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ubiquitin specific peptidase 14

Summary

Gene Symbol

USP14

Organism

Homo sapiens (human)

External Links

NCBI Gene

9097

PubChem

9097

Alliance of Genome Resources

HGNC:12612

JoGo

USP14

TogoVar

USP14

Annotation

Keyword

3D-structure
Acetylation
Alternative splicing
Cell membrane
Cytoplasm
Innate immunity
Phosphoprotein
Proteasome
Proteomics identification
Reference proteome
Thiol protease
Ubl conjugation pathway

Proteins

Displaying 1 entry
UniProt	Protein Name
P54578	Deubiquitinating enzyme 14 Ubiquitin thioesterase 14 Ubiquitin-specific-processing protease 14

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
chemical synaptic transmission	IEA
proteasome-mediated ubiquitin-dependent protein catabolic process	IEA
innate immune response	IEA
regulation of chemotaxis	IMP	19106094
regulation of proteasomal protein catabolic process	IMP	18162577

GO Hierarchy

biological process

immune system process [inference]

immune response [inference]

innate immune response

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein removal [inference]

protein deubiquitination [inference]

protein K48-linked deubiquitination

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

catabolic process [inference]

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

modification-dependent macromolecule catabolic process [inference]

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein removal [inference]

protein deubiquitination [inference]

protein K48-linked deubiquitination

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

modification-dependent macromolecule catabolic process [inference]

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein removal [inference]

protein deubiquitination [inference]

protein K48-linked deubiquitination

macromolecule modification [inference]

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein removal [inference]

protein deubiquitination [inference]

protein K48-linked deubiquitination

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein removal [inference]

protein deubiquitination [inference]

protein K48-linked deubiquitination

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

modification-dependent macromolecule catabolic process [inference]

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

cellular process [inference]

cell communication [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

defense response to other organism [inference]

innate immune response

response to stimulus [inference]

response to stress [inference]

defense response [inference]

defense response to other organism [inference]

innate immune response

immune response [inference]

innate immune response

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

defense response to other organism [inference]

innate immune response

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

defense response to other organism [inference]

innate immune response

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

negative regulation of metabolic process [inference]

negative regulation of catabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of proteasomal protein catabolic process [inference]

negative regulation of ERAD pathway

negative regulation of ubiquitin-dependent protein catabolic process

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of proteasomal protein catabolic process [inference]

negative regulation of ERAD pathway

negative regulation of proteolysis [inference]

negative regulation of proteolysis involved in protein catabolic process [inference]

negative regulation of proteasomal protein catabolic process [inference]

negative regulation of ERAD pathway

negative regulation of ubiquitin-dependent protein catabolic process

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of proteasomal protein catabolic process [inference]

negative regulation of ERAD pathway

negative regulation of proteolysis [inference]

negative regulation of proteolysis involved in protein catabolic process [inference]

negative regulation of proteasomal protein catabolic process [inference]

negative regulation of ERAD pathway

negative regulation of ubiquitin-dependent protein catabolic process

regulation of catabolic process [inference]

negative regulation of catabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of proteasomal protein catabolic process [inference]

negative regulation of ERAD pathway

negative regulation of ubiquitin-dependent protein catabolic process

regulation of protein catabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of proteasomal protein catabolic process [inference]

negative regulation of ERAD pathway

regulation of proteasomal protein catabolic process

negative regulation of proteasomal protein catabolic process [inference]

negative regulation of ERAD pathway

regulation of ERAD pathway [inference]

negative regulation of ERAD pathway

regulation of ubiquitin-dependent protein catabolic process [inference]

negative regulation of ubiquitin-dependent protein catabolic process

regulation of nitrogen compound metabolic process [inference]

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of proteasomal protein catabolic process [inference]

negative regulation of ERAD pathway

negative regulation of proteolysis [inference]

negative regulation of proteolysis involved in protein catabolic process [inference]

negative regulation of proteasomal protein catabolic process [inference]

negative regulation of ERAD pathway

negative regulation of ubiquitin-dependent protein catabolic process

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

negative regulation of proteolysis [inference]

negative regulation of proteolysis involved in protein catabolic process [inference]

negative regulation of proteasomal protein catabolic process [inference]

negative regulation of ERAD pathway

negative regulation of ubiquitin-dependent protein catabolic process

regulation of proteolysis involved in protein catabolic process [inference]

regulation of proteasomal protein catabolic process

negative regulation of proteasomal protein catabolic process [inference]

negative regulation of ERAD pathway

regulation of ERAD pathway [inference]

negative regulation of ERAD pathway

negative regulation of proteolysis involved in protein catabolic process [inference]

negative regulation of proteasomal protein catabolic process [inference]

negative regulation of ERAD pathway

negative regulation of ubiquitin-dependent protein catabolic process

regulation of ubiquitin-dependent protein catabolic process [inference]

negative regulation of ubiquitin-dependent protein catabolic process

regulation of protein catabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of proteasomal protein catabolic process [inference]

negative regulation of ERAD pathway

regulation of proteasomal protein catabolic process

negative regulation of proteasomal protein catabolic process [inference]

negative regulation of ERAD pathway

regulation of ERAD pathway [inference]

negative regulation of ERAD pathway

negative regulation of protein metabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of proteasomal protein catabolic process [inference]

negative regulation of ERAD pathway

negative regulation of proteolysis [inference]

negative regulation of proteolysis involved in protein catabolic process [inference]

negative regulation of proteasomal protein catabolic process [inference]

negative regulation of ERAD pathway

negative regulation of ubiquitin-dependent protein catabolic process

regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of proteasomal protein catabolic process [inference]

negative regulation of ERAD pathway

negative regulation of proteolysis [inference]

negative regulation of proteolysis involved in protein catabolic process [inference]

negative regulation of proteasomal protein catabolic process [inference]

negative regulation of ERAD pathway

negative regulation of ubiquitin-dependent protein catabolic process

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

negative regulation of proteolysis [inference]

negative regulation of proteolysis involved in protein catabolic process [inference]

negative regulation of proteasomal protein catabolic process [inference]

negative regulation of ERAD pathway

negative regulation of ubiquitin-dependent protein catabolic process

regulation of proteolysis involved in protein catabolic process [inference]

regulation of proteasomal protein catabolic process

negative regulation of proteasomal protein catabolic process [inference]

negative regulation of ERAD pathway

regulation of ERAD pathway [inference]

negative regulation of ERAD pathway

negative regulation of proteolysis involved in protein catabolic process [inference]

negative regulation of proteasomal protein catabolic process [inference]

negative regulation of ERAD pathway

negative regulation of ubiquitin-dependent protein catabolic process

regulation of ubiquitin-dependent protein catabolic process [inference]

negative regulation of ubiquitin-dependent protein catabolic process

regulation of protein catabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of proteasomal protein catabolic process [inference]

negative regulation of ERAD pathway

regulation of proteasomal protein catabolic process

negative regulation of proteasomal protein catabolic process [inference]

negative regulation of ERAD pathway

regulation of ERAD pathway [inference]

negative regulation of ERAD pathway

negative regulation of protein metabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of proteasomal protein catabolic process [inference]

negative regulation of ERAD pathway

negative regulation of proteolysis [inference]

negative regulation of proteolysis involved in protein catabolic process [inference]

negative regulation of proteasomal protein catabolic process [inference]

negative regulation of ERAD pathway

negative regulation of ubiquitin-dependent protein catabolic process

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

negative regulation of proteolysis [inference]

negative regulation of proteolysis involved in protein catabolic process [inference]

negative regulation of proteasomal protein catabolic process [inference]

negative regulation of ERAD pathway

negative regulation of ubiquitin-dependent protein catabolic process

regulation of proteolysis involved in protein catabolic process [inference]

regulation of proteasomal protein catabolic process

negative regulation of proteasomal protein catabolic process [inference]

negative regulation of ERAD pathway

regulation of ERAD pathway [inference]

negative regulation of ERAD pathway

negative regulation of proteolysis involved in protein catabolic process [inference]

negative regulation of proteasomal protein catabolic process [inference]

negative regulation of ERAD pathway

negative regulation of ubiquitin-dependent protein catabolic process

regulation of ubiquitin-dependent protein catabolic process [inference]

negative regulation of ubiquitin-dependent protein catabolic process

regulation of protein catabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of proteasomal protein catabolic process [inference]

negative regulation of ERAD pathway

regulation of proteasomal protein catabolic process

negative regulation of proteasomal protein catabolic process [inference]

negative regulation of ERAD pathway

regulation of ERAD pathway [inference]

negative regulation of ERAD pathway

negative regulation of protein metabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of proteasomal protein catabolic process [inference]

negative regulation of ERAD pathway

negative regulation of proteolysis [inference]

negative regulation of proteolysis involved in protein catabolic process [inference]

negative regulation of proteasomal protein catabolic process [inference]

negative regulation of ERAD pathway

negative regulation of ubiquitin-dependent protein catabolic process

signaling [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission

regulation of locomotion [inference]

regulation of chemotaxis

negative regulation of biological process [inference]

negative regulation of metabolic process [inference]

negative regulation of catabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of proteasomal protein catabolic process [inference]

negative regulation of ERAD pathway

negative regulation of ubiquitin-dependent protein catabolic process

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of proteasomal protein catabolic process [inference]

negative regulation of ERAD pathway

negative regulation of proteolysis [inference]

negative regulation of proteolysis involved in protein catabolic process [inference]

negative regulation of proteasomal protein catabolic process [inference]

negative regulation of ERAD pathway

negative regulation of ubiquitin-dependent protein catabolic process

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of proteasomal protein catabolic process [inference]

negative regulation of ERAD pathway

negative regulation of proteolysis [inference]

negative regulation of proteolysis involved in protein catabolic process [inference]

negative regulation of proteasomal protein catabolic process [inference]

negative regulation of ERAD pathway

negative regulation of ubiquitin-dependent protein catabolic process

negative regulation of cellular process [inference]

negative regulation of response to endoplasmic reticulum stress [inference]

negative regulation of ERAD pathway

negative regulation of response to stimulus [inference]

negative regulation of response to endoplasmic reticulum stress [inference]

negative regulation of ERAD pathway

regulation of response to stimulus [inference]

regulation of response to external stimulus [inference]

regulation of chemotaxis

negative regulation of response to stimulus [inference]

negative regulation of response to endoplasmic reticulum stress [inference]

negative regulation of ERAD pathway

regulation of response to stress [inference]

regulation of cellular response to stress [inference]

regulation of response to endoplasmic reticulum stress [inference]

negative regulation of response to endoplasmic reticulum stress [inference]

negative regulation of ERAD pathway

regulation of ERAD pathway [inference]

negative regulation of ERAD pathway

regulation of cellular process [inference]

negative regulation of cellular process [inference]

negative regulation of response to endoplasmic reticulum stress [inference]

negative regulation of ERAD pathway

regulation of cellular response to stress [inference]

regulation of response to endoplasmic reticulum stress [inference]

negative regulation of response to endoplasmic reticulum stress [inference]

negative regulation of ERAD pathway

regulation of ERAD pathway [inference]

negative regulation of ERAD pathway

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
proteasome complex	IEA
nucleolus	IDA
cytoplasm	IDA	27666593
endoplasmic reticulum	IDA
cytosol	TAS

GO Hierarchy

cellular component

protein-containing complex [inference]

intracellular protein-containing complex [inference]

proteasome complex

catalytic complex [inference]

peptidase complex [inference]

endopeptidase complex [inference]

proteasome complex

cellular anatomical entity [inference]

cytoplasm

cytosol

cytosolic region [inference]

presynaptic cytosol

cell surface

membrane [inference]

plasma membrane

cell junction [inference]

synapse [inference]

glutamatergic synapse

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular vesicle [inference]

cytoplasmic vesicle

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

nucleolus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular vesicle [inference]

cytoplasmic vesicle

intracellular non-membrane-bounded organelle [inference]

nucleolus

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
cysteine-type endopeptidase activity	TAS	9827704
cysteine-type deubiquitinase activity	IDA	19106094 23958854
cysteine-type deubiquitinase activity	IBA
endopeptidase inhibitor activity	IMP	18162577
protein binding	IPI	19106094 19135427

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity [inference]

endopeptidase activity [inference]

cysteine-type endopeptidase activity

cysteine-type peptidase activity [inference]

ubiquitin-like protein peptidase activity [inference]

deubiquitinase activity

catalytic activity, acting on a protein [inference]

peptidase activity [inference]

endopeptidase activity [inference]

cysteine-type endopeptidase activity

cysteine-type peptidase activity [inference]

ubiquitin-like protein peptidase activity [inference]

deubiquitinase activity

binding [inference]

protein binding

protein-containing complex binding [inference]

proteasome binding

molecular function regulator activity [inference]

enzyme regulator activity [inference]

enzyme inhibitor activity [inference]

peptidase inhibitor activity [inference]

endopeptidase inhibitor activity

peptidase regulator activity [inference]

peptidase inhibitor activity [inference]

endopeptidase inhibitor activity

endopeptidase regulator activity [inference]

endopeptidase inhibitor activity

molecular function inhibitor activity [inference]

enzyme inhibitor activity [inference]

peptidase inhibitor activity [inference]

endopeptidase inhibitor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

UBIQUITIN CARBOXYL-TERMINAL HYDROLASE

Functional Category

D: Cell cycle control, cell division, chromosome partitioning
E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones

Displaying **all 5** entries
Gene Ontology
hydrolase activity
proteasome binding
proteasome-mediated ubiquitin-dependent protein catabolic process
proteolysis
regulation of proteasomal protein catabolic process

Displaying **all 7** entries
InterPro
Papain-like cysteine peptidase superfamily
Peptidase C19, ubiquitin carboxyl-terminal hydrolase
Ubiquitin carboxyl-terminal hydrolase 14-like
Ubiquitin specific protease domain
Ubiquitin specific protease, conserved site
Ubiquitin-like domain superfamily
Ubiquitin-like domain

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Guidelines

Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements