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eukaryotic translation initiation factor 2B subunit delta

Summary

Gene Symbol

EIF2B4

Organism

Homo sapiens (human)

External Links

NCBI Gene

8890

PubChem

8890

Alliance of Genome Resources

HGNC:3260

Annotation

Keyword

3D-structure
Acetylation
Alternative splicing
Cytoplasm
Disease variant
Initiation factor
Leukodystrophy
Phosphoprotein
Proteomics identification
Reference proteome

Proteins

Displaying **all 6** entries
UniProt	Protein Name
E7ERK9	eIF2B GDP-GTP exchange factor subunit delta
Q71US4	eIF2B GDP-GTP exchange factor subunit delta
F8W8L6
Q9UI10	eIF2B GDP-GTP exchange factor subunit delta
Q9HBP7
B4DUP5	eIF2B GDP-GTP exchange factor subunit delta

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
translational initiation	IDA	16289705
response to glucose	ISS
T cell receptor signaling pathway	IDA	8626696
myelination	IMP	14566705
response to peptide hormone	ISS

GO Hierarchy

biological process

immune system process [inference]

activation of immune response [inference]

immune response-activating signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

antigen receptor-mediated signaling pathway [inference]

T cell receptor signaling pathway

metabolic process [inference]

cellular metabolic process [inference]

translational initiation

cytoplasmic translational initiation

cellular process [inference]

signal transduction [inference]

immune response-regulating signaling pathway [inference]

immune response-activating signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

antigen receptor-mediated signaling pathway [inference]

T cell receptor signaling pathway

immune response-regulating cell surface receptor signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

antigen receptor-mediated signaling pathway [inference]

T cell receptor signaling pathway

cell surface receptor signaling pathway [inference]

immune response-regulating cell surface receptor signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

antigen receptor-mediated signaling pathway [inference]

T cell receptor signaling pathway

ensheathment of neurons [inference]

axon ensheathment [inference]

myelination

cellular metabolic process [inference]

translational initiation

cytoplasmic translational initiation

cellular developmental process [inference]

cell development [inference]

glial cell development [inference]

oligodendrocyte development

reproductive process [inference]

developmental process involved in reproduction [inference]

ovarian follicle development

developmental process [inference]

developmental process involved in reproduction [inference]

ovarian follicle development

anatomical structure development [inference]

ovarian follicle development

cell development [inference]

glial cell development [inference]

oligodendrocyte development

cellular developmental process [inference]

cell development [inference]

glial cell development [inference]

oligodendrocyte development

response to stimulus [inference]

response to stress [inference]

response to heat

response to abiotic stimulus [inference]

response to temperature stimulus [inference]

response to heat

response to endogenous stimulus [inference]

response to hormone [inference]

response to peptide hormone

response to chemical [inference]

response to organic substance [inference]

response to hormone [inference]

response to peptide hormone

response to carbohydrate [inference]

response to monosaccharide [inference]

response to hexose [inference]

response to glucose

response to organonitrogen compound [inference]

response to peptide [inference]

response to peptide hormone

response to nitrogen compound [inference]

response to organonitrogen compound [inference]

response to peptide [inference]

response to peptide hormone

response to oxygen-containing compound [inference]

response to carbohydrate [inference]

response to monosaccharide [inference]

response to hexose [inference]

response to glucose

response to peptide [inference]

response to peptide hormone

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

positive regulation of immune system process [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

immune response-activating signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

antigen receptor-mediated signaling pathway [inference]

T cell receptor signaling pathway

regulation of immune response [inference]

immune response-regulating signaling pathway [inference]

immune response-activating signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

antigen receptor-mediated signaling pathway [inference]

T cell receptor signaling pathway

immune response-regulating cell surface receptor signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

antigen receptor-mediated signaling pathway [inference]

T cell receptor signaling pathway

positive regulation of immune response [inference]

activation of immune response [inference]

immune response-activating signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

antigen receptor-mediated signaling pathway [inference]

T cell receptor signaling pathway

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

post-transcriptional regulation of gene expression [inference]

regulation of translation

regulation of cellular metabolic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

post-transcriptional regulation of gene expression [inference]

regulation of translation

regulation of nitrogen compound metabolic process [inference]

regulation of amide metabolic process [inference]

regulation of translation

regulation of protein metabolic process [inference]

regulation of translation

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

post-transcriptional regulation of gene expression [inference]

regulation of translation

regulation of protein metabolic process [inference]

regulation of translation

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of translation

positive regulation of biological process [inference]

positive regulation of immune system process [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

immune response-activating signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

antigen receptor-mediated signaling pathway [inference]

T cell receptor signaling pathway

positive regulation of response to stimulus [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

immune response-activating signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

antigen receptor-mediated signaling pathway [inference]

T cell receptor signaling pathway

regulation of response to stimulus [inference]

positive regulation of response to stimulus [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

immune response-activating signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

antigen receptor-mediated signaling pathway [inference]

T cell receptor signaling pathway

regulation of immune response [inference]

immune response-regulating signaling pathway [inference]

immune response-activating signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

antigen receptor-mediated signaling pathway [inference]

T cell receptor signaling pathway

immune response-regulating cell surface receptor signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

antigen receptor-mediated signaling pathway [inference]

T cell receptor signaling pathway

positive regulation of immune response [inference]

activation of immune response [inference]

immune response-activating signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

antigen receptor-mediated signaling pathway [inference]

T cell receptor signaling pathway

regulation of cellular process [inference]

signal transduction [inference]

immune response-regulating signaling pathway [inference]

immune response-activating signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

antigen receptor-mediated signaling pathway [inference]

T cell receptor signaling pathway

immune response-regulating cell surface receptor signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

antigen receptor-mediated signaling pathway [inference]

T cell receptor signaling pathway

cell surface receptor signaling pathway [inference]

immune response-regulating cell surface receptor signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

antigen receptor-mediated signaling pathway [inference]

T cell receptor signaling pathway

regulation of cellular metabolic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

post-transcriptional regulation of gene expression [inference]

regulation of translation

Displaying **all 3** entries
GO Term	Evidence Code	PMID
eukaryotic translation initiation factor 2B complex	IDA	11323413 15060152 27023709
cytosol	TAS
cytoplasm	IDA	11323413

GO Hierarchy

cellular component

protein-containing complex [inference]

eukaryotic translation initiation factor 2B complex

cellular anatomical entity [inference]

Displaying **all 4** entries
GO Term	Evidence Code	PMID
protein binding	IPI	15060152 25416956 25910212 28169297 31515488 32296183 32814053 33961781
translation initiation factor binding	ISS
translation initiation factor activity	IDA	16289705
guanyl-nucleotide exchange factor activity	IDA IMP	11323413 15054402 25858979 27023709

GO Hierarchy

molecular function

binding [inference]

protein binding

translation initiation factor binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

translation regulator activity, nucleic acid binding [inference]

translation factor activity, RNA binding [inference]

translation initiation factor activity

translation regulator activity [inference]

translation regulator activity, nucleic acid binding [inference]

translation factor activity, RNA binding [inference]

translation initiation factor activity

molecular function regulator activity [inference]

enzyme regulator activity [inference]

nucleoside-triphosphatase regulator activity [inference]

GTPase regulator activity [inference]

guanyl-nucleotide exchange factor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

initiation factor

Functional Category

E: Amino acid transport and metabolism
G: Carbohydrate transport and metabolism
J: Translation, ribosomal structure and biogenesis
Q: Secondary metabolites biosynthesis, transport and catabolism

Displaying 1 entry
Gene Ontology
cellular metabolic process

Displaying **all 3** entries
InterPro
Initiation factor 2B-like, C-terminal
Initiation factor 2B-related
NagB/RpiA transferase-like

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0060868	leukoencephalopathy with vanishing white matter	Alliance of Genome Resources
DOID:0070371	leukoencephalopathy with vanishing white matter 4	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 78 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Mus musculus	13667		MGI:95300	MOUSE46375
Drosophila melanogaster	37706		FB:FBgn0034858
Rattus norvegicus	117019		RGD:620208	RATNO35614
Caenorhabditis elegans	179331		WB:WBGene00008670
Pan troglodytes	459099	9598_0:000a4b		PANTR27282
Canis lupus familiaris	475702			CANLF04985
Xenopus laevis	496301		Xenbase:XB-GENE-997734
Bos taurus	521926			BOVIN02787
Danio rerio	541548		ZFIN:ZDB-GENE-030131-955	DANRE19255
Macaca mulatta	700322			MACMU08773