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ceramide synthase 5

Summary

Gene Symbol

CERS5

Aliases

FLJ25304
MGC45411
Trh4

Organism

Homo sapiens (human)

External Links

NCBI Gene

91012

HGNC

23749

KEGG Gene ID

hsa:91012

PubChem

91012

Alliance of Genome Resources

HGNC:23749

Annotation

Keyword

Alternative splicing
Endoplasmic reticulum
Glycoprotein
Lipid biosynthesis
Phosphoprotein
Reference proteome
Sphingolipid metabolism
Transferase
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q8N5B7	LAG1 longevity assurance homolog 5 Sphingoid base N-palmitoyltransferase CERS5 Sphingosine N-acyltransferase CERS5

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 3** entries
GO Term	Evidence Code	PMID
ceramide biosynthetic process	IBA IDA	16951403 29632068
oligodendrocyte development	IEA
sphingolipid biosynthetic process

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

ceramide biosynthetic process

amide metabolic process [inference]

ceramide metabolic process [inference]

ceramide biosynthetic process

amide biosynthetic process [inference]

ceramide biosynthetic process

organonitrogen compound metabolic process [inference]

sphingolipid metabolic process [inference]

ceramide metabolic process [inference]

ceramide biosynthetic process

sphingolipid biosynthetic process

ceramide biosynthetic process

organonitrogen compound biosynthetic process [inference]

sphingolipid biosynthetic process

ceramide biosynthetic process

biosynthetic process [inference]

cellular biosynthetic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

ceramide biosynthetic process

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process

ceramide biosynthetic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process

ceramide biosynthetic process

organonitrogen compound biosynthetic process [inference]

sphingolipid biosynthetic process

ceramide biosynthetic process

cellular metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

ceramide biosynthetic process

cellular biosynthetic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

ceramide biosynthetic process

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process

ceramide biosynthetic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

sphingolipid metabolic process [inference]

ceramide metabolic process [inference]

ceramide biosynthetic process

sphingolipid biosynthetic process

ceramide biosynthetic process

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process

ceramide biosynthetic process

primary metabolic process [inference]

lipid metabolic process [inference]

lipid biosynthetic process [inference]

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process

ceramide biosynthetic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

sphingolipid metabolic process [inference]

ceramide metabolic process [inference]

ceramide biosynthetic process

sphingolipid biosynthetic process

ceramide biosynthetic process

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process

ceramide biosynthetic process

organic substance metabolic process [inference]

lipid metabolic process [inference]

lipid biosynthetic process [inference]

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process

ceramide biosynthetic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

sphingolipid metabolic process [inference]

ceramide metabolic process [inference]

ceramide biosynthetic process

sphingolipid biosynthetic process

ceramide biosynthetic process

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process

ceramide biosynthetic process

organonitrogen compound metabolic process [inference]

sphingolipid metabolic process [inference]

ceramide metabolic process [inference]

ceramide biosynthetic process

sphingolipid biosynthetic process

ceramide biosynthetic process

organonitrogen compound biosynthetic process [inference]

sphingolipid biosynthetic process

ceramide biosynthetic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process

ceramide biosynthetic process

organonitrogen compound biosynthetic process [inference]

sphingolipid biosynthetic process

ceramide biosynthetic process

cellular process [inference]

cellular metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

ceramide biosynthetic process

cellular biosynthetic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

ceramide biosynthetic process

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process

ceramide biosynthetic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

sphingolipid metabolic process [inference]

ceramide metabolic process [inference]

ceramide biosynthetic process

sphingolipid biosynthetic process

ceramide biosynthetic process

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process

ceramide biosynthetic process

cellular developmental process [inference]

cell development [inference]

glial cell development [inference]

oligodendrocyte development

developmental process [inference]

anatomical structure development [inference]

cell development [inference]

glial cell development [inference]

oligodendrocyte development

cellular developmental process [inference]

cell development [inference]

glial cell development [inference]

oligodendrocyte development

Displaying 1 entry
GO Term	Evidence Code	PMID
endoplasmic reticulum membrane

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

organelle membrane [inference]

endoplasmic reticulum membrane

Displaying **all 2** entries
GO Term	Evidence Code	PMID
DNA binding	IEA
sphingosine N-acyltransferase activity	IBA IDA TAS	16951403 29632068

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

acyltransferase activity [inference]

acyltransferase activity, transferring groups other than amino-acyl groups [inference]

N-acyltransferase activity [inference]

sphingosine N-acyltransferase activity

binding [inference]

organic cyclic compound binding [inference]

nucleic acid binding [inference]

DNA binding

Gene Ontology information from NCBI Gene and UniProt.

Human Protein Atlas

ENSG00000139624

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

KEGG BRITE Database

Orthology

K23727

Name

sphingoid base N-palmitoyltransferase [EC:2.3.1.291]

References

15823095

Rhea

sphing-4-enine + a fatty acyl-CoA

H⁺ + an N-acylsphing-4-enine + CoA

Enzyme

2.3.1.24

PMID

hexadecanoyl-CoA + a sphingoid base

an N-hexadecanoyl-sphingoid base + H⁺ + CoA

Enzyme

2.3.1.291

PMID

Disease

Disease Ontology

Displaying entries **1 - 10** of 12 in total

1

2

Next ›

Last »
DO ID	Disease Name	Source
DOID:10763	hypertension	DisGeNET
DOID:10825	essential hypertension	DisGeNET
DOID:162	cancer	DisGeNET DisGeNET
DOID:1984	rectal benign neoplasm	DisGeNET
DOID:1993	rectum cancer	DisGeNET
DOID:1996	rectum adenocarcinoma	DisGeNET
DOID:219	colon cancer	DisGeNET
DOID:235	colonic benign neoplasm	DisGeNET
DOID:4766	embryoma	DisGeNET
DOID:5672	large intestine cancer	DisGeNET

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP001261
Gene Name: ceramide synthase 5

Ortholog

Displaying entries **1 - 10** of 62 in total

1

2

3

4

5

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Next ›

Last »
Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Caenorhabditis elegans	177660	WB:WBGene00002043
Drosophila melanogaster	50392	FB:FBgn0040918
Ciona intestinalis	778663		CIOIN01348
Danio rerio	323020	ZFIN:ZDB-GENE-030131-1740	DANRE23377
Ictalurus punctatus	108255109		ICTPU16668
Salmo trutta	115150046		SALTR32494
Salmo trutta	115207294		SALTR36428
Gadus morhua	115557500		GADMO09726
Oryzias latipes	101175231		ORYLA14011
Oreochromis niloticus	100695512		ORENI58401

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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GlyCosmos Portal v4.0.0

Last updated: August 19, 2024