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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
apoptosis inducing factor mitochondria associated 1
Summary
- Gene Symbol
-
- AIFM1
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Acetylation
- Alternative splicing
- Apoptosis
- Charcot-Marie-Tooth disease
- Cytoplasm
- DNA-binding
- Deafness
- Direct protein sequencing
- Disease variant
- Dwarfism
- FAD
- Intellectual disability
- Isopeptide bond
- Mitochondrion inner membrane
- NAD
- Neurodegeneration
- Nucleus
- Oxidoreductase
- Phosphoprotein
- Primary mitochondrial disease
- Proteomics identification
- Reference proteome
- Transit peptide
- Ubl conjugation
- Proteins
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| response to toxic substance | ||
| intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress | ||
| response to L-glutamate | ||
| response to ischemia | ||
| neuron differentiation |
GO Hierarchy
biological process
cellular process [inference]
response to stimulus [inference]
response to stress [inference]
response to chemical [inference]
cellular response to stimulus [inference]
localization [inference]
biological regulation [inference]
regulation of biological process [inference]
regulation of metabolic process [inference]
positive regulation of metabolic process [inference]
regulation of nitrogen compound metabolic process [inference]
regulation of macromolecule metabolic process [inference]
regulation of primary metabolic process [inference]
positive regulation of biological process [inference]
regulation of molecular function [inference]
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| protein binding | ||
| DNA binding | ||
| NADH dehydrogenase activity | ||
| FAD binding | ||
| poly-ADP-D-ribose binding |
GO Hierarchy
OrthoDB (Group)
- Group level
- Eukaryota
- Group Name
- Apoptosis-inducing factor
- Functional Category
-
- E: Amino acid transport and metabolism
- G: Carbohydrate transport and metabolism
- O: Posttranslational modification, protein turnover, chaperones
| Gene Ontology |
|---|
| flavin adenine dinucleotide binding |
| oxidoreductase activity |
| InterPro |
|---|
| FAD/NAD(P)-binding domain superfamily |
| FAD/NAD(P)-binding domain |
| FAD/NAD-linked reductase, dimerisation domain superfamily |
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0060536 | mitochondrial complex I deficiency | |
| DOID:0110212 | Charcot-Marie-Tooth disease X-linked recessive 4 | |
| DOID:0110429 | dilated cardiomyopathy 1H | |
| DOID:0111502 | combined oxidative phosphorylation deficiency 6 | |
| DOID:0111741 | X-linked deafness 5 | |
| DOID:10584 | retinitis pigmentosa | |
| DOID:10652 | Alzheimer's disease | |
| DOID:224 | transient cerebral ischemia | |
| DOID:3525 | middle cerebral artery infarction | |
| DOID:5327 | retinal detachment |
Ortholog
| Species | Gene ID | OrthoDB | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|---|
| 26926 | MGI:1349419 | MOUSE65244 | ||
| 33390 | FB:FBgn0031392 | |||
| 83533 | RGD:620817 | RATNO45050 | ||
| 176635 | WB:WBGene00006937 | |||
| 373125 | ZFIN:ZDB-GENE-030826-11 | |||
| 481048 | CANLF20149 | |||
| 535714 | BOVIN36295 | |||
| 549998 | Xenbase:XB-GENE-1016872 | |||
| 702773 | MACMU47373 | |||
| 768258 | FELCA39472 |
