244 21048939
protein kinase binding	IPI	21048939
gamma-tubulin binding	IDA	27012601

GO Hierarchy

molecular function

binding [inference]

protein binding

cytoskeletal protein binding [inference]

tubulin binding [inference]

gamma-tubulin binding

enzyme binding [inference]

kinase binding [inference]

protein kinase binding

molecular function regulator activity [inference]

enzyme regulator activity [inference]

nucleoside-triphosphatase regulator activity [inference]

GTPase regulator activity [inference]

guanyl-nucleotide exchange factor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Rho guanine nucleotide exchange factor

Functional Category

G: Carbohydrate transport and metabolism
J: Translation, ribosomal structure and biogenesis
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
lamellipodium assembly

Displaying **all 7** entries
InterPro
Dbl homology (DH) domain superfamily
Dbl homology (DH) domain
PH-like domain superfamily
Pleckstrin homology domain
RhoGEF 6/7, PH domain
SH3 domain
SH3-like domain superfamily

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:6713	cerebrovascular disease	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 73 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Drosophila melanogaster	35306		FB:FBgn0015803
Mus musculus	54126		MGI:1860493	MOUSE57624
Rattus norvegicus	114559		RGD:620624	RATNO11475
Xenopus laevis	444424		Xenbase:XB-GENE-17335880
Pan troglodytes	452673	9598_0:00397a		PANTR08101
Danio rerio	494081		ZFIN:ZDB-GENE-041212-49
Bos taurus	524352			BOVIN04137
Danio rerio	553493		ZFIN:ZDB-GENE-060322-11	DANRE44770
Macaca mulatta	695530			MACMU16826
Monodelphis domestica	100017126			MONDO31947

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements