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Guidelines

MIRAGE

mitogen-activated protein kinase kinase kinase 6

Summary

Gene Symbol

MAP3K6

Organism

Homo sapiens (human)

External Links

NCBI Gene

9064

PubChem

9064

Alliance of Genome Resources

HGNC:6858

JoGo

MAP3K6

TogoVar

MAP3K6

Annotation

Keyword

ATP-binding
Alternative splicing
Coiled coil
Magnesium
Metal-binding
Phosphoprotein
Proteomics identification
Reference proteome
Serine/threonine-protein kinase

Proteins

Displaying 1 entry
UniProt	Protein Name
O95382	Apoptosis signal-regulating kinase 2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 4** entries
GO Term	Evidence Code	PMID
protein phosphorylation	IDA	9875215
signal transduction	TAS	9875215
JNK cascade	IBA
p38MAPK cascade	IBA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phosphorylation [inference]

protein phosphorylation

primary metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation

macromolecule modification [inference]

protein modification process [inference]

protein phosphorylation

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation

cellular process [inference]

signal transduction

intracellular signal transduction [inference]

MAPK cascade [inference]

stress-activated MAPK cascade [inference]

stress-activated protein kinase signaling cascade [inference]

stress-activated MAPK cascade [inference]

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phosphorylation [inference]

protein phosphorylation

cellular response to stimulus [inference]

cellular response to stress [inference]

stress-activated protein kinase signaling cascade [inference]

stress-activated MAPK cascade [inference]

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

stress-activated protein kinase signaling cascade [inference]

stress-activated MAPK cascade [inference]

cellular response to stimulus [inference]

cellular response to stress [inference]

stress-activated protein kinase signaling cascade [inference]

stress-activated MAPK cascade [inference]

biological regulation [inference]

regulation of biological process [inference]

regulation of cellular process [inference]

signal transduction

intracellular signal transduction [inference]

MAPK cascade [inference]

stress-activated MAPK cascade [inference]

stress-activated protein kinase signaling cascade [inference]

stress-activated MAPK cascade [inference]

Displaying entries **1 - 5** of 7 in total

1

2

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Last »
GO Term	Evidence Code	PMID
magnesium ion binding	IDA	9875215
JUN kinase kinase kinase activity	IEA
MAP kinase kinase kinase activity	IDA	9875215
MAP kinase kinase kinase activity	IBA
protein binding	IPI	19935702 28514442 32707033 33961781 36931259

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring phosphorus-containing groups [inference]

kinase activity [inference]

protein kinase activity [inference]

protein serine/threonine kinase activity [inference]

MAP kinase kinase kinase activity

JUN kinase kinase kinase activity

protein serine kinase activity

phosphotransferase activity, alcohol group as acceptor [inference]

protein kinase activity [inference]

protein serine/threonine kinase activity [inference]

MAP kinase kinase kinase activity

JUN kinase kinase kinase activity

protein serine kinase activity

catalytic activity, acting on a protein [inference]

protein kinase activity [inference]

protein serine/threonine kinase activity [inference]

MAP kinase kinase kinase activity

JUN kinase kinase kinase activity

protein serine kinase activity

binding [inference]

protein binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

cation binding [inference]

metal ion binding [inference]

magnesium ion binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

Gene Ontology information from NCBI Gene and UniProt.

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GlyCosmos Portal v4.5.0

Last updated: April 6, 2026