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phospholipase C zeta 1

Summary

Gene Symbol

PLCZ1

Aliases

NYD-SP27
PLCzeta

Organism

Homo sapiens (human)

External Links

NCBI Gene

89869

HGNC

19218

KEGG Gene ID

hsa:89869

PubChem

89869

Alliance of Genome Resources

HGNC:19218

Annotation

Keyword

Alternative splicing
Calcium
Cytoplasm
Developmental protein
Disease variant
Fertilization
Hydrolase
Lipid degradation
Nucleus
Reference proteome
Transducer

Proteins

Displaying **all 2** entries
UniProt	Protein Name
A0A140VJR9
Q86YW0	Phosphoinositide phospholipase C-zeta-1 Phospholipase C-zeta-1 Testis-development protein NYD-SP27

Annotation information from UniProt.

Gene Ontology (GO)

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GO Term	Evidence Code	PMID
calcium ion transport	IEA
positive regulation of cytosolic calcium ion concentration	IMP	26721930 28270562
egg activation	IMP	26721930
lipid catabolic process	IEA
intracellular signal transduction	IEA

GO Hierarchy

biological process

metabolic process [inference]

catabolic process [inference]

organic substance catabolic process [inference]

lipid catabolic process

primary metabolic process [inference]

lipid metabolic process [inference]

lipid catabolic process

organic substance metabolic process [inference]

lipid metabolic process [inference]

lipid catabolic process

organic substance catabolic process [inference]

lipid catabolic process

cellular process [inference]

cell activation [inference]

egg activation

signal transduction [inference]

intracellular signal transduction

reproductive process [inference]

multicellular organismal process [inference]

cell activation [inference]

egg activation

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

metal ion transport [inference]

calcium ion transport

organic substance transport [inference]

calcium ion transport

biological regulation [inference]

regulation of biological process [inference]

regulation of cellular process [inference]

signal transduction [inference]

intracellular signal transduction

regulation of biological quality [inference]

positive regulation of cytosolic calcium ion concentration

positive regulation of cytosolic calcium ion concentration involved in egg activation

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GO Term	Evidence Code	PMID
nucleus	IDA	18322275
nucleus	IBA
nucleoplasm	IEA
nucleolus	IEA
cytosol	TAS

GO Hierarchy

cellular component

cellular anatomical entity [inference]

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

pronucleus

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

nucleolus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

pronucleus

intracellular non-membrane-bounded organelle [inference]

nucleolus

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GO Term	Evidence Code	PMID
phosphatidylinositol phospholipase C activity	NAS	26116451
phosphatidylinositol phospholipase C activity	IDA	28270562
phosphatidylinositol phospholipase C activity	IBA
calcium ion binding	IEA
phosphatidylinositol-4,5-bisphosphate binding	IDA	28270562

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

lipase activity [inference]

phospholipase activity [inference]

phospholipase C activity [inference]

phosphatidylinositol phospholipase C activity

phosphoric ester hydrolase activity [inference]

phosphoric diester hydrolase activity [inference]

phospholipase C activity [inference]

phosphatidylinositol phospholipase C activity

binding [inference]

lipid binding [inference]

phospholipid binding [inference]

phosphatidylinositol binding [inference]

phosphatidylinositol phosphate binding [inference]

phosphatidylinositol bisphosphate binding [inference]

phosphatidylinositol-4,5-bisphosphate binding

ion binding [inference]

anion binding [inference]

phosphatidylinositol-4,5-bisphosphate binding

cation binding [inference]

metal ion binding [inference]

calcium ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase 1

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 5** entries
Gene Ontology
hydrolase activity
lipid metabolic process
phosphatidylinositol phospholipase C activity
phosphatidylinositol-mediated signaling
release of sequestered calcium ion into cytosol

Displaying **all 7** entries
InterPro
C2 domain superfamily
C2 domain
EF-hand domain pair
PLC-like phosphodiesterase, TIM beta/alpha-barrel domain superfamily
Phosphatidylinositol-specific phospholipase C, X domain
Phosphoinositide phospholipase C family
Phospholipase C, phosphatidylinositol-specific, Y domain

KEGG BRITE Database

Orthology

K05861

Name

phosphatidylinositol phospholipase C, zeta [EC:3.1.4.11]

References

Rhea

RHEA:33179

H₂O + a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate)

H⁺ + a 1,2-diacyl-sn-glycerol + 1D-myo-inositol 1,4,5-trisphosphate

Enzyme

3.1.4.11

PMID

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0070174	spermatogenic failure 17	Alliance of Genome Resources

The Human Phenotype Ontology

Displaying **all 3** entries
HPO ID	HPO Term
HP:0000007	Autosomal recessive inheritance
HP:0003251	Male infertility
HP:0011462	Young adult onset

Displaying 1 entry
Disease ID	Disease Name
OMIM:617214	spermatogenic failure 17

PubChem Disease

MedGen Diseases

Spermatogenic failure 17

OMIM Phenotypes

SPERMATOGENIC FAILURE 17; SPGF17

KEGG Diseases

Spermatogenic failure

Gene-Disease-Co-Occurrences-in-Literature (PubChem)

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP001791
Gene Name: phospholipase C, zeta 1

Ortholog

Displaying entries **1 - 10** of 72 in total

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Species	Gene ID	Alliance of Genome Resources
Saccharomyces cerevisiae S288C	5330	SGD:S000006189
Saccharomyces cerevisiae S288C	5331	SGD:S000006189
Saccharomyces cerevisiae S288C	5332	SGD:S000006189
Saccharomyces cerevisiae S288C	5333	SGD:S000006189
Saccharomyces cerevisiae S288C	5334	SGD:S000006189
Saccharomyces cerevisiae S288C	5335	SGD:S000006189
Saccharomyces cerevisiae S288C	5336	SGD:S000006189
Saccharomyces cerevisiae S288C	9651	SGD:S000006189
Saccharomyces cerevisiae S288C	18797	SGD:S000006189
Saccharomyces cerevisiae S288C	18799	SGD:S000006189

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Guidelines

Summary

External Links

Annotation

OrthoDB (Group)

KEGG BRITE Database

PubChem Disease

LIPID MAPS Gene / Proteome Database

International Collaboration

Acknowledgements