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NFS1 cysteine desulfurase

Summary

Gene Symbol

NFS1

Organism

Homo sapiens (human)

External Links

NCBI Gene

9054

PubChem

9054

Alliance of Genome Resources

HGNC:15910

JoGo

NFS1

TogoVar

NFS1

Annotation

Keyword

3D-structure
Alternative initiation
Alternative splicing
Cytoskeleton
Disease variant
Iron-sulfur
Mitochondrion
Molybdenum cofactor biosynthesis
Nucleus
Primary mitochondrial disease
Proteomics identification
Pyridoxal phosphate
Reference proteome
Transferase
Transit peptide

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q53FP3
Q9Y697

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **6 - 9** of 9 in total

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GO Term	Evidence Code	PMID
molybdopterin cofactor metabolic process	IDA	18650437
[2Fe-2S] cluster assembly	IDA	24971490 31664822
[4Fe-4S] cluster assembly	IDA	16527810
[4Fe-4S] cluster assembly	IEA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

metal incorporation into metallo-sulfur cluster [inference]

iron incorporation into metallo-sulfur cluster

molybdopterin cofactor metabolic process

Mo-molybdopterin cofactor metabolic process [inference]

Mo-molybdopterin cofactor biosynthetic process

molybdopterin cofactor biosynthetic process [inference]

Mo-molybdopterin cofactor biosynthetic process

organonitrogen compound biosynthetic process [inference]

molybdopterin cofactor biosynthetic process [inference]

Mo-molybdopterin cofactor biosynthetic process

biosynthetic process [inference]

cellular biosynthetic process [inference]

heterocycle biosynthetic process [inference]

molybdopterin cofactor biosynthetic process [inference]

Mo-molybdopterin cofactor biosynthetic process

organic substance biosynthetic process [inference]

organophosphate biosynthetic process [inference]

molybdopterin cofactor biosynthetic process [inference]

Mo-molybdopterin cofactor biosynthetic process

organic cyclic compound biosynthetic process [inference]

molybdopterin cofactor biosynthetic process [inference]

Mo-molybdopterin cofactor biosynthetic process

organonitrogen compound biosynthetic process [inference]

molybdopterin cofactor biosynthetic process [inference]

Mo-molybdopterin cofactor biosynthetic process

cellular metabolic process [inference]

sulfur compound metabolic process [inference]

iron-sulfur cluster assembly

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

molybdopterin cofactor metabolic process

Mo-molybdopterin cofactor metabolic process [inference]

Mo-molybdopterin cofactor biosynthetic process

molybdopterin cofactor biosynthetic process [inference]

Mo-molybdopterin cofactor biosynthetic process

organophosphate metabolic process [inference]

molybdopterin cofactor metabolic process

Mo-molybdopterin cofactor metabolic process [inference]

Mo-molybdopterin cofactor biosynthetic process

molybdopterin cofactor biosynthetic process [inference]

Mo-molybdopterin cofactor biosynthetic process

organophosphate biosynthetic process [inference]

molybdopterin cofactor biosynthetic process [inference]

Mo-molybdopterin cofactor biosynthetic process

cellular biosynthetic process [inference]

heterocycle biosynthetic process [inference]

molybdopterin cofactor biosynthetic process [inference]

Mo-molybdopterin cofactor biosynthetic process

heterocycle metabolic process [inference]

heterocycle biosynthetic process [inference]

molybdopterin cofactor biosynthetic process [inference]

Mo-molybdopterin cofactor biosynthetic process

molybdopterin cofactor metabolic process

Mo-molybdopterin cofactor metabolic process [inference]

Mo-molybdopterin cofactor biosynthetic process

molybdopterin cofactor biosynthetic process [inference]

Mo-molybdopterin cofactor biosynthetic process

primary metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

metal incorporation into metallo-sulfur cluster [inference]

iron incorporation into metallo-sulfur cluster

prosthetic group metabolic process [inference]

molybdopterin cofactor metabolic process

Mo-molybdopterin cofactor metabolic process [inference]

Mo-molybdopterin cofactor biosynthetic process

molybdopterin cofactor biosynthetic process [inference]

Mo-molybdopterin cofactor biosynthetic process

organic substance metabolic process [inference]

organophosphate metabolic process [inference]

molybdopterin cofactor metabolic process

Mo-molybdopterin cofactor metabolic process [inference]

Mo-molybdopterin cofactor biosynthetic process

molybdopterin cofactor biosynthetic process [inference]

Mo-molybdopterin cofactor biosynthetic process

organophosphate biosynthetic process [inference]

molybdopterin cofactor biosynthetic process [inference]

Mo-molybdopterin cofactor biosynthetic process

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

metal incorporation into metallo-sulfur cluster [inference]

iron incorporation into metallo-sulfur cluster

macromolecule modification [inference]

protein modification process [inference]

metal incorporation into metallo-sulfur cluster [inference]

iron incorporation into metallo-sulfur cluster

organic cyclic compound metabolic process [inference]

molybdopterin cofactor metabolic process

Mo-molybdopterin cofactor metabolic process [inference]

Mo-molybdopterin cofactor biosynthetic process

molybdopterin cofactor biosynthetic process [inference]

Mo-molybdopterin cofactor biosynthetic process

organic cyclic compound biosynthetic process [inference]

molybdopterin cofactor biosynthetic process [inference]

Mo-molybdopterin cofactor biosynthetic process

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

metal incorporation into metallo-sulfur cluster [inference]

iron incorporation into metallo-sulfur cluster

molybdopterin cofactor metabolic process

Mo-molybdopterin cofactor metabolic process [inference]

Mo-molybdopterin cofactor biosynthetic process

molybdopterin cofactor biosynthetic process [inference]

Mo-molybdopterin cofactor biosynthetic process

organonitrogen compound biosynthetic process [inference]

molybdopterin cofactor biosynthetic process [inference]

Mo-molybdopterin cofactor biosynthetic process

organic substance biosynthetic process [inference]

organophosphate biosynthetic process [inference]

molybdopterin cofactor biosynthetic process [inference]

Mo-molybdopterin cofactor biosynthetic process

organic cyclic compound biosynthetic process [inference]

molybdopterin cofactor biosynthetic process [inference]

Mo-molybdopterin cofactor biosynthetic process

organonitrogen compound biosynthetic process [inference]

molybdopterin cofactor biosynthetic process [inference]

Mo-molybdopterin cofactor biosynthetic process

cellular process [inference]

cellular metabolic process [inference]

sulfur compound metabolic process [inference]

iron-sulfur cluster assembly

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

molybdopterin cofactor metabolic process

Mo-molybdopterin cofactor metabolic process [inference]

Mo-molybdopterin cofactor biosynthetic process

molybdopterin cofactor biosynthetic process [inference]

Mo-molybdopterin cofactor biosynthetic process

organophosphate metabolic process [inference]

molybdopterin cofactor metabolic process

Mo-molybdopterin cofactor metabolic process [inference]

Mo-molybdopterin cofactor biosynthetic process

molybdopterin cofactor biosynthetic process [inference]

Mo-molybdopterin cofactor biosynthetic process

organophosphate biosynthetic process [inference]

molybdopterin cofactor biosynthetic process [inference]

Mo-molybdopterin cofactor biosynthetic process

cellular biosynthetic process [inference]

heterocycle biosynthetic process [inference]

molybdopterin cofactor biosynthetic process [inference]

Mo-molybdopterin cofactor biosynthetic process

heterocycle metabolic process [inference]

heterocycle biosynthetic process [inference]

molybdopterin cofactor biosynthetic process [inference]

Mo-molybdopterin cofactor biosynthetic process

molybdopterin cofactor metabolic process

Mo-molybdopterin cofactor metabolic process [inference]

Mo-molybdopterin cofactor biosynthetic process

molybdopterin cofactor biosynthetic process [inference]

Mo-molybdopterin cofactor biosynthetic process

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

metallo-sulfur cluster assembly [inference]

iron-sulfur cluster assembly

Displaying entries **1 - 5** of 16 in total

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GO Term	Evidence Code	PMID
nucleus	IDA	16847322 23593335
nucleus	IBA
nucleoplasm	IDA
cytoplasm	IDA	23593335
mitochondrion	NAS	27519411

GO Hierarchy

cellular component

protein-containing complex [inference]

mitochondrial protein-containing complex [inference]

mitochondrial iron-sulfur cluster assembly complex

iron-sulfur cluster assembly complex

cellular anatomical entity [inference]

microtubule organizing center [inference]

centrosome

cytosol

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

mitochondrial matrix

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
protein binding	IPI	11060020 16527810 18650437 23593335 23940031 26342079 26702583 27499296 28001042 29097656 29309586 31101807 31664822 33961781
pyridoxal phosphate binding	IEA
cysteine desulfurase activity	EXP	20873749
cysteine desulfurase activity	IDA	16527810 18650437 23593335 29097656 31101807 31664822
cysteine desulfurase activity	IBA