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leucine rich repeat and sterile alpha motif containing 1

Summary

Gene Symbol

LRSAM1

Organism

Homo sapiens (human)

External Links

NCBI Gene

90678

PubChem

90678

Alliance of Genome Resources

HGNC:25135

JoGo

LRSAM1

TogoVar

LRSAM1

Annotation

Keyword

Alternative splicing
Autophagy
Charcot-Marie-Tooth disease
Coiled coil
Cytoplasm
Disease variant
Leucine-rich repeat
Neurodegeneration
Phosphoprotein
Protein transport
Proteomics identification
Reference proteome
Repeat
Transferase
Ubl conjugation
Ubl conjugation pathway
Zinc-finger

Proteins

Displaying **all 2** entries
UniProt	Protein Name
A0A6Q8PGW1	Leucine-rich repeat and sterile alpha motif-containing protein 1 RING-type E3 ubiquitin transferase LRSAM1 Tsg101-associated ligase
Q6UWE0	Leucine-rich repeat and sterile alpha motif-containing protein 1 RING-type E3 ubiquitin transferase LRSAM1 Tsg101-associated ligase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 9 in total

1

2

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GO Term	Evidence Code	PMID
protein polyubiquitination	IDA	18077552
autophagy	IEA
protein catabolic process	IMP	18077552
negative regulation of endocytosis	IMP	15256501
viral budding	IMP	15256501

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein catabolic process

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein ubiquitination [inference]

organonitrogen compound catabolic process [inference]

protein catabolic process

catabolic process [inference]

cellular catabolic process [inference]

autophagy

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process

organonitrogen compound catabolic process [inference]

protein catabolic process

cellular metabolic process [inference]

cellular catabolic process [inference]

autophagy

primary metabolic process [inference]

protein metabolic process [inference]

protein catabolic process

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein ubiquitination [inference]

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process

protein metabolic process [inference]

protein catabolic process

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein ubiquitination [inference]

macromolecule modification [inference]

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein ubiquitination [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein catabolic process

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein ubiquitination [inference]

organonitrogen compound catabolic process [inference]

protein catabolic process

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process

organonitrogen compound catabolic process [inference]

protein catabolic process

cellular process [inference]

vesicle-mediated transport [inference]

endocytosis [inference]

ubiquitin-dependent endocytosis

cellular metabolic process [inference]

cellular catabolic process [inference]

autophagy

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

establishment of protein localization to organelle [inference]

ubiquitin-dependent endocytosis

establishment of protein localization [inference]

protein transport [inference]

ubiquitin-dependent endocytosis

establishment of protein localization to organelle [inference]

ubiquitin-dependent endocytosis

process utilizing autophagic mechanism [inference]

autophagy

viral process [inference]

viral budding

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

establishment of protein localization to organelle [inference]

ubiquitin-dependent endocytosis

establishment of protein localization [inference]

protein transport [inference]

ubiquitin-dependent endocytosis

establishment of protein localization to organelle [inference]

ubiquitin-dependent endocytosis

establishment of localization [inference]

transport [inference]

vesicle-mediated transport [inference]

endocytosis [inference]

ubiquitin-dependent endocytosis

organic substance transport [inference]

protein transport [inference]

ubiquitin-dependent endocytosis

nitrogen compound transport [inference]

protein transport [inference]

ubiquitin-dependent endocytosis

import into cell [inference]

endocytosis [inference]

ubiquitin-dependent endocytosis

establishment of protein localization [inference]

protein transport [inference]

ubiquitin-dependent endocytosis

establishment of protein localization to organelle [inference]

ubiquitin-dependent endocytosis

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

establishment of protein localization to organelle [inference]

ubiquitin-dependent endocytosis

establishment of protein localization [inference]

protein transport [inference]

ubiquitin-dependent endocytosis

establishment of protein localization to organelle [inference]

ubiquitin-dependent endocytosis

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

positive regulation of metabolic process [inference]

positive regulation of catabolic process [inference]

positive regulation of cellular catabolic process [inference]

positive regulation of autophagy [inference]

positive regulation of macroautophagy [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular catabolic process [inference]

positive regulation of autophagy [inference]

positive regulation of macroautophagy [inference]

regulation of catabolic process [inference]

positive regulation of catabolic process [inference]

positive regulation of cellular catabolic process [inference]

positive regulation of autophagy [inference]

positive regulation of macroautophagy [inference]

regulation of cellular catabolic process [inference]

regulation of autophagy [inference]

positive regulation of autophagy [inference]

positive regulation of macroautophagy [inference]

regulation of macroautophagy [inference]

positive regulation of macroautophagy [inference]

regulation of xenophagy [inference]

positive regulation of xenophagy

positive regulation of cellular catabolic process [inference]

positive regulation of autophagy [inference]

positive regulation of macroautophagy [inference]

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular catabolic process [inference]

positive regulation of autophagy [inference]

positive regulation of macroautophagy [inference]

regulation of cellular catabolic process [inference]

regulation of autophagy [inference]

positive regulation of autophagy [inference]

positive regulation of macroautophagy [inference]

regulation of macroautophagy [inference]

positive regulation of macroautophagy [inference]

regulation of xenophagy [inference]

positive regulation of xenophagy

positive regulation of cellular catabolic process [inference]

positive regulation of autophagy [inference]

positive regulation of macroautophagy [inference]

regulation of localization [inference]

regulation of transport [inference]

negative regulation of transport [inference]

negative regulation of endocytosis

regulation of vesicle-mediated transport [inference]

regulation of endocytosis [inference]

negative regulation of endocytosis

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of catabolic process [inference]

positive regulation of cellular catabolic process [inference]

positive regulation of autophagy [inference]

positive regulation of macroautophagy [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular catabolic process [inference]

positive regulation of autophagy [inference]

positive regulation of macroautophagy [inference]

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular catabolic process [inference]

positive regulation of autophagy [inference]

positive regulation of macroautophagy [inference]

positive regulation of cellular component biogenesis [inference]

positive regulation of organelle assembly [inference]

positive regulation of autophagosome assembly

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of vacuole organization [inference]

positive regulation of autophagosome assembly

positive regulation of organelle assembly [inference]

positive regulation of autophagosome assembly

positive regulation of response to stimulus [inference]

positive regulation of defense response [inference]

positive regulation of xenophagy

positive regulation of response to external stimulus [inference]

positive regulation of xenophagy

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of cellular component organization [inference]

negative regulation of endocytosis

negative regulation of transport [inference]

negative regulation of endocytosis

regulation of response to stimulus [inference]

regulation of response to biotic stimulus [inference]

regulation of xenophagy [inference]

positive regulation of xenophagy

regulation of response to external stimulus [inference]

positive regulation of response to external stimulus [inference]

positive regulation of xenophagy

regulation of xenophagy [inference]

positive regulation of xenophagy

positive regulation of response to stimulus [inference]

positive regulation of defense response [inference]

positive regulation of xenophagy

positive regulation of response to external stimulus [inference]

positive regulation of xenophagy

regulation of response to stress [inference]

regulation of defense response [inference]

positive regulation of defense response [inference]

positive regulation of xenophagy

regulation of cellular process [inference]

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular catabolic process [inference]

positive regulation of autophagy [inference]

positive regulation of macroautophagy [inference]

regulation of cellular catabolic process [inference]

regulation of autophagy [inference]

positive regulation of autophagy [inference]

positive regulation of macroautophagy [inference]

regulation of macroautophagy [inference]

positive regulation of macroautophagy [inference]

regulation of xenophagy [inference]

positive regulation of xenophagy

positive regulation of cellular catabolic process [inference]

positive regulation of autophagy [inference]

positive regulation of macroautophagy [inference]

regulation of cellular component biogenesis [inference]

positive regulation of cellular component biogenesis [inference]

positive regulation of organelle assembly [inference]

positive regulation of autophagosome assembly

regulation of organelle assembly [inference]

positive regulation of organelle assembly [inference]

positive regulation of autophagosome assembly

regulation of autophagosome assembly [inference]

positive regulation of autophagosome assembly

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular catabolic process [inference]

positive regulation of autophagy [inference]

positive regulation of macroautophagy [inference]

positive regulation of cellular component biogenesis [inference]

positive regulation of organelle assembly [inference]

positive regulation of autophagosome assembly

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of vacuole organization [inference]

positive regulation of autophagosome assembly

positive regulation of organelle assembly [inference]

positive regulation of autophagosome assembly

negative regulation of cellular process [inference]

negative regulation of cellular component organization [inference]

negative regulation of endocytosis

regulation of cellular component organization [inference]

regulation of endocytosis [inference]

negative regulation of endocytosis

regulation of organelle organization [inference]

positive regulation of organelle organization [inference]

positive regulation of vacuole organization [inference]

positive regulation of autophagosome assembly

positive regulation of organelle assembly [inference]

positive regulation of autophagosome assembly

regulation of vacuole organization [inference]

positive regulation of vacuole organization [inference]

positive regulation of autophagosome assembly

regulation of autophagosome assembly [inference]

positive regulation of autophagosome assembly

regulation of organelle assembly [inference]

positive regulation of organelle assembly [inference]

positive regulation of autophagosome assembly

regulation of autophagosome assembly [inference]

positive regulation of autophagosome assembly

negative regulation of cellular component organization [inference]

negative regulation of endocytosis

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of vacuole organization [inference]

positive regulation of autophagosome assembly

positive regulation of organelle assembly [inference]

positive regulation of autophagosome assembly

regulation of vesicle-mediated transport [inference]

regulation of endocytosis [inference]

negative regulation of endocytosis

Displaying **all 3** entries
GO Term	Evidence Code	PMID
cytoplasm	IDA	15256501 18077552
cytosol	IDA
membrane	IDA	15256501

GO Hierarchy

cellular component

cellular anatomical entity [inference]

Displaying **all 5** entries
GO Term	Evidence Code	PMID
ubiquitin-protein transferase activity	IDA	15256501 18077552
protein binding	IPI	15256501 16189514 16713569 18077552 19549727 19690564 21044950 23245322 25260751 25416956 25484098 27615052 32296183 32814053 33961781
zinc ion binding	IEA
metal ion binding
ubiquitin protein ligase activity	IDA	23245322