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polycystin 2 like 1, transient receptor potential cation channel

Summary

Gene Symbol

PKD2L1

Organism

Homo sapiens (human)

External Links

NCBI Gene

9033

PubChem

9033

Alliance of Genome Resources

HGNC:9011

Annotation

Keyword

3D-structure
Alternative splicing
Calcium channel
Cell membrane
Cell projection
Cilium
Coiled coil
Cytoplasmic vesicle
Disulfide bond
Glycoprotein
Metal-binding
Palmitate
Reference proteome
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q9P0L9	Polycystic kidney disease 2-like 1 protein Polycystin-2 homolog Polycystin-L Polycystin-L1
Q1L4F0

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 13 in total

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GO Term	Evidence Code	PMID
smoothened signaling pathway	ISS
inorganic cation transmembrane transport	IDA	30004384
monoatomic cation transport	ISS
calcium ion transmembrane transport	IEA
detection of mechanical stimulus	IBA

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

smoothened signaling pathway

cellular response to stimulus [inference]

cellular response to environmental stimulus [inference]

cellular response to abiotic stimulus [inference]

cellular response to pH [inference]

cellular response to acidic pH

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

protein-containing complex assembly [inference]

protein complex oligomerization [inference]

protein homooligomerization [inference]

protein homotetramerization

protein tetramerization [inference]

protein homotetramerization

protein-containing complex organization [inference]

protein-containing complex assembly [inference]

protein complex oligomerization [inference]

protein homooligomerization [inference]

protein homotetramerization

protein tetramerization [inference]

protein homotetramerization

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

sensory perception [inference]

sensory perception of chemical stimulus [inference]

sensory perception of taste [inference]

sensory perception of sour taste

response to stimulus [inference]

response to external stimulus [inference]

detection of external stimulus [inference]

detection of mechanical stimulus

response to mechanical stimulus [inference]

detection of mechanical stimulus

response to abiotic stimulus [inference]

response to pH [inference]

response to acidic pH [inference]

cellular response to acidic pH

cellular response to pH [inference]

cellular response to acidic pH

response to water

detection of abiotic stimulus [inference]

detection of mechanical stimulus

response to mechanical stimulus [inference]

detection of mechanical stimulus

cellular response to abiotic stimulus [inference]

cellular response to pH [inference]

cellular response to acidic pH

response to chemical [inference]

response to acid chemical [inference]

response to water

response to organic substance [inference]

response to water

response to inorganic substance [inference]

response to water

response to oxygen-containing compound [inference]

response to water

response to salt [inference]

response to water

detection of stimulus [inference]

detection of external stimulus [inference]

detection of mechanical stimulus

detection of abiotic stimulus [inference]

detection of mechanical stimulus

detection of chemical stimulus [inference]

detection of chemical stimulus involved in sensory perception [inference]

detection of chemical stimulus involved in sensory perception of taste

detection of chemical stimulus involved in sensory perception of sour taste

detection of stimulus involved in sensory perception [inference]

detection of chemical stimulus involved in sensory perception [inference]

detection of chemical stimulus involved in sensory perception of taste

detection of chemical stimulus involved in sensory perception of sour taste

cellular response to stimulus [inference]

cellular response to environmental stimulus [inference]

cellular response to abiotic stimulus [inference]

cellular response to pH [inference]

cellular response to acidic pH

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport

metal ion transport [inference]

potassium ion transport [inference]

potassium ion transmembrane transport

sodium ion transport [inference]

sodium ion transmembrane transport

calcium ion transport [inference]

calcium ion transmembrane transport

monoatomic cation transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport

organic substance transport [inference]

calcium ion transport [inference]

calcium ion transmembrane transport

biological regulation [inference]

regulation of biological process [inference]

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

smoothened signaling pathway

Displaying entries **11 - 12** of 12 in total

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GO Term	Evidence Code	PMID
ciliary membrane	IEA
cytosol	IDA

GO Hierarchy

cellular component

protein-containing complex [inference]

receptor complex

membrane protein complex [inference]

transmembrane transporter complex [inference]

monoatomic ion channel complex [inference]

cation channel complex [inference]

calcium channel complex

transporter complex [inference]

transmembrane transporter complex [inference]

monoatomic ion channel complex [inference]

cation channel complex [inference]

calcium channel complex

cellular anatomical entity [inference]

membrane

plasma membrane

organelle membrane [inference]

bounding membrane of organelle [inference]

ciliary membrane

plasma membrane region [inference]

cell projection membrane [inference]

ciliary membrane

cell projection [inference]

plasma membrane bounded cell projection [inference]

cilium [inference]

non-motile cilium

organelle [inference]

membrane-bounded organelle [inference]

cilium [inference]

non-motile cilium

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle

intracellular membrane-bounded organelle

endoplasmic reticulum

intracellular vesicle [inference]

cytoplasmic vesicle

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

cytoskeleton [inference]

actin cytoskeleton

intracellular organelle [inference]

intracellular membrane-bounded organelle

endoplasmic reticulum

intracellular vesicle [inference]

cytoplasmic vesicle

intracellular non-membrane-bounded organelle [inference]

cytoskeleton [inference]

actin cytoskeleton

Displaying entries **1 - 5** of 14 in total

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GO Term	Evidence Code	PMID
protein binding	IPI	12525172 20538909 24336289 25910212
monoatomic cation transmembrane transporter activity	ISS
sodium channel activity	IBA IDA	10517637
calcium channel activity	IBA IDA	24336289
identical protein binding	ISS

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

monoatomic ion transmembrane transporter activity [inference]

monoatomic ion channel activity [inference]

monoatomic cation channel activity

calcium channel activity

potassium channel activity [inference]

calcium-activated potassium channel activity

sodium channel activity

ligand-gated monoatomic cation channel activity [inference]

calcium-activated cation channel activity

calcium-activated potassium channel activity

ligand-gated monoatomic ion channel activity [inference]

ligand-gated monoatomic cation channel activity [inference]

calcium-activated cation channel activity

calcium-activated potassium channel activity

monoatomic cation transmembrane transporter activity

monoatomic cation channel activity

calcium channel activity

potassium channel activity [inference]

calcium-activated potassium channel activity

sodium channel activity

ligand-gated monoatomic cation channel activity [inference]

calcium-activated cation channel activity

calcium-activated potassium channel activity

metal ion transmembrane transporter activity [inference]

potassium ion transmembrane transporter activity [inference]

potassium channel activity [inference]

calcium-activated potassium channel activity

sodium ion transmembrane transporter activity [inference]

sodium channel activity

calcium ion transmembrane transporter activity [inference]

calcium channel activity

inorganic molecular entity transmembrane transporter activity [inference]

inorganic cation transmembrane transporter activity [inference]

metal ion transmembrane transporter activity [inference]

potassium ion transmembrane transporter activity [inference]

potassium channel activity [inference]

calcium-activated potassium channel activity

sodium ion transmembrane transporter activity [inference]

sodium channel activity

calcium ion transmembrane transporter activity [inference]

calcium channel activity

passive transmembrane transporter activity [inference]

channel activity [inference]

monoatomic ion channel activity [inference]

monoatomic cation channel activity

calcium channel activity

potassium channel activity [inference]

calcium-activated potassium channel activity

sodium channel activity

ligand-gated monoatomic cation channel activity [inference]

calcium-activated cation channel activity

calcium-activated potassium channel activity

ligand-gated monoatomic ion channel activity [inference]

ligand-gated monoatomic cation channel activity [inference]

calcium-activated cation channel activity

calcium-activated potassium channel activity

gated channel activity [inference]

ligand-gated channel activity [inference]

ligand-gated monoatomic ion channel activity [inference]

ligand-gated monoatomic cation channel activity [inference]

calcium-activated cation channel activity

calcium-activated potassium channel activity

monoatomic ion-gated channel activity [inference]

calcium-activated cation channel activity

calcium-activated potassium channel activity

salt transmembrane transporter activity [inference]

potassium ion transmembrane transporter activity [inference]

potassium channel activity [inference]

calcium-activated potassium channel activity

sodium ion transmembrane transporter activity [inference]

sodium channel activity

calcium ion transmembrane transporter activity [inference]

calcium channel activity

binding [inference]

protein binding

cytoskeletal protein binding

actinin binding [inference]

alpha-actinin binding

muscle alpha-actinin binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

calcium ion binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

taste receptor activity [inference]

sour taste receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Polycystic kidney disease

Functional Category

E: Amino acid transport and metabolism
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
calcium channel activity
calcium ion binding
detection of mechanical stimulus

Displaying **all 3** entries
InterPro
Polycystic kidney disease type 2 protein
Polycystin cation channel, PKD1/PKD2
Polycystin domain

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0110859	polycystic kidney disease 2	Alliance of Genome Resources
DOID:898	autosomal dominant polycystic kidney disease	Alliance of Genome Resources

Ortholog

Displaying entries **61 - 70** of 75 in total

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Species	Gene ID	Orthologous MAtrix
Seriola dumerili	111220770	SERDU12226
Amphiprion ocellaris	111573114	AMPOC03813
Vulpes vulpes	112914838	VULVU00767
Astatotilapia calliptera	113035042	ASTCA06938
Bos indicus x Bos taurus	113884543	BOBOX21031
Podarcis muralis	114596998	PODMU35923
Salmo trutta	115194012	SALTR90100
Gadus morhua	115560110	GADMO14738
Sparus aurata	115596325	SPAAU09595
Strigops habroptila	115608965	STRHB04339