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cholesterol 25-hydroxylase

Summary

Gene Symbol

CH25H

Organism

Homo sapiens (human)

External Links

NCBI Gene

9023

HGNC

1907

KEGG Gene ID

hsa:9023

PubChem

9023

Alliance of Genome Resources

HGNC:1907

Annotation

Keyword

Endoplasmic reticulum
Glycoprotein
Iron
Metal-binding
Monooxygenase
Reference proteome
Sterol biosynthesis
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
O95992	Cholesterol 25-monooxygenase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **6 - 7** of 7 in total

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GO Term	Evidence Code	PMID
B cell chemotaxis	ISS
cholesterol metabolic process	IBA IDA	33239446

GO Hierarchy

biological process

immune system process [inference]

leukocyte migration [inference]

leukocyte chemotaxis [inference]

lymphocyte chemotaxis [inference]

B cell chemotaxis

mononuclear cell migration [inference]

lymphocyte migration [inference]

lymphocyte chemotaxis [inference]

B cell chemotaxis

metabolic process [inference]

biosynthetic process [inference]

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process

organic cyclic compound biosynthetic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process

organic hydroxy compound biosynthetic process [inference]

sterol biosynthetic process

primary metabolic process [inference]

lipid metabolic process

steroid metabolic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process

sterol metabolic process [inference]

lipid biosynthetic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process

small molecule metabolic process [inference]

alcohol metabolic process [inference]

secondary alcohol metabolic process [inference]

cholesterol metabolic process

organic substance metabolic process [inference]

lipid metabolic process

steroid metabolic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process

sterol metabolic process [inference]

lipid biosynthetic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process

organic cyclic compound metabolic process [inference]

steroid metabolic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process

sterol metabolic process [inference]

organic cyclic compound biosynthetic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process

organic cyclic compound biosynthetic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process

organic hydroxy compound biosynthetic process [inference]

sterol biosynthetic process

organic hydroxy compound metabolic process [inference]

alcohol metabolic process [inference]

secondary alcohol metabolic process [inference]

cholesterol metabolic process

sterol metabolic process [inference]

organic hydroxy compound biosynthetic process [inference]

sterol biosynthetic process

cellular process [inference]

cell motility [inference]

cell migration [inference]

leukocyte migration [inference]

leukocyte chemotaxis [inference]

lymphocyte chemotaxis [inference]

B cell chemotaxis

mononuclear cell migration [inference]

lymphocyte migration [inference]

lymphocyte chemotaxis [inference]

B cell chemotaxis

cell chemotaxis [inference]

leukocyte chemotaxis [inference]

lymphocyte chemotaxis [inference]

B cell chemotaxis

locomotion [inference]

taxis [inference]

chemotaxis [inference]

cell chemotaxis [inference]

leukocyte chemotaxis [inference]

lymphocyte chemotaxis [inference]

B cell chemotaxis

response to stimulus [inference]

response to chemical [inference]

response to organic substance [inference]

response to cytokine [inference]

response to type I interferon

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

negative regulation of metabolic process [inference]

negative regulation of lipid metabolic process [inference]

negative regulation of steroid metabolic process [inference]

negative regulation of cholesterol metabolic process

negative regulation of small molecule metabolic process [inference]

negative regulation of cholesterol metabolic process

regulation of small molecule metabolic process [inference]

negative regulation of small molecule metabolic process [inference]

negative regulation of cholesterol metabolic process

regulation of cholesterol metabolic process [inference]

negative regulation of cholesterol metabolic process

regulation of primary metabolic process [inference]

regulation of lipid metabolic process [inference]

regulation of steroid metabolic process [inference]

negative regulation of steroid metabolic process [inference]

negative regulation of cholesterol metabolic process

regulation of cholesterol metabolic process [inference]

negative regulation of cholesterol metabolic process

negative regulation of lipid metabolic process [inference]

negative regulation of steroid metabolic process [inference]

negative regulation of cholesterol metabolic process

regulation of biological process involved in symbiotic interaction [inference]

modulation by symbiont of entry into host [inference]

regulation of viral entry into host cell [inference]

negative regulation of viral entry into host cell [inference]

negative regulation of fusion of virus membrane with host plasma membrane

regulation of fusion of virus membrane with host plasma membrane [inference]

negative regulation of fusion of virus membrane with host plasma membrane

negative regulation of biological process [inference]

negative regulation of metabolic process [inference]

negative regulation of lipid metabolic process [inference]

negative regulation of steroid metabolic process [inference]

negative regulation of cholesterol metabolic process

negative regulation of small molecule metabolic process [inference]

negative regulation of cholesterol metabolic process

negative regulation of cellular process [inference]

negative regulation of cellular component organization [inference]

negative regulation of fusion of virus membrane with host plasma membrane

negative regulation of viral process [inference]

negative regulation of viral life cycle [inference]

negative regulation of viral entry into host cell [inference]

negative regulation of fusion of virus membrane with host plasma membrane

regulation of viral process [inference]

negative regulation of viral process [inference]

negative regulation of viral life cycle [inference]

negative regulation of viral entry into host cell [inference]

negative regulation of fusion of virus membrane with host plasma membrane

regulation of viral life cycle [inference]

regulation of viral entry into host cell [inference]

negative regulation of viral entry into host cell [inference]

negative regulation of fusion of virus membrane with host plasma membrane

regulation of fusion of virus membrane with host plasma membrane [inference]

negative regulation of fusion of virus membrane with host plasma membrane

negative regulation of viral life cycle [inference]

negative regulation of viral entry into host cell [inference]

negative regulation of fusion of virus membrane with host plasma membrane

regulation of cellular process [inference]

negative regulation of cellular process [inference]

negative regulation of cellular component organization [inference]

negative regulation of fusion of virus membrane with host plasma membrane

regulation of cellular component organization [inference]

negative regulation of cellular component organization [inference]

negative regulation of fusion of virus membrane with host plasma membrane

regulation of fusion of virus membrane with host plasma membrane [inference]

negative regulation of fusion of virus membrane with host plasma membrane

Displaying **all 2** entries
GO Term	Evidence Code	PMID
cytosol
endoplasmic reticulum membrane	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytosol

membrane [inference]

organelle membrane [inference]

endoplasmic reticulum membrane

Displaying **all 5** entries
GO Term	Evidence Code	PMID
steroid hydroxylase activity	IBA
C-4 methylsterol oxidase activity	IBA
iron ion binding	IEA
protein binding	IPI	32296183
cholesterol 25-hydroxylase activity	IDA ISS	32944968

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

monooxygenase activity [inference]

steroid hydroxylase activity

cholesterol 25-hydroxylase activity

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen [inference]

C-4 methylsterol oxidase activity

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [inference]

cholesterol 25-hydroxylase activity

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen [inference]

C-4 methylsterol oxidase activity

binding [inference]

protein binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

iron ion binding

Gene Ontology information from NCBI Gene and UniProt.

KEGG BRITE Database

Orthology

K10223

Name

cholesterol 25-hydroxylase [EC:1.14.99.38]

References

9852097

Rhea

O₂ + cholesterol + AH₂

A + H₂O + 25-hydroxycholesterol

Enzyme

1.14.99.38

PMID

Disease

Disease Ontology

Displaying entries **21 - 30** of 61 in total

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DO ID	Disease Name	Source
DOID:10907	microcephaly	DisGeNET
DOID:11260	rabies	DisGeNET
DOID:11870	Pick's disease	DisGeNET
DOID:1240	leukemia	DisGeNET
DOID:13515	tuberous sclerosis	DisGeNET
DOID:13810	familial hypercholesterolemia	DisGeNET
DOID:14323	Marfan syndrome	DisGeNET
DOID:1443	cerebral degeneration	DisGeNET
DOID:14525	Reye syndrome	DisGeNET
DOID:1883	hepatitis C	DisGeNET

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP001605
Gene Name: cholesterol 25-hydroxylase

Ortholog

Displaying entries **21 - 30** of 72 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Crocodylus porosus	109324314		CROPO14807
Pseudonaja textilis	113442764		PSETE15237
Serinus canaria	103813932		SERCA07724
Ornithorhynchus anatinus	100078582		ORNAN17525
Macaca mulatta	694532		MACMU46413
Papio anubis	101025055		PAPAN04719
Gorilla gorilla gorilla	101125247		GORGO00379
Pan paniscus	100974384		PANPA05114
Pan troglodytes	450584		PANTR01109
Pongo abelii	100452872		PONAB01094

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: August 19, 2024