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eukaryotic translation initiation factor 2 subunit beta

Summary

Gene Symbol

EIF2S2

Organism

Homo sapiens (human)

External Links

NCBI Gene

8894

PubChem

8894

Alliance of Genome Resources

HGNC:3266

Annotation

Keyword

3D-structure
Acetylation
Cytoplasm
Host-virus interaction
Initiation factor
Isopeptide bond
Phosphoprotein
Reference proteome
Ubl conjugation
Zinc-finger

Proteins

Displaying **all 2** entries
UniProt	Protein Name
P20042	Eukaryotic translation initiation factor 2 subunit beta
Q6IBR8	Eukaryotic translation initiation factor 2 subunit beta

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
translational initiation	IDA	10563826
formation of translation preinitiation complex	IBA
male gonad development	IEA
male germ cell proliferation	IEA
cytoplasmic translational initiation	IMP	31836389

GO Hierarchy

biological process

metabolic process [inference]

cellular metabolic process [inference]

translational initiation

cytoplasmic translational initiation

cellular process [inference]

cell population proliferation [inference]

germ cell proliferation [inference]

male germ cell proliferation

cellular process involved in reproduction in multicellular organism [inference]

germ cell proliferation [inference]

male germ cell proliferation

cellular metabolic process [inference]

translational initiation

cytoplasmic translational initiation

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

protein-containing complex assembly [inference]

protein-RNA complex assembly [inference]

formation of translation preinitiation complex

protein-containing complex organization [inference]

protein-containing complex assembly [inference]

protein-RNA complex assembly [inference]

formation of translation preinitiation complex

protein-RNA complex organization [inference]

protein-RNA complex assembly [inference]

formation of translation preinitiation complex

reproductive process [inference]

developmental process involved in reproduction [inference]

reproductive structure development [inference]

gonad development [inference]

male gonad development

cellular process involved in reproduction in multicellular organism [inference]

germ cell proliferation [inference]

male germ cell proliferation

multicellular organismal process [inference]

multicellular organism development [inference]

embryo development [inference]

embryo development ending in birth or egg hatching [inference]

chordate embryonic development [inference]

in utero embryonic development

developmental process [inference]

developmental process involved in reproduction [inference]

reproductive structure development [inference]

gonad development [inference]

male gonad development

anatomical structure development [inference]

multicellular organism development [inference]

embryo development [inference]

embryo development ending in birth or egg hatching [inference]

chordate embryonic development [inference]

in utero embryonic development

animal organ development [inference]

gonad development [inference]

male gonad development

reproductive structure development [inference]

gonad development [inference]

male gonad development

Displaying **all 5** entries
GO Term	Evidence Code	PMID
eukaryotic translation initiation factor 2 complex	IBA IDA IPI	23063529 31836389
nucleus	IDA	12426392
synapse	IEA
cytosol	TAS
cytoplasm	IDA	12426392

GO Hierarchy

cellular component

protein-containing complex [inference]

eukaryotic translation initiation factor 2 complex

cellular anatomical entity [inference]

cell junction [inference]

synapse

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
protein binding	IPI	11959995 16288713 16932749 21745818 22113938 22813744 25147208 25609649 28514442 32814053 33961781 35271311
translation factor activity, RNA binding	TAS	10805737 3044606
translation initiation factor binding	IBA
translation initiation factor activity	IBA IDA	16289705
metal ion binding	IEA

GO Hierarchy

molecular function

binding [inference]

protein binding

translation initiation factor binding

ion binding [inference]

cation binding [inference]

metal ion binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

RNA binding

mRNA binding

translation regulator activity, nucleic acid binding [inference]

translation factor activity, RNA binding

translation initiation factor activity

translation regulator activity [inference]

translation regulator activity, nucleic acid binding [inference]

translation factor activity, RNA binding

translation initiation factor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

translation initiation factor

Functional Category

G: Carbohydrate transport and metabolism
J: Translation, ribosomal structure and biogenesis
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
formation of cytoplasmic translation initiation complex
formation of translation preinitiation complex
translation initiation factor binding

Displaying **all 4** entries
InterPro
Translation initiation factor IF2/IF5 domain
Translation initiation factor IF2/IF5, N-terminal
Translation initiation factor IF2/IF5, zinc-binding
Translation initiation factor IF2/IF5

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:10579	leukodystrophy	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 98 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Drosophila melanogaster	39433		FB:FBgn0004926
Mus musculus	67204		MGI:1914454	MOUSE36388
Caenorhabditis elegans	172584		WB:WBGene00010560
Rattus norvegicus	296302		RGD:735192	RATNO28584
Danio rerio	324365		ZFIN:ZDB-GENE-030131-3085	DANRE39148
Xenopus tropicalis	394505		Xenbase:XB-GENE-479634
Pan troglodytes	458188	9598_0:005218		PANTR24674
Canis lupus familiaris	477197			CANLF09468
Bos taurus	520094			BOVIN05125
Macaca mulatta	708593			MACMU02123

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Annotation

OrthoDB (Group)

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Acknowledgements