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protein regulator of cytokinesis 1

Summary

Gene Symbol

PRC1

Organism

Homo sapiens (human)

External Links

NCBI Gene

9055

PubChem

9055

Alliance of Genome Resources

HGNC:9341

Annotation

Keyword

3D-structure
Alternative splicing
Cell division
Chromosome
Coiled coil
Cytoskeleton
Microtubule
Nucleus
Oncogene
Phosphoprotein
Reference proteome

Proteins

Displaying 1 entry
UniProt	Protein Name
O43663

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
mitotic spindle elongation	TAS	9885575
microtubule cytoskeleton organization	IBA
positive regulation of cell population proliferation	IMP	17409436
regulation of cytokinesis	IDA	17351640
mitotic spindle midzone assembly	IBA

GO Hierarchy

biological process

cellular process [inference]

microtubule-based process [inference]

microtubule cytoskeleton organization

spindle elongation [inference]

mitotic spindle elongation

spindle midzone assembly [inference]

mitotic spindle midzone assembly

cell cycle process [inference]

spindle elongation [inference]

mitotic spindle elongation

spindle midzone assembly [inference]

mitotic spindle midzone assembly

mitotic cell cycle process [inference]

cell division

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

cytoskeleton organization [inference]

microtubule cytoskeleton organization

cellular component assembly [inference]

spindle midzone assembly [inference]

mitotic spindle midzone assembly

biological regulation [inference]

regulation of biological process [inference]

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cell population proliferation

regulation of cellular process [inference]

regulation of cell population proliferation [inference]

positive regulation of cell population proliferation

positive regulation of cellular process [inference]

positive regulation of cell population proliferation

regulation of cell division [inference]

regulation of cytokinesis

regulation of cell cycle [inference]

regulation of cell cycle process [inference]

regulation of cytokinesis

Displaying entries **1 - 5** of 15 in total

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GO Term	Evidence Code	PMID
spindle pole	IEA
nucleus	IDA	17409436
nucleoplasm	IDA
chromosome	IEA
cytoplasm	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

midbody

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

cytoskeleton [inference]

microtubule cytoskeleton

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular non-membrane-bounded organelle [inference]

cytoskeleton [inference]

microtubule cytoskeleton

intercellular bridge

spindle midzone [inference]

mitotic spindle midzone

contractile ring

supramolecular complex [inference]

supramolecular polymer [inference]

supramolecular fiber [inference]

polymeric cytoskeletal fiber [inference]

microtubule [inference]

spindle microtubule

Displaying **all 5** entries
GO Term	Evidence Code	PMID
protein binding	IPI	14744859 16189514 16431929 17409436 19447967 19468300 23036704 28514442 32296183 33961781 35849559
microtubule binding	IBA
kinesin binding	IPI	16431929
protein kinase binding	IPI	17351640
identical protein binding	IPI	16603632 20691902 23870126

GO Hierarchy

molecular function

binding [inference]

protein binding

cytoskeletal protein binding [inference]

tubulin binding [inference]

microtubule binding

kinesin binding

enzyme binding [inference]

kinase binding [inference]

protein kinase binding

identical protein binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

microtubule associated

Functional Category

E: Amino acid transport and metabolism
K: Transcription
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
microtubule binding
microtubule cytoskeleton organization
mitotic spindle midzone assembly

Displaying 1 entry
InterPro
Microtubule-associated protein, MAP65/Ase1/PRC1

Ortholog

Displaying entries **1 - 10** of 74 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	9055	Xenbase:XB-GENE-963901
Mus musculus	233406		MOUSE54183
Rattus norvegicus	308761		RATNO18176
Danio rerio	393203		DANRE40138
Pan troglodytes	453656		PANTR11182
Canis lupus familiaris	488742		CANLF12072
Macaca mulatta	704144		MACMU42150
Macaca mulatta	710182		MACMU42150
Bos taurus	767818		BOVIN16418
Monodelphis domestica	100012273		MONDO04898