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pre-mRNA splicing tri-snRNP complex factor PRPF4

Summary

Gene Symbol

PRPF4

Organism

Homo sapiens (human)

External Links

NCBI Gene

9128

PubChem

9128

Alliance of Genome Resources

HGNC:17349

Annotation

Keyword

3D-structure
Acetylation
Alternative splicing
Direct protein sequencing
Disease variant
Nucleus
Reference proteome
Repeat
Retinitis pigmentosa
Spliceosome
WD repeat

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q5T1M7
O43172	PRP4 homolog U4/U6 snRNP 60 kDa protein WD splicing factor Prp4

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
RNA splicing, via transesterification reactions	NAS	9328476
mRNA splicing, via spliceosome	NAS	30975767
mRNA splicing, via spliceosome	IC	9570313
mRNA splicing, via spliceosome	IDA	28781166
mRNA splicing, via spliceosome	IBA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing

mRNA processing [inference]

mRNA splicing, via spliceosome

RNA splicing

RNA splicing, via transesterification reactions

RNA splicing, via transesterification reactions with bulged adenosine as nucleophile [inference]

mRNA splicing, via spliceosome

mRNA metabolic process [inference]

mRNA processing [inference]

mRNA splicing, via spliceosome

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing

mRNA processing [inference]

mRNA splicing, via spliceosome

RNA splicing

RNA splicing, via transesterification reactions

RNA splicing, via transesterification reactions with bulged adenosine as nucleophile [inference]

mRNA splicing, via spliceosome

mRNA metabolic process [inference]

mRNA processing [inference]

mRNA splicing, via spliceosome

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing

mRNA processing [inference]

mRNA splicing, via spliceosome

RNA splicing

RNA splicing, via transesterification reactions

RNA splicing, via transesterification reactions with bulged adenosine as nucleophile [inference]

mRNA splicing, via spliceosome

mRNA metabolic process [inference]

mRNA processing [inference]

mRNA splicing, via spliceosome

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing

mRNA processing [inference]

mRNA splicing, via spliceosome

RNA splicing

RNA splicing, via transesterification reactions

RNA splicing, via transesterification reactions with bulged adenosine as nucleophile [inference]

mRNA splicing, via spliceosome

mRNA metabolic process [inference]

mRNA processing [inference]

mRNA splicing, via spliceosome

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing

mRNA processing [inference]

mRNA splicing, via spliceosome

RNA splicing

RNA splicing, via transesterification reactions

RNA splicing, via transesterification reactions with bulged adenosine as nucleophile [inference]

mRNA splicing, via spliceosome

mRNA metabolic process [inference]

mRNA processing [inference]

mRNA splicing, via spliceosome

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing

mRNA processing [inference]

mRNA splicing, via spliceosome

RNA splicing

RNA splicing, via transesterification reactions

RNA splicing, via transesterification reactions with bulged adenosine as nucleophile [inference]

mRNA splicing, via spliceosome

mRNA metabolic process [inference]

mRNA processing [inference]

mRNA splicing, via spliceosome

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing

mRNA processing [inference]

mRNA splicing, via spliceosome

RNA splicing

RNA splicing, via transesterification reactions

RNA splicing, via transesterification reactions with bulged adenosine as nucleophile [inference]

mRNA splicing, via spliceosome

mRNA metabolic process [inference]

mRNA processing [inference]

mRNA splicing, via spliceosome

cellular process [inference]

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing

mRNA processing [inference]

mRNA splicing, via spliceosome

RNA splicing

RNA splicing, via transesterification reactions

RNA splicing, via transesterification reactions with bulged adenosine as nucleophile [inference]

mRNA splicing, via spliceosome

mRNA metabolic process [inference]

mRNA processing [inference]

mRNA splicing, via spliceosome

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing

mRNA processing [inference]

mRNA splicing, via spliceosome

RNA splicing

RNA splicing, via transesterification reactions

RNA splicing, via transesterification reactions with bulged adenosine as nucleophile [inference]

mRNA splicing, via spliceosome

mRNA metabolic process [inference]

mRNA processing [inference]

mRNA splicing, via spliceosome

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing

mRNA processing [inference]

mRNA splicing, via spliceosome

RNA splicing

RNA splicing, via transesterification reactions

RNA splicing, via transesterification reactions with bulged adenosine as nucleophile [inference]

mRNA splicing, via spliceosome

mRNA metabolic process [inference]

mRNA processing [inference]

mRNA splicing, via spliceosome

Displaying entries **1 - 5** of 13 in total

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GO Term	Evidence Code	PMID
nucleus	NAS	30975767
nucleus	IDA	28781166
nucleoplasm	TAS
spliceosomal complex	NAS	9328476
spliceosomal complex	IC	9570313

GO Hierarchy

cellular component

protein-containing complex [inference]

Sm-like protein family complex [inference]

small nuclear ribonucleoprotein complex [inference]

spliceosomal snRNP complex

U4/U6 snRNP

spliceosomal tri-snRNP complex [inference]

U4/U6 x U5 tri-snRNP complex

nuclear protein-containing complex [inference]

spliceosomal complex

U2-type spliceosomal complex [inference]

U2-type precatalytic spliceosome

precatalytic spliceosome [inference]

U2-type precatalytic spliceosome

small nuclear ribonucleoprotein complex [inference]

spliceosomal snRNP complex

U4/U6 snRNP

spliceosomal tri-snRNP complex [inference]

U4/U6 x U5 tri-snRNP complex

ribonucleoprotein complex [inference]

spliceosomal complex

U2-type spliceosomal complex [inference]

U2-type precatalytic spliceosome

precatalytic spliceosome [inference]

U2-type precatalytic spliceosome

small nuclear ribonucleoprotein complex [inference]

spliceosomal snRNP complex

U4/U6 snRNP

spliceosomal tri-snRNP complex [inference]

U4/U6 x U5 tri-snRNP complex

cellular anatomical entity [inference]

nucleoplasm

nuclear body [inference]

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

Displaying **all 3** entries
GO Term	Evidence Code	PMID
protein binding	IPI	16723661 19615732 22365833 23793891 25383878 26030138 28935721 29997244 33961781 9570313
U6 snRNA binding	IBA
U4 snRNA binding	IBA

GO Hierarchy

molecular function

binding [inference]

protein binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

RNA binding [inference]

snRNA binding [inference]

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

U4/U6 small nuclear ribonucleoprotein

Functional Category

E: Amino acid transport and metabolism
J: Translation, ribosomal structure and biogenesis
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
U4 snRNA binding
U6 snRNA binding

Displaying **all 7** entries
InterPro
G-protein beta WD-40 repeat
PRP4-like superfamily
Pre-mRNA processing factor 4 (PRP4)-like
WD40 repeat, conserved site
WD40 repeat
WD40-repeat-containing domain superfamily
WD40/YVTN repeat-like-containing domain superfamily

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0110392	retinitis pigmentosa 70	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 68 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	9128	Xenbase:XB-GENE-493298
Mus musculus	70052		MOUSE39867
Rattus norvegicus	298095		RATNO33839
Danio rerio	326944		DANRE35767
Pan troglodytes	464671		PANTR44631
Canis lupus familiaris	474807		CANLF02455
Bos taurus	508735		BOVIN35148
Macaca mulatta	705934		MACMU12426
Monodelphis domestica	100010266		MONDO06996
Monodelphis domestica	100011307		MONDO06996